(76 nodes) DNA replication network (Phycomyces blakesleeanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A162PQJ9	Retrotrans_gag domain-containing protein. (169 aa)
	A0A163BD10	RNase H domain-containing protein. (369 aa)
	A0A163B3L4	Uncharacterized protein. (495 aa)
	A0A163AD41	Uncharacterized protein. (266 aa)
	A0A162ZWE1	AAA domain-containing protein. (337 aa)
	A0A162ZRQ3	Uncharacterized protein. (142 aa)
	A0A162ZRD6	Uncharacterized protein. (179 aa)
	A0A162ZIE5	Uncharacterized protein. (266 aa)
	A0A162Y9L4	Uncharacterized protein. (111 aa)
	A0A162XIN6	Uncharacterized protein. (264 aa)
	A0A162XGQ2	Vezatin domain-containing protein. (595 aa)
	A0A162XBY4	Uncharacterized protein. (757 aa)
	A0A162WLG4	CCHC-type zinc finger transcription factor. (437 aa)
	A0A162WDF7	Uncharacterized protein. (270 aa)
	A0A162W790	Uncharacterized protein. (93 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (744 aa)
	A0A162UGC7	DNA polymerase. (828 aa)
	A0A162UE24	Uncharacterized protein. (329 aa)
	A0A162U9H3	Uncharacterized protein. (422 aa)
	A0A162U944	DNA ligase. (639 aa)
	A0A162U8Y9	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (425 aa)
	A0A162U6J5	AAA domain-containing protein. (749 aa)
	A0A162TTU4	Uncharacterized protein. (314 aa)
	A0A162TCK3	Uncharacterized protein. (104 aa)
	A0A162T9K4	Uncharacterized protein. (81 aa)
	A0A162Q4N2	XPGI domain-containing protein. (152 aa)
	A0A162Q3Y5	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (183 aa)
	A0A162PVS3	Uncharacterized protein. (121 aa)
	A0A162PVA1	AAA_12 domain-containing protein. (1367 aa)
	A0A162PNP4	Integrase catalytic domain-containing protein. (51 aa)
	A0A162NJ17	Zds_C domain-containing protein. (592 aa)
	A0A162NII1	TPR_REGION domain-containing protein. (418 aa)
	A0A162NDE4	Uncharacterized protein. (249 aa)
	A0A162NBQ7	Transcription factor CBF. (89 aa)
	A0A162N877	Exo84_C domain-containing protein. (566 aa)
	A0A162N615	AAA domain-containing protein. (335 aa)
	A0A167PQC9	AAA domain-containing protein. (407 aa)
	A0A167PC19	Vezatin domain-containing protein. (595 aa)
	A0A167P8K4	DNA helicase; Belongs to the MCM family. (850 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (375 aa)
	A0A167P240	DNA helicase; Belongs to the MCM family. (808 aa)
	A0A167NM89	DNA polymerase. (1151 aa)
	A0A167NI84	Uncharacterized protein. (269 aa)
	A0A167NGS8	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (280 aa)
	A0A167N2Q8	Uncharacterized protein. (411 aa)
	A0A167MMI3	AAA domain-containing protein. (571 aa)
	A0A167MI72	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2213 aa)
	A0A167MDR3	Uncharacterized protein. (294 aa)
	A0A167M6Z9	Uncharacterized protein. (103 aa)
	A0A167M6F6	Uncharacterized protein. (177 aa)
	A0A167LTK7	Uncharacterized protein. (189 aa)
	A0A167L178	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (601 aa)
	A0A167KUM1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
	A0A167KHZ5	Uncharacterized protein. (430 aa)
	A0A167KG19	AAA domain-containing protein. (357 aa)
	A0A167K7U7	DNA helicase; Belongs to the MCM family. (724 aa)
	A0A167JZ09	Uncharacterized protein. (257 aa)
	A0A167JTM5	Uncharacterized protein. (507 aa)
	A0A167JPC0	Uncharacterized protein. (105 aa)
	A0A167JD07	Uncharacterized protein. (349 aa)
	A0A163ERC6	Uncharacterized protein. (302 aa)
	A0A163ELU5	Uncharacterized protein. (596 aa)
	A0A163DVH2	BRCT domain-containing protein. (702 aa)
	A0A163DS74	Uncharacterized protein. (336 aa)
	A0A163DIT7	Retrotrans_gag domain-containing protein. (293 aa)
	A0A163D2Z2	Uncharacterized protein. (273 aa)
	A0A163D1U8	DNA polymerase. (1072 aa)
	A0A163CSL9	CCHC-type zinc finger transcription factor. (498 aa)
	A0A163BG53	DNA helicase; Belongs to the MCM family. (742 aa)
	A0A167R7K1	DNA_pol_E_B domain-containing protein. (438 aa)
	A0A167R3V1	DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (495 aa)
	A0A167QMF1	XPGN domain-containing protein. (430 aa)
	A0A167Q6I3	Macro domain-containing protein. (213 aa)
	A0A167Q3Z7	Uncharacterized protein. (202 aa)
	A0A167Q2C7	DNA helicase; Belongs to the MCM family. (902 aa)
	A0A167PT46	RNase H domain-containing protein. (153 aa)

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162N615	A0A162NDE4	A0A162N615	A0A162NDE4	AAA domain-containing protein.	Uncharacterized protein.	0.955
A0A162N615	A0A162PVA1	A0A162N615	A0A162PVA1	AAA domain-containing protein.	AAA_12 domain-containing protein.	0.733
A0A162N615	A0A162Q4N2	A0A162N615	A0A162Q4N2	AAA domain-containing protein.	XPGI domain-containing protein.	0.876
A0A162N615	A0A162TTU4	A0A162N615	A0A162TTU4	AAA domain-containing protein.	Uncharacterized protein.	0.880
A0A162N615	A0A162U6J5	A0A162N615	A0A162U6J5	AAA domain-containing protein.	AAA domain-containing protein.	0.973
A0A162N615	A0A162U8Y9	A0A162N615	A0A162U8Y9	AAA domain-containing protein.	DNA primase; Belongs to the eukaryotic-type primase small subunit family.	0.900
A0A162N615	A0A162U944	A0A162N615	A0A162U944	AAA domain-containing protein.	DNA ligase.	0.867
A0A162N615	A0A162U9H3	A0A162N615	A0A162U9H3	AAA domain-containing protein.	Uncharacterized protein.	0.709
A0A162N615	A0A162UGC7	A0A162N615	A0A162UGC7	AAA domain-containing protein.	DNA polymerase.	0.832
A0A162N615	A0A162XBY4	A0A162N615	A0A162XBY4	AAA domain-containing protein.	Uncharacterized protein.	0.973
A0A162N615	A0A162XGQ2	A0A162N615	A0A162XGQ2	AAA domain-containing protein.	Vezatin domain-containing protein.	0.979
A0A162N615	A0A162ZWE1	A0A162N615	A0A162ZWE1	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A162N615	A0A163BD10	A0A162N615	A0A163BD10	AAA domain-containing protein.	RNase H domain-containing protein.	0.614
A0A162N615	A0A163BG53	A0A162N615	A0A163BG53	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.767
A0A162N615	A0A163D1U8	A0A162N615	A0A163D1U8	AAA domain-containing protein.	DNA polymerase.	0.884
A0A162N615	A0A163DVH2	A0A162N615	A0A163DVH2	AAA domain-containing protein.	BRCT domain-containing protein.	0.982
A0A162N615	A0A167JD07	A0A162N615	A0A167JD07	AAA domain-containing protein.	Uncharacterized protein.	0.999
A0A162N615	A0A167K7U7	A0A162N615	A0A167K7U7	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.736
A0A162N615	A0A167KG19	A0A162N615	A0A167KG19	AAA domain-containing protein.	AAA domain-containing protein.	0.999
A0A162N615	A0A167KHZ5	A0A162N615	A0A167KHZ5	AAA domain-containing protein.	Uncharacterized protein.	0.838