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EGF53559.1 EGF53559.1 EGF57309.1 EGF57309.1 prs prs EGF57810.1 EGF57810.1 EGF57772.1 EGF57772.1 EGF57740.1 EGF57740.1 EGF57739.1 EGF57739.1 EGF57738.1 EGF57738.1 EGF57730.1 EGF57730.1 EGF57693.1 EGF57693.1 EGF57689.1 EGF57689.1 EGF57688.1 EGF57688.1 EGF57687.1 EGF57687.1 EGF58242.1 EGF58242.1 EGF58174.1 EGF58174.1 EGF56964.1 EGF56964.1 serC serC EGF56798.1 EGF56798.1 EGF56812.1 EGF56812.1 EGF56583.1 EGF56583.1 EGF56630.1 EGF56630.1 EGF56248.1 EGF56248.1 EGF56270.1 EGF56270.1 EGF56274.1 EGF56274.1 EGF56275.1 EGF56275.1 EGF56179.1 EGF56179.1 EGF55914.1 EGF55914.1 EGF55921.1 EGF55921.1 EGF55958.1 EGF55958.1 sucC sucC sucD sucD mdh mdh EGF55619.1 EGF55619.1 EGF55554.1 EGF55554.1 EGF55189.1 EGF55189.1 EGF55213.1 EGF55213.1 EGF55214.1 EGF55214.1 EGF55215.1 EGF55215.1 ackA ackA EGF55241.1 EGF55241.1 EGF55254.1 EGF55254.1 EGF55255.1 EGF55255.1 EGF55258.1 EGF55258.1 EGF55268.1 EGF55268.1 glyA glyA folD folD fumC fumC EGF55438.1 EGF55438.1 EGF54778.1 EGF54778.1 gpmA gpmA EGF54308.1 EGF54308.1 EGF54364.1 EGF54364.1 EGF54372.1 EGF54372.1 EGF54375.1 EGF54375.1 EGF54376.1 EGF54376.1 EGF53496.1 EGF53496.1 EGF53502.1 EGF53502.1 EGF53503.1 EGF53503.1 EGF53504.1 EGF53504.1 pfkA pfkA EGF57001.1 EGF57001.1 zwf zwf pgl pgl pgi pgi tpiA tpiA pgk pgk EGF53582.1 EGF53582.1 EGF53614.1 EGF53614.1 EGF53670.1 EGF53670.1 EGF53678.1 EGF53678.1 EGF53733.1 EGF53733.1 EGF53825.1 EGF53825.1 EGF53829.1 EGF53829.1 EGF52225.1 EGF52225.1 fhs fhs EGF51819.1 EGF51819.1 EGF51723.1 EGF51723.1 eno eno ilvA ilvA EGF49977.1 EGF49977.1 EGF50009.1 EGF50009.1 EGF50021.1 EGF50021.1 EGF49896.1 EGF49896.1 EGF49933.1 EGF49933.1 EGF49939.1 EGF49939.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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EGF53559.1Phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (491 aa)
EGF57309.1HAD hydrolase, family IB; KEGG: cgl:NCgl0294 2.0e-43 cgl0299; phosphoserine phosphatase K01079. (330 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (330 aa)
EGF57810.1Hypothetical protein. (180 aa)
EGF57772.1ROK family protein; KEGG: fre:Franean1_1825 3.4e-20 ROK family glucokinase; K00845 glucokinase; Psort location: Cytoplasmic, score: 9.97. (365 aa)
EGF57740.1Succinate dehydrogenase cytochrome B subunit, b558 family; KEGG: pfr:PFREUD_09240 6.6e-61 sdhC1; succinate dehydrogenase subunit C K00241; Psort location: CytoplasmicMembrane, score: 10.00. (257 aa)
EGF57739.1KEGG: pak:HMPREF0675_4008 9.6e-282 sdhA; succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89. (653 aa)
EGF57738.1KEGG: pak:HMPREF0675_4009 1.4e-99 succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240 succinate dehydrogenase iron-sulfur protein; Psort location: Cytoplasmic, score: 9.89. (251 aa)
EGF57730.1KEGG: ahe:Arch_1433 1.3e-160 citrate synthase I K01647; Psort location: Cytoplasmic, score: 9.95. (476 aa)
EGF57693.1KEGG: bcv:Bcav_1505 3.8e-33 ribose 5-phosphate isomerase; K01808 ribose 5-phosphate isomerase B; Psort location: Cytoplasmic, score: 7.50. (149 aa)
EGF57689.1Hypothetical protein; KEGG: pfr:PFREUD_09310 1.5e-14 lpdB; dihydrolipoyl dehydrogenase (E3 component of alpha keto acid dehydrogenase complexes) (dihydrolipoamide dehydrogenase) K00382. (63 aa)
EGF57688.1Pyridine nucleotide-disulfide oxidoreductase. (225 aa)
EGF57687.1Hypothetical protein. (101 aa)
EGF58242.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (917 aa)
EGF58174.1KEGG: ahe:Arch_0735 5.0e-111 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Psort location: Cytoplasmic, score: 9.97. (322 aa)
EGF56964.1KEGG: ske:Sked_33270 1.3e-142 L-serine ammonia-lyase; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 7.50. (564 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (395 aa)
EGF56798.14-phosphoerythronate dehydrogenase; KEGG: hha:Hhal_0569 1.7e-119 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; K00058 D-3-phosphoglycerate dehydrogenase; Psort location: Cytoplasmic, score: 9.97. (396 aa)
EGF56812.1Hypothetical protein; Psort location: Cytoplasmic, score: 7.50. (99 aa)
EGF56583.1Glucokinase; KEGG: tcu:Tcur_3047 4.9e-88 glucokinase, ROK family; K00845 glucokinase; Psort location: Cytoplasmic, score: 9.97. (315 aa)
EGF56630.1Cysteine-rich domain protein; KEGG: nda:Ndas_5473 1.2e-157 CoB--CoM heterodisulfide reductase; Psort location: CytoplasmicMembrane, score: 9.55. (817 aa)
EGF56248.1Putative ferrous iron permease EfeU; KEGG: ccv:CCV52592_0433 2.9e-18 fumarate hydratase class II (fumarase C) K01679; Psort location: CytoplasmicMembrane, score: 10.00. (312 aa)
EGF56270.1Carbamate kinase; KEGG: mta:Moth_2117 6.7e-84 carbamate kinase K00926; Psort location: Cytoplasmic, score: 7.50. (315 aa)
EGF56274.1Transketolase, thiamine diphosphate binding domain protein; KEGG: fnu:FN0294 6.6e-77 transketolase subunit A K00615; Psort location: Cytoplasmic, score: 7.50. (274 aa)
EGF56275.1Transketolase, pyridine binding domain protein; KEGG: hmo:HM1_1269 4.6e-85 tktC; transketolase, C-terminal subunit; K00615 transketolase; Psort location: Cytoplasmic, score: 7.50. (313 aa)
EGF56179.1KEGG: mcu:HMPREF0573_10038 7.7e-83 ppgK; polyphosphate--glucose phosphotransferase K00886; Psort location: Cytoplasmic, score: 9.67. (248 aa)
EGF55914.1KEGG: nca:Noca_3575 2.6e-256 isocitrate dehydrogenase, NADP-dependent K00031; Psort location: Cytoplasmic, score: 9.97; Belongs to the monomeric-type IDH family. (755 aa)
EGF55921.1KEGG: ske:Sked_09540 0. 2-oxoglutarate dehydrogenase E1 component; K00164 2-oxoglutarate dehydrogenase E1 component; Psort location: Cytoplasmic, score: 9.97. (1268 aa)
EGF55958.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (788 aa)
sucCsuccinate-CoA ligase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (401 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (313 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
EGF55619.1Dihydrolipoyl dehydrogenase; KEGG: ahe:Arch_0736 1.9e-166 dihydrolipoamide dehydrogenase; K00382 dihydrolipoamide dehydrogenase; Psort location: Cytoplasmic, score: 9.97. (457 aa)
EGF55554.1Biotin-requiring enzyme; KEGG: xce:Xcel_2030 6.2e-49 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase K00658; Psort location: Cytoplasmic, score: 9.67. (145 aa)
EGF55189.1ROK family protein; KEGG: bcv:Bcav_3110 2.3e-97 ROK family protein; K00886 polyphosphate glucokinase; Psort location: Cytoplasmic, score: 9.97. (244 aa)
EGF55213.1KEGG: ahe:Arch_1332 9.8e-51 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; K00241 succinate dehydrogenase cytochrome b-556 subunit; Psort location: CytoplasmicMembrane, score: 10.00. (250 aa)
EGF55214.1KEGG: ahe:Arch_1331 8.5e-290 succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239; Psort location: Cytoplasmic, score: 9.89. (666 aa)
EGF55215.1KEGG: ahe:Arch_1330 2.5e-100 succinate dehydrogenase and fumarate reductase iron-sulfur protein; K00240 succinate dehydrogenase iron-sulfur protein; Psort location: Cytoplasmic, score: 9.89. (256 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
EGF55241.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (684 aa)
EGF55254.1Transaldolase; KEGG: pfr:PFREUD_19040 6.2e-168 tal2; transaldolase 2 K00616; Psort location: Cytoplasmic, score: 7.50. (367 aa)
EGF55255.1UbiC transcription regulator-associated domain protein; KEGG: xne:XNC1_0089 4.4e-16 GntR-family transcriptional regulator; Psort location: Cytoplasmic, score: 7.50. (250 aa)
EGF55258.1Hypothetical protein; KEGG: mrb:Mrub_1277 4.0e-06 deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; K01623 fructose-bisphosphate aldolase, class I; Psort location: Cytoplasmic, score: 7.50. (309 aa)
EGF55268.1GroES-like protein; KEGG: pfr:PFREUD_19130 2.5e-155 zinc-containing alcohol dehydrogenase superfamily K00121; Psort location: Cytoplasmic, score: 9.97. (388 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (436 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (478 aa)
EGF55438.1NAD-dependent malic enzyme; KEGG: nca:Noca_2034 7.6e-147 malate dehydrogenase K00027; Psort location: Cytoplasmic, score: 7.50. (462 aa)
EGF54778.1Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (349 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa)
EGF54308.1KEGG: lsg:lse_2221 9.0e-09 transcriptional regulator, GntR family K07979. (131 aa)
EGF54364.1UbiC transcription regulator-associated domain protein; KEGG: reh:H16_A3019 2.5e-20 hutC; histidine utilization repressor K05836; Psort location: Cytoplasmic, score: 7.50. (249 aa)
EGF54372.1KEGG: ske:Sked_24510 1.1e-56 ribose 5-phosphate isomerase; K01808 ribose 5-phosphate isomerase B; Psort location: Cytoplasmic, score: 7.50. (170 aa)
EGF54375.1KEGG: bcv:Bcav_2610 3.3e-59 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. (191 aa)
EGF54376.1KEGG: cfl:Cfla_1390 9.2e-103 cysteine synthase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 7.50; Belongs to the cysteine synthase/cystathionine beta- synthase family. (316 aa)
EGF53496.1Carbamate kinase; KEGG: mcu:HMPREF0573_11901 5.7e-126 carbamate kinase K00926; Psort location: Cytoplasmic, score: 7.50. (326 aa)
EGF53502.1Ribulose-phosphate 3-epimerase; KEGG: mlu:Mlut_10820 1.6e-66 ribulose-5-phosphate 3-epimerase K01783; Psort location: Cytoplasmic, score: 7.50; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa)
EGF53503.1KEGG: gva:HMPREF0424_1199 2.7e-158 carbamoyl-phosphate synthase L chain, ATP binding domain protein; K11263 acetyl-/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein; Psort location: Cytoplasmic, score: 9.97. (616 aa)
EGF53504.1Carboxyl transferase domain protein; KEGG: bde:BDP_0361 5.2e-164 accD; AccD acetyl-/propionyl-CoA carboxylase beta chain; Psort location: Cytoplasmic, score: 7.50. (522 aa)
pfkAPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (373 aa)
EGF57001.1KEGG: bcv:Bcav_0238 4.9e-49 methylenetetrahydrofolate reductase (NAD(P)H) K00297; Psort location: Cytoplasmic, score: 7.50. (463 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (487 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (264 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (551 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (401 aa)
EGF53582.1Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
EGF53614.1Pyruvate kinase; KEGG: bcv:Bcav_2215 1.4e-179 pyruvate kinase K00873; Psort location: Cytoplasmic, score: 7.50. (476 aa)
EGF53670.1Putative dihydrolipoyl dehydrogenase; KEGG: rcu:RCOM_0056870 1.8e-106 mercuric reductase, putative; Psort location: Cytoplasmic, score: 9.97. (483 aa)
EGF53678.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
EGF53733.1KEGG: xce:Xcel_1419 1.1e-56 phosphoserine phosphatase SerB K01079; Psort location: Cytoplasmic, score: 7.50. (249 aa)
EGF53825.1KEGG: mcu:HMPREF0573_11354 5.6e-48 putative phosphoglycerate mutase K01834; Psort location: Cytoplasmic, score: 7.50. (213 aa)
EGF53829.1ROK family protein; KEGG: bcv:Bcav_3538 1.2e-29 ROK family protein; K00845 glucokinase; Psort location: Cytoplasmic, score: 7.50. (350 aa)
EGF52225.1ROK family protein; KEGG: bcv:Bcav_3770 6.2e-81 ROK family protein; K00845 glucokinase; Psort location: Cytoplasmic, score: 9.97. (344 aa)
fhsKEGG: pac:PPA0049 1.9e-175 formate--tetrahydrofolate ligase K01938; Psort location: Cytoplasmic, score: 7.50. (579 aa)
EGF51819.1ROK family protein; KEGG: bde:BDP_2227 4.6e-37 transcriptional repressor, ROK family; Psort location: Cytoplasmic, score: 9.97. (360 aa)
EGF51723.1KEGG: xce:Xcel_2303 1.7e-135 glyceraldehyde-3-phosphate dehydrogenase, type I; Psort location: Cytoplasmic, score: 9.97. (334 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
ilvAThreonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (539 aa)
EGF49977.1Putative gluconokinase; KEGG: cfl:Cfla_0786 3.3e-50 carbohydrate kinase, thermoresistant glucokinase family K00851. (175 aa)
EGF50009.1KEGG: tbi:Tbis_0816 1.3e-78 pyridoxal-5'-phosphate-dependent protein beta subunit; K01754 threonine dehydratase; Psort location: Cytoplasmic, score: 7.50. (340 aa)
EGF50021.1Pyruvate, phosphate dikinase; KEGG: mcu:HMPREF0573_10425 0. ppdK; pyruvate phosphate dikinase K01006; Psort location: Cytoplasmic, score: 9.97; Belongs to the PEP-utilizing enzyme family. (901 aa)
EGF49896.1KEGG: mlu:Mlut_00880 4.5e-142 glutamate dehydrogenase/leucine dehydrogenase K00261; Psort location: Cytoplasmic, score: 9.97; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (416 aa)
EGF49933.1Transketolase; KEGG: ahe:Arch_0880 3.4e-222 transketolase; K00615 transketolase; Psort location: Cytoplasmic, score: 7.50; Belongs to the transketolase family. (707 aa)
EGF49939.1Kinase, PfkB family; KEGG: pak:HMPREF0675_3940 7.4e-101 putative 2-keto-3-deoxygluconate kinase K00874; Psort location: Cytoplasmic, score: 7.50. (316 aa)
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
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