STRINGSTRING
LKI_06405 LKI_06405 LKI_01570 LKI_01570 LKI_01565 LKI_01565 LKI_01445 LKI_01445 LKI_01300 LKI_01300 pyrB pyrB pyrC pyrC carA carA carB carB pyrD pyrD pyrF pyrF pyrE pyrE pyrH pyrH LKI_00355 LKI_00355 LKI_02215 LKI_02215 upp upp coaD coaD udk udk LKI_02940 LKI_02940 xpt xpt LKI_04205 LKI_04205 prs prs ackA ackA LKI_05300 LKI_05300 LKI_05305 LKI_05305 accD accD LKI_05315 LKI_05315 coaE coaE atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC purD purD adk adk LKI_07425 LKI_07425 pyrG pyrG LKI_08065 LKI_08065 dacA dacA purA purA apt apt LKI_08735 LKI_08735 carA-2 carA-2 carB-2 carB-2 LKI_09080 LKI_09080 LKI_09165 LKI_09165 ackA-2 ackA-2 LKI_09935 LKI_09935 purE purE purK purK purC purC purS purS purQ purQ purL purL purF purF purM purM purN purN purH purH guaA guaA LKI_02010 LKI_02010
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LKI_06405COG1072 Panthothenate kinase. (224 aa)
LKI_01570COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa)
LKI_01565COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (187 aa)
LKI_01445Ribose-phosphate pyrophosphokinase; COG0462 Phosphoribosylpyrophosphate synthetase. (324 aa)
LKI_01300Pantothenate metabolism flavoprotein Dfp; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa)
pyrBCOG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (303 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (421 aa)
carACOG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (362 aa)
carBCOG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (1059 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit (dihydroorotateoxidase); Catalyzes the conversion of dihydroorotate to orotate. (306 aa)
pyrFHypothetical protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (208 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
LKI_00355COG0439 Biotin carboxylase. (446 aa)
LKI_02215Probable lyase; COG0015 Adenylosuccinate lyase. (448 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (158 aa)
udkCOG0572 Uridine kinase. (213 aa)
LKI_02940COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (427 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa)
LKI_04205DNA topology modulation protein FLAR-related protein; COG0563 Adenylate kinase and related kinases. (160 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (419 aa)
LKI_05300COG0439 Biotin carboxylase. (389 aa)
LKI_05305acetyl-CoA carboxylase beta subunit; COG0439 Biotin carboxylase. (55 aa)
accDacetyl-CoA carboxylase, carboxyl transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (279 aa)
LKI_05315COG0825 Acetyl-CoA carboxylase alpha subunit. (266 aa)
coaEHypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa)
atpBATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (241 aa)
atpEH(+)-transporting two-sector ATPase, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa)
atpFH(+)-transporting two-sector ATPase, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (169 aa)
atpHATP synthase delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa)
atpAATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa)
atpGH(+)-transporting two-sector ATPase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (302 aa)
atpDATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (466 aa)
atpCH(+)-transporting two-sector ATPase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (149 aa)
purDCOG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (414 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (187 aa)
LKI_07425COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
LKI_08065COG0105 Nucleoside diphosphate kinase. (137 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (271 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
LKI_08735GTP pyrophosphokinase (putative); COG2357 Uncharacterized protein conserved in bacteria. (192 aa)
carA-2COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (360 aa)
carB-2COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. (837 aa)
LKI_09080GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (749 aa)
LKI_09165Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (314 aa)
ackA-2Acetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (415 aa)
LKI_09935Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (312 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
purCCOG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (247 aa)
purSConserved purine biosynthesis cluster protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (88 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (740 aa)
purFAmidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (536 aa)
purMCOG0150 Phosphoribosylaminoimidazole (AIR) synthetase. (345 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (196 aa)
purHBifunctional protein: phosphoribosylaminoimidazolecarboxamideformyltransferase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). (508 aa)
guaABifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (515 aa)
LKI_02010COG0516 IMP dehydrogenase/GMP reductase. (390 aa)
Your Current Organism:
Leuconostoc kimchii
NCBI taxonomy Id: 762051
Other names: L. kimchii IMSNU 11154, Leuconostoc kimchii IMSNU 11154, Leuconostoc kimchii str. IMSNU 11154, Leuconostoc kimchii strain IMSNU 11154
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