STRINGSTRING
LKI_00440 LKI_00440 LKI_08160 LKI_08160 hisZ hisZ hisD hisD hisB hisB hisH hisH hisA hisA hisF hisF LKI_08195 LKI_08195 hisE hisE hisC hisC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LKI_00440Hypothetical protein; COG0241 Histidinol phosphatase and related phosphatases. (232 aa)
LKI_08160Histidinol-phosphatase; COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (285 aa)
hisZhistidine--tRNA ligase (putative); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (534 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (425 aa)
hisBCOG0131 Imidazoleglycerol-phosphate dehydratase. (195 aa)
hisHAmidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa)
hisACOG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (237 aa)
hisFCyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa)
LKI_08195phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (133 aa)
hisEHypothetical protein; COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. (108 aa)
hisCCOG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa)
Your Current Organism:
Leuconostoc kimchii
NCBI taxonomy Id: 762051
Other names: L. kimchii IMSNU 11154, Leuconostoc kimchii IMSNU 11154, Leuconostoc kimchii str. IMSNU 11154, Leuconostoc kimchii strain IMSNU 11154
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.