(24 nodes) VLDLR internalisation and degradation network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	A0A167MLT6	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (436 aa)
	A0A167R130	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
	A0A167R2X0	Ubiquitin-like domain-containing protein. (155 aa)
	A0A167R469	Uncharacterized protein. (426 aa)
	A0A167R498	Uncharacterized protein; Belongs to the peptidase S8 family. (344 aa)
	A0A167R6J7	Uncharacterized protein. (533 aa)
	A0A167RD89	Ubiquitin-like domain-containing protein. (155 aa)
	A0A162N642	KxDL domain-containing protein. (111 aa)
	A0A162Q7N6	Uncharacterized protein. (419 aa)
	A0A162TTM6	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (932 aa)
	A0A162U927	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1646 aa)
	A0A162Y7J5	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (248 aa)
	A0A162YHV0	Uncharacterized protein. (340 aa)
	A0A163D8W2	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (284 aa)
	A0A163DBP8	Uncharacterized protein; Belongs to the peptidase S8 family. (385 aa)
	A0A163ECF5	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (216 aa)
	A0A167JTY9	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
	A0A167KJS4	Ubiquitin-like domain-containing protein. (153 aa)
	A0A167KWM3	Uncharacterized protein. (222 aa)
	A0A167KX02	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (642 aa)
	A0A167LPK7	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (152 aa)
	A0A167M294	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (721 aa)
	A0A167MAX9	Uncharacterized protein; Belongs to the peptidase S8 family. (442 aa)
	A0A167MWD8	Secreted subtilisin-like serine protease; Belongs to the peptidase S8 family. (422 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A162N642	A0A167KJS4	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.707
A0A162N642	A0A167KWM3	KxDL domain-containing protein.	Uncharacterized protein.	0.692
A0A162N642	A0A167R2X0	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.707
A0A162N642	A0A167R6J7	KxDL domain-containing protein.	Uncharacterized protein.	0.692
A0A162N642	A0A167RD89	KxDL domain-containing protein.	Ubiquitin-like domain-containing protein.	0.707
A0A162TTM6	A0A162U927	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.893
A0A162TTM6	A0A167JTY9	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.916
A0A162TTM6	A0A167KJS4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Ubiquitin-like domain-containing protein.	0.696
A0A162TTM6	A0A167KWM3	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.701
A0A162TTM6	A0A167KX02	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.970
A0A162TTM6	A0A167LPK7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.992
A0A162TTM6	A0A167M294	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.970
A0A162TTM6	A0A167MLT6	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.992
A0A162TTM6	A0A167R130	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.893
A0A162TTM6	A0A167R2X0	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Ubiquitin-like domain-containing protein.	0.696
A0A162TTM6	A0A167R6J7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.701
A0A162TTM6	A0A167RD89	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Ubiquitin-like domain-containing protein.	0.696
A0A162U927	A0A162TTM6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.893
A0A162U927	A0A167JTY9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.989
A0A162U927	A0A167KJS4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Ubiquitin-like domain-containing protein.	0.665