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LKI_07215 LKI_07215 LKI_07330 LKI_07330 LKI_07675 LKI_07675 LKI_07815 LKI_07815 LKI_07995 LKI_07995 LKI_08065 LKI_08065 LKI_08135 LKI_08135 LKI_08305 LKI_08305 hprK hprK LKI_08475 LKI_08475 LKI_08540 LKI_08540 LKI_08735 LKI_08735 ppnK ppnK LKI_08910 LKI_08910 LKI_09025 LKI_09025 LKI_09035 LKI_09035 LKI_09080 LKI_09080 LKI_09165 LKI_09165 cmk cmk LKI_09850 LKI_09850 LKI_09870 LKI_09870 LKI_09890 LKI_09890 thrB thrB ackA-2 ackA-2 LKI_09955 LKI_09955 argB argB LKI_06235 LKI_06235 LKI_06405 LKI_06405 pgk pgk adk adk ppk ppk tmk tmk LKI_06975 LKI_06975 LKI_07080 LKI_07080 tdk tdk galK galK LKI_00805 LKI_00805 LKI_01010 LKI_01010 LKI_01055 LKI_01055 pyrH pyrH LKI_01425 LKI_01425 LKI_01445 LKI_01445 rbsK rbsK LKI_01540 LKI_01540 LKI_01545 LKI_01545 LKI_02320 LKI_02320 LKI_02410 LKI_02410 LKI_02430 LKI_02430 LKI_02445 LKI_02445 LKI_02495 LKI_02495 LKI_02710 LKI_02710 udk udk LKI_02875 LKI_02875 LKI_03100 LKI_03100 LKI_03250 LKI_03250 rbsK-2 rbsK-2 LKI_03700 LKI_03700 LKI_03730 LKI_03730 LKI_03810 LKI_03810 LKI_03860 LKI_03860 LKI_04150 LKI_04150 LKI_04205 LKI_04205 LKI_04350 LKI_04350 prs prs LKI_04525 LKI_04525 LKI_04550 LKI_04550 LKI_04615 LKI_04615 LKI_04620 LKI_04620 LKI_04645 LKI_04645 LKI_04780 LKI_04780 LKI_04970 LKI_04970 ackA ackA thiM thiM LKI_05100 LKI_05100 proB proB coaE coaE LKI_05485 LKI_05485 LKI_05730 LKI_05730 gmk gmk
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LKI_07215Phosphoenolpyruvate--protein phosphatase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (571 aa)
LKI_07330PTS system, IIAB component, mannose/fructose/sorbose family; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (316 aa)
LKI_07675Transcription regulator; COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase. (303 aa)
LKI_07815Transcription regulator; COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase. (329 aa)
LKI_07995Hypothetical protein. (113 aa)
LKI_08065COG0105 Nucleoside diphosphate kinase. (137 aa)
LKI_08135COG1440 Phosphotransferase system cellobiose-specific component IIB. (104 aa)
LKI_08305COG0642 Signal transduction histidine kinase. (451 aa)
hprKBifunctional protein: HPr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisabl [...] (320 aa)
LKI_08475COG1428 Deoxynucleoside kinases. (210 aa)
LKI_08540COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (305 aa)
LKI_08735GTP pyrophosphokinase (putative); COG2357 Uncharacterized protein conserved in bacteria. (192 aa)
ppnKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (263 aa)
LKI_08910Glucokinase; COG1940 Transcriptional regulator/sugar kinase. (329 aa)
LKI_09025Sucrose PTS, EIIBCA; COG1264 Phosphotransferase system IIB components. (658 aa)
LKI_09035Fructokinase; COG1940 Transcriptional regulator/sugar kinase. (290 aa)
LKI_09080GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (749 aa)
LKI_09165Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (314 aa)
cmkCmk; COG0283 Cytidylate kinase. (225 aa)
LKI_09850COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
LKI_09870COG0818 Diacylglycerol kinase. (160 aa)
LKI_09890COG0527 Aspartokinases; Belongs to the aspartokinase family. (452 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (294 aa)
ackA-2Acetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (415 aa)
LKI_09955COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (164 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (270 aa)
LKI_06235Putative histidine kinase of the competence regulon, ComD; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (435 aa)
LKI_06405COG1072 Panthothenate kinase. (224 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (405 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (187 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (714 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa)
LKI_06975COG1428 Deoxynucleoside kinases. (213 aa)
LKI_07080Sensor protein kinase; COG0642 Signal transduction histidine kinase. (427 aa)
tdkCOG1435 Thymidine kinase. (201 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa)
LKI_00805Phosphoenolpyruvate-dependent sugar phosphotransferase system EIIB, probable sorbose specific; COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB. (156 aa)
LKI_01010COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (271 aa)
LKI_01055GTP cyclohydrolase I; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (166 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
LKI_01425COG1577 Mevalonate kinase. (310 aa)
LKI_01445Ribose-phosphate pyrophosphokinase; COG0462 Phosphoribosylpyrophosphate synthetase. (324 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (309 aa)
LKI_01540COG3407 Mevalonate pyrophosphate decarboxylase. (316 aa)
LKI_01545COG1577 Mevalonate kinase. (341 aa)
LKI_02320COG1440 Phosphotransferase system cellobiose-specific component IIB. (107 aa)
LKI_02410Hypothetical protein; COG1461 Predicted kinase related to dihydroxyacetone kinase. (565 aa)
LKI_02430Hypothetical protein; COG1564 Thiamine pyrophosphokinase. (214 aa)
LKI_02445COG0515 Serine/threonine protein kinase. (643 aa)
LKI_02495Transcription regulator; COG1056 Nicotinamide mononucleotide adenylyltransferase. (388 aa)
LKI_02710Gluconate kinase; COG1070 Sugar (pentulose and hexulose) kinases; Belongs to the FGGY kinase family. (512 aa)
udkCOG0572 Uridine kinase. (213 aa)
LKI_028752-dehydro-3-deoxygluconokinase; COG0524 Sugar kinases, ribokinase family. (320 aa)
LKI_03100Hypothetical protein; COG1983 Putative stress-responsive transcriptional regulator. (88 aa)
LKI_03250Hypothetical protein; COG1070 Sugar (pentulose and hexulose) kinases. (540 aa)
rbsK-2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (312 aa)
LKI_03700Histidine kinase; COG2244 Membrane protein involved in the export of O-antigen and teichoic acid. (437 aa)
LKI_03730Beta-glucosides PTS, EIIBCA; COG1264 Phosphotransferase system IIB components. (628 aa)
LKI_03810Sensor protein kinase; COG0642 Signal transduction histidine kinase. (292 aa)
LKI_03860Histidine protein kinase; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (275 aa)
LKI_04150COG1940 Transcriptional regulator/sugar kinase. (300 aa)
LKI_04205DNA topology modulation protein FLAR-related protein; COG0563 Adenylate kinase and related kinases. (160 aa)
LKI_04350COG4585 Signal transduction histidine kinase. (401 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
LKI_04525COG5002 Signal transduction histidine kinase. (619 aa)
LKI_04550COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (268 aa)
LKI_04615Beta-glucosides PTS, EIIABC; COG2190 Phosphotransferase system IIA components. (51 aa)
LKI_04620Beta-glucoside-specific PTS system IIABC component; COG2190 Phosphotransferase system IIA components. (634 aa)
LKI_04645COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism. (530 aa)
LKI_04780COG0194 Guanylate kinase. (193 aa)
LKI_04970COG0642 Signal transduction histidine kinase. (361 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (419 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (258 aa)
LKI_05100COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (277 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (271 aa)
coaEHypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa)
LKI_05485Fructokinase; COG1940 Transcriptional regulator/sugar kinase. (288 aa)
LKI_05730COG0642 Signal transduction histidine kinase. (368 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (198 aa)
Your Current Organism:
Leuconostoc kimchii
NCBI taxonomy Id: 762051
Other names: L. kimchii IMSNU 11154, Leuconostoc kimchii IMSNU 11154, Leuconostoc kimchii str. IMSNU 11154, Leuconostoc kimchii strain IMSNU 11154
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