(6 nodes) DNA topoisomerase, type IA, central network (Prevotella enoeca)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALO48180.1	DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
	AS203_03380	Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology. (687 aa)
	ALO48460.1	DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (685 aa)
	ALO48584.1	DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (694 aa)
	ALO48936.1	DNA topoisomerase III; Derived by automated computational analysis using gene prediction method: Protein Homology. (693 aa)
	topA	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (776 aa)