(67 nodes) Pyruvate metabolism network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A162YDE6	Uncharacterized protein. (519 aa)
	A0A162NIP8	Lactamase_B domain-containing protein. (257 aa)
	PbMdha	Malate dehydrogenase. (331 aa)
	A0A162PME0	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (414 aa)
	A0A162PUR4	Uncharacterized protein. (625 aa)
	A0A162PUS5	Pyruvate carboxyltransferase domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (413 aa)
	A0A162PVF9	Lactamase_B domain-containing protein. (305 aa)
	A0A162PYK7	Uncharacterized protein. (438 aa)
	A0A162Q1S0	FAD-binding PCMH-type domain-containing protein. (541 aa)
	A0A162Q478	Malate synthase; Belongs to the malate synthase family. (544 aa)
	PbPdhE1b	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (373 aa)
	A0A162U6M6	Uncharacterized protein. (452 aa)
	A0A162UA04	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (141 aa)
	A0A162UAE2	Pyruvate kinase; Belongs to the pyruvate kinase family. (492 aa)
	A0A162UB76	Lactamase_B domain-containing protein. (245 aa)
	A0A162UBJ6	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (473 aa)
	A0A162UIK2	Pyruvate carboxyltransferase domain-containing protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (452 aa)
	A0A162UNT2	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (355 aa)
	A0A162URL9	Malate synthase; Belongs to the malate synthase family. (544 aa)
	A0A162UTR4	Uncharacterized protein. (2221 aa)
	A0A162V4Q6	Malic enzyme. (603 aa)
	PbPdhE2	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (446 aa)
	A0A162YIU7	FAD-binding PCMH-type domain-containing protein. (543 aa)
	A0A163AEZ7	Uncharacterized protein. (553 aa)
	A0A163B987	Uncharacterized protein. (836 aa)
	A0A163BA77	FAD-binding PCMH-type domain-containing protein. (532 aa)
	A0A163CUP1	PDH complex E3BP. (207 aa)
	A0A163CYM8	AcetylCoA_hyd_C domain-containing protein. (523 aa)
	PbPdhE1a	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (370 aa)
	A0A163D4D9	DUF663 domain-containing protein. (160 aa)
	A0A163DC70	Lactamase_B domain-containing protein. (251 aa)
	A0A163DU96	AB hydrolase-1 domain-containing protein. (480 aa)
	PbMdhb	Malate dehydrogenase. (337 aa)
	A0A163E8R0	Uncharacterized protein. (701 aa)
	A0A163EMM9	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (163 aa)
	A0A167JJQ1	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
	A0A167K5Y6	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (496 aa)
	A0A167KQN5	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1175 aa)
	A0A167KR82	Uncharacterized protein. (481 aa)
	A0A167KXZ2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	A0A167KZF1	Malic enzyme. (591 aa)
	A0A167L069	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (474 aa)
	A0A167L0T9	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1171 aa)
	A0A167LAQ6	Malic enzyme. (634 aa)
	A0A167LKS1	AcetylCoA_hyd_C domain-containing protein. (523 aa)
	A0A167LU12	Ldh_1_N domain-containing protein. (288 aa)
	leuA	Alpha-isopropylmalate synthase. (555 aa)
	A0A167M7S9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
	A0A167MQL8	Uncharacterized protein. (560 aa)
	A0A167MY15	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	PbFumHa	Fumarate hydratase. (491 aa)
	A0A167NRS6	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (546 aa)
	PbFumHb	Fumarate hydratase. (466 aa)
	A0A167NWP3	Uncharacterized protein. (553 aa)
	A0A167P046	Uncharacterized protein. (243 aa)
	A0A167P0C8	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (326 aa)
	A0A167P849	Lactamase_B domain-containing protein. (258 aa)
	A0A167PA28	Uncharacterized protein. (373 aa)
	A0A167PBU9	Uncharacterized protein. (317 aa)
	A0A167PQ51	Uncharacterized protein; Belongs to the cytochrome b5 family. (486 aa)
	A0A167PXH6	Malic enzyme. (627 aa)
	A0A167Q0H3	Pyruvate kinase; Belongs to the pyruvate kinase family. (533 aa)
	NDE2	Dihydrolipoyl dehydrogenase. (508 aa)
	A0A167QIG6	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (494 aa)
	A0A167QWW6	Uncharacterized protein. (432 aa)
	A0A167R2V5	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (431 aa)
	A0A167R5F4	Uncharacterized protein; Belongs to the LDH/MDH superfamily. (303 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162NIP8	A0A162Q1S0	A0A162NIP8	A0A162Q1S0	Lactamase_B domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.678
A0A162NIP8	A0A162UA04	A0A162NIP8	A0A162UA04	Lactamase_B domain-containing protein.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.740
A0A162NIP8	A0A162YIU7	A0A162NIP8	A0A162YIU7	Lactamase_B domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.678
A0A162NIP8	A0A163BA77	A0A162NIP8	A0A163BA77	Lactamase_B domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.618
A0A162NIP8	A0A163EMM9	A0A162NIP8	A0A163EMM9	Lactamase_B domain-containing protein.	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.	0.759
A0A162NIP8	A0A167JJQ1	A0A162NIP8	A0A167JJQ1	Lactamase_B domain-containing protein.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.583
A0A162NIP8	A0A167P046	A0A162NIP8	A0A167P046	Lactamase_B domain-containing protein.	Uncharacterized protein.	0.688
A0A162NIP8	A0A167P0C8	A0A162NIP8	A0A167P0C8	Lactamase_B domain-containing protein.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.583
A0A162NIP8	A0A167PQ51	A0A162NIP8	A0A167PQ51	Lactamase_B domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.571
A0A162PME0	A0A163AEZ7	A0A162PME0	A0A163AEZ7	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.433
A0A162PME0	A0A167MQL8	A0A162PME0	A0A167MQL8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.433
A0A162PME0	A0A167NWP3	A0A162PME0	A0A167NWP3	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.433
A0A162PUR4	A0A162PYK7	A0A162PUR4	A0A162PYK7	Uncharacterized protein.	Uncharacterized protein.	0.592
A0A162PUR4	A0A162UA04	A0A162PUR4	A0A162UA04	Uncharacterized protein.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.758
A0A162PUR4	A0A162UAE2	A0A162PUR4	A0A162UAE2	Uncharacterized protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.681
A0A162PUR4	A0A162UNT2	A0A162PUR4	A0A162UNT2	Uncharacterized protein.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.746
A0A162PUR4	A0A162V4Q6	A0A162PUR4	A0A162V4Q6	Uncharacterized protein.	Malic enzyme.	0.682
A0A162PUR4	A0A163AEZ7	A0A162PUR4	A0A163AEZ7	Uncharacterized protein.	Uncharacterized protein.	0.668
A0A162PUR4	A0A167KQN5	A0A162PUR4	A0A167KQN5	Uncharacterized protein.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.729
A0A162PUR4	A0A167KZF1	A0A162PUR4	A0A167KZF1	Uncharacterized protein.	Malic enzyme.	0.682