(15 nodes) DNA replication preinitiation complex network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (744 aa)
	A0A162UU18	AAA_16 domain-containing protein. (501 aa)
	A0A162YFP0	Uncharacterized protein. (300 aa)
	A0A163AWG2	N-acetyltransferase domain-containing protein. (350 aa)
	A0A163BG53	DNA helicase; Belongs to the MCM family. (742 aa)
	A0A167K7U7	DNA helicase; Belongs to the MCM family. (724 aa)
	A0A167KR37	Sld5 domain-containing protein. (207 aa)
	A0A167MYD1	Uncharacterized protein. (612 aa)
	A0A167P240	DNA helicase; Belongs to the MCM family. (808 aa)
	A0A167P8K4	DNA helicase; Belongs to the MCM family. (850 aa)
	A0A167Q2C7	DNA helicase; Belongs to the MCM family. (902 aa)
	A0A167R3H1	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (485 aa)
	A0A162NB63	Sld5 domain-containing protein. (180 aa)
	A0A162TBR5	Uncharacterized protein. (369 aa)
	A0A162TJD2	ORC_WH_C domain-containing protein. (836 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162NB63	A0A162YFP0	A0A162NB63	A0A162YFP0	Sld5 domain-containing protein.	Uncharacterized protein.	0.966
A0A162NB63	A0A163BG53	A0A162NB63	A0A163BG53	Sld5 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A162NB63	A0A167K7U7	A0A162NB63	A0A167K7U7	Sld5 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A162NB63	A0A167KR37	A0A162NB63	A0A167KR37	Sld5 domain-containing protein.	Sld5 domain-containing protein.	0.999
A0A162NB63	A0A167MYD1	A0A162NB63	A0A167MYD1	Sld5 domain-containing protein.	Uncharacterized protein.	0.996
A0A162NB63	A0A167P240	A0A162NB63	A0A167P240	Sld5 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A162NB63	A0A167P8K4	A0A162NB63	A0A167P8K4	Sld5 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.992
A0A162NB63	A0A167Q2C7	A0A162NB63	A0A167Q2C7	Sld5 domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.997
A0A162NB63	A0A167R3H1	A0A162NB63	A0A167R3H1	Sld5 domain-containing protein.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.517
A0A162NB63	MCM7	A0A162NB63	A0A162UJX8	Sld5 domain-containing protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.997
A0A162TBR5	A0A162TJD2	A0A162TBR5	A0A162TJD2	Uncharacterized protein.	ORC_WH_C domain-containing protein.	0.999
A0A162TBR5	A0A162UU18	A0A162TBR5	A0A162UU18	Uncharacterized protein.	AAA_16 domain-containing protein.	0.999
A0A162TBR5	A0A163BG53	A0A162TBR5	A0A163BG53	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
A0A162TBR5	A0A167K7U7	A0A162TBR5	A0A167K7U7	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
A0A162TBR5	A0A167MYD1	A0A162TBR5	A0A167MYD1	Uncharacterized protein.	Uncharacterized protein.	0.967
A0A162TBR5	A0A167P240	A0A162TBR5	A0A167P240	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
A0A162TBR5	A0A167P8K4	A0A162TBR5	A0A167P8K4	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
A0A162TBR5	A0A167Q2C7	A0A162TBR5	A0A167Q2C7	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
A0A162TBR5	A0A167R3H1	A0A162TBR5	A0A167R3H1	Uncharacterized protein.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.999
A0A162TBR5	MCM7	A0A162TBR5	A0A162UJX8	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.998