STRINGSTRING
LKI_01025 LKI_01025 LKI_01030 LKI_01030 LKI_01035 LKI_01035 LKI_01040 LKI_01040 LKI_01045 LKI_01045 folE folE LKI_01055 LKI_01055 LKI_01060 LKI_01060 LKI_01065 LKI_01065 fhs fhs LKI_02240 LKI_02240 LKI_05535 LKI_05535 thyA thyA folD folD LKI_08790 LKI_08790 LKI_09380 LKI_09380 LKI_09475 LKI_09475 glyA glyA LKI_09915 LKI_09915
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LKI_01025Acetyltransferase, GNAT family; COG0454 Histone acetyltransferase HPA2 and related acetyltransferases. (189 aa)
LKI_01030COG2183 Transcriptional accessory protein. (731 aa)
LKI_01035Dihydropteroate synthase; COG1216 Predicted glycosyltransferases. (351 aa)
LKI_01040COG0127 Xanthosine triphosphate pyrophosphatase. (199 aa)
LKI_01045COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (431 aa)
folECOG0302 GTP cyclohydrolase I. (191 aa)
LKI_01055GTP cyclohydrolase I; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (166 aa)
LKI_01060Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (127 aa)
LKI_01065Hypothetical protein; COG1115 Na+/alanine symporter. (241 aa)
fhsFormate--tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. (554 aa)
LKI_02240COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (295 aa)
LKI_05535FolC family protein; COG0285 Folylpolyglutamate synthase. (393 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (322 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (281 aa)
LKI_08790COG0207 Thymidylate synthase. (332 aa)
LKI_09380COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (443 aa)
LKI_09475Hypothetical protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa)
LKI_09915Hypothetical protein; COG0212 5-formyltetrahydrofolate cyclo-ligase. (327 aa)
Your Current Organism:
Leuconostoc kimchii
NCBI taxonomy Id: 762051
Other names: L. kimchii IMSNU 11154, Leuconostoc kimchii IMSNU 11154, Leuconostoc kimchii str. IMSNU 11154, Leuconostoc kimchii strain IMSNU 11154
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