(34 nodes) Mixed, incl. Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex network (Phycomyces blakesleeanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	A0A162N8T1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (249 aa)
	A0A162NEM1	BUB1 N-terminal domain-containing protein. (600 aa)
	Chk2	Checkpoint kinase 2-like protein. (559 aa)
	A0A162NJ37	USP domain-containing protein. (334 aa)
	A0A162NL31	WD_REPEATS_REGION domain-containing protein. (416 aa)
	PHYBLDRAFT_556	AA_TRNA_LIGASE_II_ALA domain-containing protein. (716 aa)
	ALA1	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (958 aa)
	Plo1	Serine/threonine protein kinase. (249 aa)
	A0A162UIA5	Protein kinase domain-containing protein. (299 aa)
	A0A162UJZ9	Mitotic cyclin; Belongs to the cyclin family. (266 aa)
	A0A162UT61	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (240 aa)
	A0A162UYZ7	WD_REPEATS_REGION domain-containing protein. (226 aa)
	A0A162XMS8	TPR_REGION domain-containing protein. (607 aa)
	A0A162XPD4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (255 aa)
	A0A162Y7E4	Uncharacterized protein. (696 aa)
	A0A162Y8G0	Protein kinase domain-containing protein. (205 aa)
	A0A162ZZV2	Uncharacterized protein. (716 aa)
	A0A163AJJ8	Ras-GAP domain-containing protein. (2593 aa)
	A0A163AXL1	RING-type domain-containing protein. (89 aa)
	A0A163E007	USP domain-containing protein. (579 aa)
	A0A163EPI0	HORMA domain-containing protein. (185 aa)
	A0A167J644	Ras-GAP domain-containing protein. (1703 aa)
	A0A167K4T5	TPR_REGION domain-containing protein. (579 aa)
	A0A167KHB9	Cdk1/5 group protein; Belongs to the protein kinase superfamily. (293 aa)
	A0A167KQ37	WD_REPEATS_REGION domain-containing protein. (352 aa)
	A0A167L3S1	Ras-GAP domain-containing protein. (1301 aa)
	A0A167MN13	WD_REPEATS_REGION domain-containing protein. (332 aa)
	A0A167N8N2	Cullin; Belongs to the cullin family. (433 aa)
	A0A167NI31	Uncharacterized protein. (685 aa)
	A0A167NNZ2	WD_REPEATS_REGION domain-containing protein. (336 aa)
	A0A167NVR9	Uncharacterized protein. (706 aa)
	A0A167QJ20	Uncharacterized protein. (598 aa)
	A0A167QJF1	WD_REPEATS_REGION domain-containing protein. (424 aa)
	A0A167QYL0	Rhodanese domain-containing protein. (134 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162N8T1	A0A162NL31	A0A162N8T1	A0A162NL31	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.406
A0A162N8T1	A0A162UJZ9	A0A162N8T1	A0A162UJZ9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitotic cyclin; Belongs to the cyclin family.	0.484
A0A162N8T1	A0A162UT61	A0A162N8T1	A0A162UT61	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.562
A0A162N8T1	A0A162XPD4	A0A162N8T1	A0A162XPD4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.909
A0A162N8T1	A0A162Y7E4	A0A162N8T1	A0A162Y7E4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.443
A0A162N8T1	A0A162ZZV2	A0A162N8T1	A0A162ZZV2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.469
A0A162N8T1	A0A163AXL1	A0A162N8T1	A0A163AXL1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RING-type domain-containing protein.	0.457
A0A162N8T1	A0A167K4T5	A0A162N8T1	A0A167K4T5	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	TPR_REGION domain-containing protein.	0.569
A0A162N8T1	A0A167KHB9	A0A162N8T1	A0A167KHB9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cdk1/5 group protein; Belongs to the protein kinase superfamily.	0.496
A0A162N8T1	A0A167KQ37	A0A162N8T1	A0A167KQ37	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.654
A0A162N8T1	A0A167MN13	A0A162N8T1	A0A167MN13	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.406
A0A162N8T1	A0A167N8N2	A0A162N8T1	A0A167N8N2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cullin; Belongs to the cullin family.	0.443
A0A162N8T1	A0A167NVR9	A0A162N8T1	A0A167NVR9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.475
A0A162N8T1	A0A167QJ20	A0A162N8T1	A0A167QJ20	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.449
A0A162N8T1	A0A167QJF1	A0A162N8T1	A0A167QJF1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.406
A0A162N8T1	A0A167QYL0	A0A162N8T1	A0A167QYL0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Rhodanese domain-containing protein.	0.741
A0A162N8T1	ALA1	A0A162N8T1	A0A162TTV4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.	0.408
A0A162N8T1	PHYBLDRAFT_556	A0A162N8T1	A0A162Q0D7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	AA_TRNA_LIGASE_II_ALA domain-containing protein.	0.408
A0A162NEM1	A0A162NL31	A0A162NEM1	A0A162NL31	BUB1 N-terminal domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.839
A0A162NEM1	A0A162UJZ9	A0A162NEM1	A0A162UJZ9	BUB1 N-terminal domain-containing protein.	Mitotic cyclin; Belongs to the cyclin family.	0.927