(37 nodes) Endoplasmic reticulum organization network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GET1	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. (184 aa)
	A0A162UXK1	Uncharacterized protein. (1222 aa)
	A0A162UUY8	Uncharacterized protein. (116 aa)
	GET3	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (333 aa)
	A0A162UQA7	Uncharacterized protein. (1253 aa)
	A0A162UG19	Uncharacterized protein. (286 aa)
	A0A162TS87	Uncharacterized protein. (111 aa)
	A0A162Q5R2	Zinc_ribbon_10 domain-containing protein. (253 aa)
	A0A162PZM0	Uncharacterized protein. (322 aa)
	A0A162NF25	Zinc_ribbon_10 domain-containing protein. (319 aa)
	A0A162N632	Ubiquitin-like domain-containing protein. (458 aa)
	A0A162N5U0	MPN domain-containing protein. (198 aa)
	A0A162N2F7	L-type lectin-like domain-containing protein. (481 aa)
	A0A162UB26	Protein YOP1. (86 aa)
	A0A167Q563	Uncharacterized protein. (262 aa)
	A0A167PIU1	Uncharacterized protein. (197 aa)
	A0A167P2B0	Uncharacterized protein. (1411 aa)
	A0A167NIQ4	Protein YOP1. (191 aa)
	A0A167NBT8	Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (838 aa)
	A0A167N9S4	Protein YOP1. (145 aa)
	A0A167N4F1	L-type lectin-like domain-containing protein. (309 aa)
	A0A167MP98	L-type lectin-like domain-containing protein. (268 aa)
	A0A167M7F2	Uncharacterized protein. (844 aa)
	A0A167LPU8	MSP domain-containing protein. (272 aa)
	A0A167LKW5	C2 domain-containing protein. (122 aa)
	A0A167LKU7	Uncharacterized protein. (802 aa)
	A0A167LFA7	Uncharacterized protein. (1019 aa)
	A0A167L7M5	Uncharacterized protein. (1449 aa)
	A0A167JTK4	Uncharacterized protein. (137 aa)
	A0A167JH14	DUF2012 domain-containing protein. (201 aa)
	A0A163DKZ7	Uncharacterized protein. (225 aa)
	A0A163DGM7	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (274 aa)
	SEY1	Protein SEY1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (776 aa)
	A0A163AK08	Uncharacterized protein. (771 aa)
	A0A163A6Y6	Sec3-PIP2_bind domain-containing protein. (1069 aa)
	A0A162ZNI2	Uncharacterized protein. (249 aa)
	A0A162V3K8	MSP domain-containing protein. (241 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162N2F7	A0A162V3K8	A0A162N2F7	A0A162V3K8	L-type lectin-like domain-containing protein.	MSP domain-containing protein.	0.668
A0A162N2F7	A0A163DGM7	A0A162N2F7	A0A163DGM7	L-type lectin-like domain-containing protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.746
A0A162N2F7	A0A167LPU8	A0A162N2F7	A0A167LPU8	L-type lectin-like domain-containing protein.	MSP domain-containing protein.	0.668
A0A162N2F7	A0A167MP98	A0A162N2F7	A0A167MP98	L-type lectin-like domain-containing protein.	L-type lectin-like domain-containing protein.	0.744
A0A162N2F7	A0A167N4F1	A0A162N2F7	A0A167N4F1	L-type lectin-like domain-containing protein.	L-type lectin-like domain-containing protein.	0.744
A0A162N5U0	A0A162TS87	A0A162N5U0	A0A162TS87	MPN domain-containing protein.	Uncharacterized protein.	0.926
A0A162N5U0	A0A163DGM7	A0A162N5U0	A0A163DGM7	MPN domain-containing protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.952
A0A162N5U0	A0A167JH14	A0A162N5U0	A0A167JH14	MPN domain-containing protein.	DUF2012 domain-containing protein.	0.915
A0A162N632	A0A162PZM0	A0A162N632	A0A162PZM0	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.983
A0A162N632	GET3	A0A162N632	A0A162UUY1	Ubiquitin-like domain-containing protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.826
A0A162NF25	A0A162UB26	A0A162NF25	A0A162UB26	Zinc_ribbon_10 domain-containing protein.	Protein YOP1.	0.514
A0A162NF25	SEY1	A0A162NF25	A0A163AQR6	Zinc_ribbon_10 domain-containing protein.	Protein SEY1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	0.515
A0A162PZM0	A0A162N632	A0A162PZM0	A0A162N632	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.983
A0A162PZM0	GET1	A0A162PZM0	A0A162V396	Uncharacterized protein.	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.653
A0A162PZM0	GET3	A0A162PZM0	A0A162UUY1	Uncharacterized protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.994
A0A162Q5R2	A0A162UB26	A0A162Q5R2	A0A162UB26	Zinc_ribbon_10 domain-containing protein.	Protein YOP1.	0.514
A0A162Q5R2	SEY1	A0A162Q5R2	A0A163AQR6	Zinc_ribbon_10 domain-containing protein.	Protein SEY1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	0.515
A0A162TS87	A0A162N5U0	A0A162TS87	A0A162N5U0	Uncharacterized protein.	MPN domain-containing protein.	0.926
A0A162TS87	A0A163DGM7	A0A162TS87	A0A163DGM7	Uncharacterized protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.958
A0A162TS87	A0A167JH14	A0A162TS87	A0A167JH14	Uncharacterized protein.	DUF2012 domain-containing protein.	0.956