(25 nodes) Endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5-phosphomonoesters network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A163BD10	RNase H domain-containing protein. (369 aa)
	A0A163B808	MKT1_C domain-containing protein. (306 aa)
	A0A162YDA6	Uncharacterized protein. (256 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (277 aa)
	Dcl	DsRNA-specific ribonuclease III dicer; Belongs to the helicase family. Dicer subfamily. (1568 aa)
	A0A162WKJ9	Lactamase_B domain-containing protein. (283 aa)
	A0A162V3B0	Uncharacterized protein. (311 aa)
	A0A162UJJ9	Uncharacterized protein; Belongs to the argonaute family. (840 aa)
	A0A162Q4N2	XPGI domain-containing protein. (152 aa)
	A0A162PVA1	AAA_12 domain-containing protein. (1367 aa)
	A0A162PV65	Uncharacterized protein; Belongs to the argonaute family. (842 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (375 aa)
	A0A167MDR3	Uncharacterized protein. (294 aa)
	A0A167NGS8	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (280 aa)
	A0A167PT46	RNase H domain-containing protein. (153 aa)
	A0A167MBR6	Uncharacterized protein. (157 aa)
	A0A167KYG7	Uncharacterized protein. (159 aa)
	A0A167KWY1	Uncharacterized protein. (267 aa)
	A0A167Q169	DBR1 domain-containing protein. (350 aa)
	A0A163DLU9	Uncharacterized protein. (784 aa)
	A0A163DBS7	PLD phosphodiesterase domain-containing protein. (423 aa)
	A0A163CV68	Uncharacterized protein. (298 aa)
	A0A167QMF1	XPGN domain-containing protein. (430 aa)
	A0A167QJ69	Uncharacterized protein. (813 aa)
	A0A167QH99	Uncharacterized protein. (470 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162PV65	A0A163CV68	A0A162PV65	A0A163CV68	Uncharacterized protein; Belongs to the argonaute family.	Uncharacterized protein.	0.912
A0A162PV65	Dcl	A0A162PV65	A0A162X0L5	Uncharacterized protein; Belongs to the argonaute family.	DsRNA-specific ribonuclease III dicer; Belongs to the helicase family. Dicer subfamily.	0.977
A0A162PVA1	A0A162Q4N2	A0A162PVA1	A0A162Q4N2	AAA_12 domain-containing protein.	XPGI domain-containing protein.	0.940
A0A162PVA1	A0A162V3B0	A0A162PVA1	A0A162V3B0	AAA_12 domain-containing protein.	Uncharacterized protein.	0.971
A0A162PVA1	A0A167MDR3	A0A162PVA1	A0A167MDR3	AAA_12 domain-containing protein.	Uncharacterized protein.	0.408
A0A162PVA1	A0A167QH99	A0A162PVA1	A0A167QH99	AAA_12 domain-containing protein.	Uncharacterized protein.	0.523
A0A162PVA1	A0A167QMF1	A0A162PVA1	A0A167QMF1	AAA_12 domain-containing protein.	XPGN domain-containing protein.	0.940
A0A162PVA1	FEN1	A0A162PVA1	A0A167P3U0	AAA_12 domain-containing protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.940
A0A162PVA1	SLX1	A0A162PVA1	A0A167PH33	AAA_12 domain-containing protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.815
A0A162Q4N2	A0A162PVA1	A0A162Q4N2	A0A162PVA1	XPGI domain-containing protein.	AAA_12 domain-containing protein.	0.940
A0A162Q4N2	A0A162V3B0	A0A162Q4N2	A0A162V3B0	XPGI domain-containing protein.	Uncharacterized protein.	0.798
A0A162Q4N2	A0A163BD10	A0A162Q4N2	A0A163BD10	XPGI domain-containing protein.	RNase H domain-containing protein.	0.634
A0A162Q4N2	A0A167MDR3	A0A162Q4N2	A0A167MDR3	XPGI domain-containing protein.	Uncharacterized protein.	0.450
A0A162Q4N2	A0A167NGS8	A0A162Q4N2	A0A167NGS8	XPGI domain-containing protein.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.656
A0A162Q4N2	A0A167PT46	A0A162Q4N2	A0A167PT46	XPGI domain-containing protein.	RNase H domain-containing protein.	0.634
A0A162Q4N2	SLX1	A0A162Q4N2	A0A167PH33	XPGI domain-containing protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.708
A0A162UJJ9	A0A163CV68	A0A162UJJ9	A0A163CV68	Uncharacterized protein; Belongs to the argonaute family.	Uncharacterized protein.	0.912
A0A162UJJ9	Dcl	A0A162UJJ9	A0A162X0L5	Uncharacterized protein; Belongs to the argonaute family.	DsRNA-specific ribonuclease III dicer; Belongs to the helicase family. Dicer subfamily.	0.977
A0A162V3B0	A0A162PVA1	A0A162V3B0	A0A162PVA1	Uncharacterized protein.	AAA_12 domain-containing protein.	0.971
A0A162V3B0	A0A162Q4N2	A0A162V3B0	A0A162Q4N2	Uncharacterized protein.	XPGI domain-containing protein.	0.798