(69 nodes) Meiotic cell cycle process network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A167PIB9	DNA_MISMATCH_REPAIR_2 domain-containing protein. (765 aa)
	A0A162U6T4	Uncharacterized protein. (853 aa)
	A0A162U643	Csm1 domain-containing protein. (289 aa)
	Plo1	Serine/threonine protein kinase. (249 aa)
	A0A162TSC1	Serine/Threonine kinase CK1; Belongs to the protein kinase superfamily. (305 aa)
	A0A162TLT1	Carbohydrate esterase family 4 protein. (394 aa)
	A0A162TGD1	Uncharacterized protein. (1515 aa)
	A0A162TEV8	Mcp5_PH domain-containing protein. (1955 aa)
	A0A162Q418	Uncharacterized protein. (620 aa)
	A0A162Q3V1	Uncharacterized protein. (267 aa)
	A0A162Q121	CRAL-TRIO domain-containing protein. (319 aa)
	A0A162PY93	Uncharacterized protein. (259 aa)
	A0A162PPA0	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (393 aa)
	A0A162PL32	Uncharacterized protein. (676 aa)
	A0A162NC51	Uncharacterized protein. (1062 aa)
	A0A162N8Y0	DNA_mis_repair domain-containing protein. (363 aa)
	A0A162N8U1	Rad51 domain-containing protein. (57 aa)
	A0A162N632	Ubiquitin-like domain-containing protein. (458 aa)
	A0A167RDZ8	Chitin deacetylase. (376 aa)
	A0A167R6G4	CCCH-type zinc finger transcription factor. (733 aa)
	A0A167QYE2	DNA_mis_repair domain-containing protein. (677 aa)
	A0A167QTH9	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (333 aa)
	A0A167QMG2	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1187 aa)
	A0A167PX39	PH domain-containing protein. (771 aa)
	A0A167P8R7	Uncharacterized protein. (809 aa)
	A0A167P8B5	Uncharacterized protein. (779 aa)
	A0A167P417	Rad51 domain-containing protein. (100 aa)
	A0A167NM89	DNA polymerase. (1151 aa)
	A0A167NFT6	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (683 aa)
	A0A167NFL0	Plus3 domain-containing protein. (536 aa)
	A0A167MPT9	Uncharacterized protein. (282 aa)
	A0A167MNC4	UmuC domain-containing protein. (609 aa)
	A0A167M9L1	MutL_C domain-containing protein. (218 aa)
	A0A167M373	PIPK domain-containing protein. (431 aa)
	A0A167LCF6	Uncharacterized protein. (580 aa)
	A0A167L9A7	Uncharacterized protein. (712 aa)
	A0A167L451	Checkpoint protein; Belongs to the HUS1 family. (271 aa)
	A0A167L178	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (601 aa)
	A0A167KYX3	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1184 aa)
	A0A167KVA2	DNA_mis_repair domain-containing protein. (687 aa)
	A0A167KNN7	Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (214 aa)
	A0A167KMD1	RING-type domain-containing protein. (260 aa)
	A0A167K307	MutL_C domain-containing protein. (759 aa)
	A0A167JNU8	Uncharacterized protein. (452 aa)
	A0A167JIV2	WD_REPEATS_REGION domain-containing protein. (323 aa)
	A0A167JHW9	ERCC4 domain-containing protein. (893 aa)
	A0A163ET51	Aldedh domain-containing protein. (590 aa)
	A0A163ERE0	PIPK domain-containing protein. (412 aa)
	A0A163ELX9	Carbohydrate esterase family 4 protein. (399 aa)
	A0A163EG91	Uncharacterized protein. (106 aa)
	A0A163E7C7	Uncharacterized protein. (1152 aa)
	A0A163D827	Uncharacterized protein. (241 aa)
	A0A163B9B4	Cnd1 domain-containing protein. (1129 aa)
	A0A163B643	Uncharacterized protein. (178 aa)
	A0A163B0P3	ERCC4 domain-containing protein. (531 aa)
	A0A163ANU3	SUN domain-containing protein. (846 aa)
	A0A162YL98	Serine/Threonine kinase CK1. (307 aa)
	A0A162YIW6	Uncharacterized protein. (172 aa)
	A0A162YCM2	AAA_23 domain-containing protein. (86 aa)
	A0A162Y3X1	PIPK domain-containing protein. (459 aa)
	A0A162WP23	Uncharacterized protein; Belongs to the MT-A70-like family. (330 aa)
	A0A162WGS2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (320 aa)
	A0A162V019	PIPK domain-containing protein. (423 aa)
	A0A162UUM4	Uncharacterized protein; Belongs to the RecA family. (356 aa)
	A0A162UPA9	Serine/Threonine kinase CK1; Belongs to the protein kinase superfamily. (303 aa)
	A0A162UN24	Serine/Threonine kinase CK1; Belongs to the protein kinase superfamily. (305 aa)
	A0A162UDA2	Uncharacterized protein. (239 aa)
	A0A162UBL3	Pex24p domain-containing protein. (324 aa)
	A0A162U8D5	Uncharacterized protein. (428 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162N632	A0A162Q418	A0A162N632	A0A162Q418	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.923
A0A162N8U1	A0A162N8Y0	A0A162N8U1	A0A162N8Y0	Rad51 domain-containing protein.	DNA_mis_repair domain-containing protein.	0.517
A0A162N8U1	A0A162NC51	A0A162N8U1	A0A162NC51	Rad51 domain-containing protein.	Uncharacterized protein.	0.984
A0A162N8U1	A0A162PL32	A0A162N8U1	A0A162PL32	Rad51 domain-containing protein.	Uncharacterized protein.	0.959
A0A162N8U1	A0A162Q3V1	A0A162N8U1	A0A162Q3V1	Rad51 domain-containing protein.	Uncharacterized protein.	0.855
A0A162N8U1	A0A162TGD1	A0A162N8U1	A0A162TGD1	Rad51 domain-containing protein.	Uncharacterized protein.	0.757
A0A162N8U1	A0A162U6T4	A0A162N8U1	A0A162U6T4	Rad51 domain-containing protein.	Uncharacterized protein.	0.643
A0A162N8U1	A0A162UDA2	A0A162N8U1	A0A162UDA2	Rad51 domain-containing protein.	Uncharacterized protein.	0.542
A0A162N8U1	A0A162UUM4	A0A162N8U1	A0A162UUM4	Rad51 domain-containing protein.	Uncharacterized protein; Belongs to the RecA family.	0.984
A0A162N8U1	A0A162YCM2	A0A162N8U1	A0A162YCM2	Rad51 domain-containing protein.	AAA_23 domain-containing protein.	0.855
A0A162N8U1	A0A162YIW6	A0A162N8U1	A0A162YIW6	Rad51 domain-containing protein.	Uncharacterized protein.	0.830
A0A162N8U1	A0A163B0P3	A0A162N8U1	A0A163B0P3	Rad51 domain-containing protein.	ERCC4 domain-containing protein.	0.968
A0A162N8U1	A0A163B9B4	A0A162N8U1	A0A163B9B4	Rad51 domain-containing protein.	Cnd1 domain-containing protein.	0.487
A0A162N8U1	A0A163D827	A0A162N8U1	A0A163D827	Rad51 domain-containing protein.	Uncharacterized protein.	0.691
A0A162N8U1	A0A167JHW9	A0A162N8U1	A0A167JHW9	Rad51 domain-containing protein.	ERCC4 domain-containing protein.	0.868
A0A162N8U1	A0A167K307	A0A162N8U1	A0A167K307	Rad51 domain-containing protein.	MutL_C domain-containing protein.	0.619
A0A162N8U1	A0A167KNN7	A0A162N8U1	A0A167KNN7	Rad51 domain-containing protein.	Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.	0.746
A0A162N8U1	A0A167KVA2	A0A162N8U1	A0A167KVA2	Rad51 domain-containing protein.	DNA_mis_repair domain-containing protein.	0.585
A0A162N8U1	A0A167KYX3	A0A162N8U1	A0A167KYX3	Rad51 domain-containing protein.	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.	0.407
A0A162N8U1	A0A167L178	A0A162N8U1	A0A167L178	Rad51 domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.982