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EFY07032.1 EFY07032.1 pdxJ pdxJ EFY07140.1 EFY07140.1 EFY06079.1 EFY06079.1 pdxB-7 pdxB-7 thiC thiC thiE thiE thiS thiS thiG thiG thiH thiH EFY07125.1 EFY07125.1 folC folC pdxA-2 pdxA-2 pdxB-3 pdxB-3 pdxA pdxA ribF ribF EFY06487.1 EFY06487.1 EFY07589.1 EFY07589.1 EFY07588.1 EFY07588.1 ribA ribA EFY08153.1 EFY08153.1 EFY08122.1 EFY08122.1 folB folB folK folK folK-2 folK-2 bioA bioA EFY07849.1 EFY07849.1 bioB bioB bioD bioD thiM thiM pdxH pdxH serC serC EFY06529.1 EFY06529.1 EFY06590.1 EFY06590.1 EFY06585.1 EFY06585.1 thiI thiI dxs dxs thiL thiL ribH ribH ribE ribE ribD ribD gap gap folP folP EFY06952.1 EFY06952.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
EFY07032.1KEGG: epy:EpC_34350 2.7e-23 bioH; carboxylesterase (biotin synthesis protein BioH) K02170; Psort location: Cytoplasmic, score: 9.97. (259 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (245 aa)
EFY07140.1Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (529 aa)
EFY06079.1KEGG: shn:Shewana3_1024 6.4e-31 dihydropteroate synthase K00796; Psort location: Cytoplasmic, score: 9.97. (280 aa)
pdxB-74-phosphoerythronate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (386 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (504 aa)
thiEThiamine-phosphate diphosphorylase; KEGG: aha:AHA_0440 9.5e-85 thiamine monophosphate synthase; K14153 hydroxymethylpyrimidine kinase / phosphomethylpyrimidine kinase / thiamine-phosphate diphosphorylase; Psort location: Cytoplasmic, score: 8.96. (498 aa)
thiSThiamine biosynthesis protein ThiS. (66 aa)
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)
thiHKEGG: ddd:Dda3937_00230 1.2e-98 thiH, thiA; thiamin biosynthesis ThiGH complex subunit K03150; Psort location: Cytoplasmic, score: 8.96. (374 aa)
EFY07125.1Oxidoreductase, aldo/keto reductase family protein; KEGG: lsl:LSL_1681 4.0e-86 2,5-diketo-D-gluconic acid reductase K05885; Psort location: Cytoplasmic, score: 9.97. (280 aa)
folCKEGG: ddc:Dd586_2770 2.1e-73 FolC bifunctional protein K11754; Psort location: Cytoplasmic, score: 9.97; Belongs to the folylpolyglutamate synthase family. (437 aa)
pdxA-2KEGG: rpi:Rpic_0564 6.7e-116 4-hydroxythreonine-4-phosphate dehydrogenase K00097; Psort location: Cytoplasmic, score: 9.97; Belongs to the PdxA family. (794 aa)
pdxB-3KEGG: bfs:BF1389 2.0e-114 ldhA, hslI, htpH; D-lactate dehydrogenase K03778; Psort location: Cytoplasmic, score: 9.97; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (328 aa)
ribFKEGG: hdu:HD0273 1.4e-65 ribF; riboflavin biosynthesis protein RibF; K11753 riboflavin kinase / FMN adenylyltransferase; Psort location: Cytoplasmic, score: 9.97. (318 aa)
EFY06487.1Oxidoreductase, aldo/keto reductase family protein; KEGG: bsu:BSU29050 3.1e-63 ytbE; putative aldo/keto reductase; Psort location: Cytoplasmic, score: 9.97. (287 aa)
EFY07589.1Oxidoreductase, aldo/keto reductase family protein; KEGG: afn:Acfer_0525 1.3e-89 2,5-didehydrogluconate reductase; Psort location: Cytoplasmic, score: 9.97; overlaps another CDS with the same product name. (282 aa)
EFY07588.1Oxidoreductase, aldo/keto reductase family protein; KEGG: coc:Coch_1297 2.3e-90 2,5-didehydrogluconate reductase; Psort location: Cytoplasmic, score: 9.97; overlaps another CDS with the same product name. (290 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (199 aa)
EFY08153.1Hypothetical protein; KEGG: fbl:Fbal_3339 1.4e-17 coproporphyrinogen dehydrogenase. (168 aa)
EFY08122.1Oxidoreductase, aldo/keto reductase family protein; KEGG: tmt:Tmath_1400 1.3e-85 aldehyde reductase; Psort location: Cytoplasmic, score: 9.97. (291 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
folKKEGG: tau:Tola_2665 3.5e-23 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Psort location: Cytoplasmic, score: 9.97. (179 aa)
folK-2KEGG: ter:Tery_0688 1.9e-31 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950; Psort location: Cytoplasmic, score: 9.26. (165 aa)
bioAKEGG: bth:BT_1442 1.5e-143 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; K00833 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
EFY07849.1KEGG: acd:AOLE_15630 1.2e-79 8-amino-7-oxononanoate synthase K00652; Psort location: Cytoplasmic, score: 9.97. (388 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (349 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (227 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (268 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (202 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
EFY06529.1Oxidoreductase, aldo/keto reductase family protein; KEGG: cpy:Cphy_1752 4.4e-64 2,5-didehydrogluconate reductase; Psort location: Cytoplasmic, score: 9.26. (294 aa)
EFY06590.1RibD domain family protein; KEGG: mno:Mnod_6142 2.2e-37 putative 5-amino-6-(5-phosphoribosylamino)uracil reductase; K00082 5-amino-6-(5-phosphoribosylamino)uracil reductase; Psort location: Cytoplasmic, score: 8.96. (230 aa)
EFY06585.1Oxidoreductase, aldo/keto reductase family protein; KEGG: amu:Amuc_1800 8.2e-63 2,5-didehydrogluconate reductase; Psort location: Cytoplasmic, score: 9.97. (266 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (487 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (626 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa)
ribEKEGG: tau:Tola_2524 4.5e-55 riboflavin synthase, alpha subunit K00793; Psort location: Cytoplasmic, score: 9.26. (223 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (366 aa)
gapKEGG: pat:Patl_1634 9.4e-133 glyceraldehyde-3-phosphate dehydrogenase, type I K00134; Psort location: Cytoplasmic, score: 9.97. (336 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (277 aa)
EFY06952.1Cof-like hydrolase; KEGG: cbk:CLL_A2915 3.5e-46 phosphatase YidA K07024; Psort location: Cytoplasmic, score: 8.96. (279 aa)
Your Current Organism:
Succinatimonas hippei
NCBI taxonomy Id: 762983
Other names: Anaerobiospirillum sp. YIT 12066, S. hippei YIT 12066, Succinatimonas hippei DSM 22608, Succinatimonas hippei JCM 16073, Succinatimonas hippei YIT 12066, Succinatimonas hippei str. YIT 12066, Succinatimonas hippei strain YIT 12066
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