(55 nodes) Base Excision Repair network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A162PVS3	Uncharacterized protein. (121 aa)
	A0A167LTK7	Uncharacterized protein. (189 aa)
	A0A167LLW9	Secreted cytidine and deoxycytidylate deaminase. (230 aa)
	A0A167L178	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (601 aa)
	A0A167JZ09	Uncharacterized protein. (257 aa)
	A0A167JPC0	Uncharacterized protein. (105 aa)
	A0A163ERC6	Uncharacterized protein. (302 aa)
	A0A163ELU5	Uncharacterized protein. (596 aa)
	A0A163DS74	Uncharacterized protein. (336 aa)
	A0A163DIT7	Retrotrans_gag domain-containing protein. (293 aa)
	A0A163D5P0	Histone H2B; Belongs to the histone H2B family. (125 aa)
	A0A163D2Z2	Uncharacterized protein. (273 aa)
	A0A163CSL9	CCHC-type zinc finger transcription factor. (498 aa)
	A0A163B3L4	Uncharacterized protein. (495 aa)
	A0A163AF23	Histone H2B; Belongs to the histone H2B family. (126 aa)
	A0A163AD41	Uncharacterized protein. (266 aa)
	A0A162ZRD6	Uncharacterized protein. (179 aa)
	A0A162ZDI4	PARP-type domain-containing protein. (235 aa)
	A0A162Y9L4	Uncharacterized protein. (111 aa)
	A0A162Y728	Uncharacterized protein. (389 aa)
	A0A162XGQ2	Vezatin domain-containing protein. (595 aa)
	A0A162XBY4	Uncharacterized protein. (757 aa)
	A0A162WLU0	Histone H2B; Belongs to the histone H2B family. (126 aa)
	A0A162WLG4	CCHC-type zinc finger transcription factor. (437 aa)
	A0A162WDF7	Uncharacterized protein. (270 aa)
	A0A162W790	Uncharacterized protein. (93 aa)
	A0A162UE24	Uncharacterized protein. (329 aa)
	A0A162U9H3	Uncharacterized protein. (422 aa)
	A0A162U8K9	Uncharacterized protein. (2508 aa)
	A0A162U6J5	AAA domain-containing protein. (749 aa)
	A0A162TQ79	Uncharacterized protein. (219 aa)
	A0A162THI0	Transcription factor TFIID, C-terminal. (364 aa)
	A0A162TCK3	Uncharacterized protein. (104 aa)
	A0A162T9K4	Uncharacterized protein. (81 aa)
	A0A162Q5T4	Uncharacterized protein. (503 aa)
	A0A162Q4N2	XPGI domain-containing protein. (152 aa)
	UNG1	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (224 aa)
	A0A167LV55	Uncharacterized protein. (517 aa)
	A0A162PQJ9	Retrotrans_gag domain-containing protein. (169 aa)
	A0A162PNP4	Integrase catalytic domain-containing protein. (51 aa)
	A0A162PLZ4	UDG domain-containing protein. (201 aa)
	A0A162NJ17	Zds_C domain-containing protein. (592 aa)
	A0A162NII1	TPR_REGION domain-containing protein. (418 aa)
	A0A162NCC9	Histone H2B; Belongs to the histone H2B family. (148 aa)
	A0A162NBQ7	Transcription factor CBF. (89 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (319 aa)
	A0A167QMF1	XPGN domain-containing protein. (430 aa)
	A0A167Q3Z7	Uncharacterized protein. (202 aa)
	A0A167PRE9	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (411 aa)
	A0A167NI84	Uncharacterized protein. (269 aa)
	A0A167NA25	Poly [ADP-ribose] polymerase. (97 aa)
	A0A167N2Q8	Uncharacterized protein. (411 aa)
	A0A167M6Z9	Uncharacterized protein. (103 aa)
	A0A167M6F6	Uncharacterized protein. (177 aa)
	A0A167LYT8	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (319 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162NCC9	A0A162ZDI4	A0A162NCC9	A0A162ZDI4	Histone H2B; Belongs to the histone H2B family.	PARP-type domain-containing protein.	0.482
A0A162NCC9	A0A167L178	A0A162NCC9	A0A167L178	Histone H2B; Belongs to the histone H2B family.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.427
A0A162NCC9	A0A167LV55	A0A162NCC9	A0A167LV55	Histone H2B; Belongs to the histone H2B family.	Uncharacterized protein.	0.724
A0A162NCC9	A0A167NA25	A0A162NCC9	A0A167NA25	Histone H2B; Belongs to the histone H2B family.	Poly [ADP-ribose] polymerase.	0.550
A0A162NII1	A0A167L178	A0A162NII1	A0A167L178	TPR_REGION domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.602
A0A162NJ17	A0A167L178	A0A162NJ17	A0A167L178	Zds_C domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.602
A0A162PLZ4	A0A162THI0	A0A162PLZ4	A0A162THI0	UDG domain-containing protein.	Transcription factor TFIID, C-terminal.	0.446
A0A162PLZ4	A0A167LYT8	A0A162PLZ4	A0A167LYT8	UDG domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.801
A0A162PLZ4	A0A167PRE9	A0A162PLZ4	A0A167PRE9	UDG domain-containing protein.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.801
A0A162PLZ4	NTH1	A0A162PLZ4	A0A167R1T7	UDG domain-containing protein.	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.467
A0A162PLZ4	UNG1	A0A162PLZ4	A0A162Q1V3	UDG domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.467
A0A162PNP4	A0A167L178	A0A162PNP4	A0A167L178	Integrase catalytic domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.602
A0A162PQJ9	A0A167L178	A0A162PQJ9	A0A167L178	Retrotrans_gag domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.602
A0A162PVS3	A0A167L178	A0A162PVS3	A0A167L178	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.602
A0A162Q4N2	A0A162Q5T4	A0A162Q4N2	A0A162Q5T4	XPGI domain-containing protein.	Uncharacterized protein.	0.873
A0A162Q4N2	A0A162THI0	A0A162Q4N2	A0A162THI0	XPGI domain-containing protein.	Transcription factor TFIID, C-terminal.	0.473
A0A162Q4N2	A0A162U6J5	A0A162Q4N2	A0A162U6J5	XPGI domain-containing protein.	AAA domain-containing protein.	0.832
A0A162Q4N2	A0A162U9H3	A0A162Q4N2	A0A162U9H3	XPGI domain-containing protein.	Uncharacterized protein.	0.530
A0A162Q4N2	A0A162XBY4	A0A162Q4N2	A0A162XBY4	XPGI domain-containing protein.	Uncharacterized protein.	0.832
A0A162Q4N2	A0A162XGQ2	A0A162Q4N2	A0A162XGQ2	XPGI domain-containing protein.	Vezatin domain-containing protein.	0.942