STRINGSTRING
purM purM nadE nadE LKI_02955 LKI_02955 LKI_03690 LKI_03690 birA birA ddl ddl birA-2 birA-2 bioD bioD LKI_05300 LKI_05300 LKI_05305 LKI_05305 murF murF LKI_05535 LKI_05535 tmcAL tmcAL LKI_07175 LKI_07175 LKI_07180 LKI_07180 tilS tilS gatC gatC gatA gatA gatB gatB LKI_00355 LKI_00355 LKI_01045 LKI_01045 carB carB carA carA LKI_01320 LKI_01320 fhs fhs purD purD purL purL purQ purQ pyrG pyrG purA purA argG argG LKI_08835 LKI_08835 murC murC LKI_09005 LKI_09005 carA-2 carA-2 carB-2 carB-2 LKI_09380 LKI_09380 LKI_09395 LKI_09395 LKI_09915 LKI_09915 LKI_02545 LKI_02545 murD murD guaA guaA purK purK purC purC purS purS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purMCOG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (345 aa)
nadENAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (277 aa)
LKI_02955COG0095 Lipoate-protein ligase A. (336 aa)
LKI_03690Putative glutamate--cysteine ligase; COG2918 Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family. (480 aa)
birAbiotin--[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (326 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (377 aa)
birA-2biotin--[acetyl-CoA-carboxylase] ligase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (328 aa)
bioDDithiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (225 aa)
LKI_05300COG0439 Biotin carboxylase. (389 aa)
LKI_05305acetyl-CoA carboxylase beta subunit; COG0439 Biotin carboxylase. (55 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (443 aa)
LKI_05535FolC family protein; COG0285 Folylpolyglutamate synthase. (393 aa)
tmcALHypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (402 aa)
LKI_07175Cobyric acid synthase (putative); COG3442 Predicted glutamine amidotransferase. (243 aa)
LKI_07180COG0769 UDP-N-acetylmuramyl tripeptide synthase. (452 aa)
tilSCell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (435 aa)
gatCglutamyl-tRNA amidotransferase, subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (102 aa)
gatAglutamyl-tRNA amidotransferase, subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (488 aa)
gatBaspartyl/glutamyl-tRNA amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (487 aa)
LKI_00355COG0439 Biotin carboxylase. (446 aa)
LKI_01045COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (431 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1059 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (362 aa)
LKI_01320UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase; COG0769 UDP-N-acetylmuramyl tripeptide synthase; Belongs to the MurCDEF family. MurE subfamily. (491 aa)
fhsFormate--tetrahydrofolate ligase; COG2759 Formyltetrahydrofolate synthetase; Belongs to the formate--tetrahydrofolate ligase family. (554 aa)
purDCOG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (414 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (740 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
argGCOG0137 Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa)
LKI_08835Putative pre-B cell enhancing factor; COG1488 Nicotinic acid phosphoribosyltransferase; Belongs to the NAPRTase family. (467 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (444 aa)
LKI_09005COG0174 Glutamine synthetase. (448 aa)
carA-2COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (360 aa)
carB-2COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (837 aa)
LKI_09380COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (443 aa)
LKI_09395Hypothetical protein. (148 aa)
LKI_09915Hypothetical protein; COG0212 5-formyltetrahydrofolate cyclo-ligase. (327 aa)
LKI_02545Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (449 aa)
murDUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (448 aa)
guaABifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (515 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
purCCOG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (247 aa)
purSConserved purine biosynthesis cluster protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (88 aa)
Your Current Organism:
Leuconostoc kimchii
NCBI taxonomy Id: 762051
Other names: L. kimchii IMSNU 11154, Leuconostoc kimchii IMSNU 11154, Leuconostoc kimchii str. IMSNU 11154, Leuconostoc kimchii strain IMSNU 11154
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