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EGF57730.1 EGF57730.1 EGF57738.1 EGF57738.1 EGF57739.1 EGF57739.1 EGF57740.1 EGF57740.1 EGF55914.1 EGF55914.1 sucC sucC sucD sucD mdh mdh EGF55213.1 EGF55213.1 EGF55214.1 EGF55214.1 EGF55215.1 EGF55215.1 fumC fumC EGF55438.1 EGF55438.1 pckG pckG EGF53678.1 EGF53678.1 ldh ldh EGF50021.1 EGF50021.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGF57730.1KEGG: ahe:Arch_1433 1.3e-160 citrate synthase I K01647; Psort location: Cytoplasmic, score: 9.95. (476 aa)
EGF57738.1KEGG: pak:HMPREF0675_4009 1.4e-99 succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240 succinate dehydrogenase iron-sulfur protein; Psort location: Cytoplasmic, score: 9.89. (251 aa)
EGF57739.1KEGG: pak:HMPREF0675_4008 9.6e-282 sdhA; succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89. (653 aa)
EGF57740.1Succinate dehydrogenase cytochrome B subunit, b558 family; KEGG: pfr:PFREUD_09240 6.6e-61 sdhC1; succinate dehydrogenase subunit C K00241; Psort location: CytoplasmicMembrane, score: 10.00. (257 aa)
EGF55914.1KEGG: nca:Noca_3575 2.6e-256 isocitrate dehydrogenase, NADP-dependent K00031; Psort location: Cytoplasmic, score: 9.97; Belongs to the monomeric-type IDH family. (755 aa)
sucCsuccinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (401 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (313 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
EGF55213.1KEGG: ahe:Arch_1332 9.8e-51 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; K00241 succinate dehydrogenase cytochrome b-556 subunit; Psort location: CytoplasmicMembrane, score: 10.00. (250 aa)
EGF55214.1KEGG: ahe:Arch_1331 8.5e-290 succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89. (666 aa)
EGF55215.1KEGG: ahe:Arch_1330 2.5e-100 succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240 succinate dehydrogenase iron-sulfur protein; Psort location: Cytoplasmic, score: 9.89. (256 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (478 aa)
EGF55438.1NAD-dependent malic enzyme; KEGG: nca:Noca_2034 7.6e-147 malate dehydrogenase K00027; Psort location: Cytoplasmic, score: 7.50. (462 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (615 aa)
EGF53678.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
EGF50021.1Pyruvate, phosphate dikinase; KEGG: mcu:HMPREF0573_10425 0. ppdK; pyruvate phosphate dikinase K01006; Psort location: Cytoplasmic, score: 9.97; Belongs to the PEP-utilizing enzyme family. (901 aa)
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
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