(50 nodes) Sterol biosynthetic process network (Piloderma croceum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A0C3FCU4	Glycosyltransferase family 1 protein. (1058 aa)
	A0A0C3GL11	Uncharacterized protein. (248 aa)
	A0A0C3GIU1	SAM_MT_ERG6_SMT domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. (351 aa)
	A0A0C3GIF8	Uncharacterized protein. (480 aa)
	A0A0C3GGP5	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (252 aa)
	A0A0C3GEA4	Uncharacterized protein. (114 aa)
	A0A0C3G9Q6	Glycosyltransferase family 1 protein. (657 aa)
	A0A0C3G502	Uncharacterized protein. (636 aa)
	A0A0C3G4Y6	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1274 aa)
	A0A0C3G460	Sterol 3-beta-glucosyltransferase; Belongs to the glycosyltransferase 28 family. (1482 aa)
	A0A0C3G3R6	Uncharacterized protein. (608 aa)
	A0A0C3FYP2	Peptidase_S9 domain-containing protein. (291 aa)
	A0A0C3FXR5	Uncharacterized protein; Belongs to the cytochrome P450 family. (549 aa)
	A0A0C3FV65	Uncharacterized protein; Belongs to the cytochrome P450 family. (456 aa)
	A0A0C3FUT3	S5A_REDUCTASE domain-containing protein. (265 aa)
	A0A0C3FR81	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (240 aa)
	A0A0C3FNX8	GHMP_kinases_N domain-containing protein. (151 aa)
	A0A0C3FLI2	Uncharacterized protein. (142 aa)
	A0A0C3FKT6	Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa)
	A0A0C3FHQ5	Uncharacterized protein. (418 aa)
	A0A0C3FEW0	Uncharacterized protein. (432 aa)
	A0A0C3F7Y4	Uncharacterized protein; Belongs to the cytochrome P450 family. (507 aa)
	A0A0C3EZH3	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (353 aa)
	A0A0C3EUD0	MDD_C domain-containing protein. (165 aa)
	A0A0C3ETT7	MDD_C domain-containing protein. (110 aa)
	A0A0C3EQX6	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (132 aa)
	A0A0C3CQB7	Uncharacterized protein. (352 aa)
	A0A0C3CLW8	FAD-binding FR-type domain-containing protein. (358 aa)
	A0A0C3CL80	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (473 aa)
	A0A0C3CKD4	SE domain-containing protein. (481 aa)
	A0A0C3CK33	Uncharacterized protein. (497 aa)
	A0A0C3CHK6	3Beta_HSD domain-containing protein. (439 aa)
	A0A0C3CGE1	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (332 aa)
	A0A0C3BZ61	Uncharacterized protein. (136 aa)
	A0A0C3BVZ9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	A0A0C3BVT9	Uncharacterized protein. (352 aa)
	A0A0C3BUF2	MDD_C domain-containing protein. (151 aa)
	A0A0C3BRZ7	Glycosyltransferase family 1 protein. (1076 aa)
	A0A0C3BPX1	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (254 aa)
	A0A0C3BMS4	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (334 aa)
	A0A0C3BJP5	Uncharacterized protein; Belongs to the cytochrome P450 family. (370 aa)
	A0A0C3BHD4	Uncharacterized protein. (629 aa)
	A0A0C3BD37	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (341 aa)
	A0A0C3B4S3	Uncharacterized protein. (287 aa)
	A0A0C3B4J2	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (404 aa)
	A0A0C3B439	GHMP_kinases_N domain-containing protein. (141 aa)
	A0A0C3B159	Uncharacterized protein; Belongs to the cytochrome P450 family. (516 aa)
	A0A0C3AX06	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (732 aa)
	A0A0C3AIH5	Uncharacterized protein; Belongs to the cytochrome P450 family. (497 aa)
	A0A0C3AD97	Glycosyltransferase family 1 protein. (154 aa)

Your Current Organism:

Piloderma croceum

NCBI taxonomy Id: 765440
Other names: P. croceum F 1598, Piloderma croceum F 1598

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0C3AD97	A0A0C3CHK6	Glycosyltransferase family 1 protein.	3Beta_HSD domain-containing protein.	0.452
A0A0C3AD97	A0A0C3FHQ5	Glycosyltransferase family 1 protein.	Uncharacterized protein.	0.456
A0A0C3AIH5	A0A0C3AX06	Uncharacterized protein; Belongs to the cytochrome P450 family.	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.417
A0A0C3AIH5	A0A0C3B439	Uncharacterized protein; Belongs to the cytochrome P450 family.	GHMP_kinases_N domain-containing protein.	0.409
A0A0C3AIH5	A0A0C3B4J2	Uncharacterized protein; Belongs to the cytochrome P450 family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.409
A0A0C3AIH5	A0A0C3BD37	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.817
A0A0C3AIH5	A0A0C3BHD4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.488
A0A0C3AIH5	A0A0C3BMS4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.943
A0A0C3AIH5	A0A0C3BPX1	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.943
A0A0C3AIH5	A0A0C3BUF2	Uncharacterized protein; Belongs to the cytochrome P450 family.	MDD_C domain-containing protein.	0.409
A0A0C3AIH5	A0A0C3BVZ9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.442
A0A0C3AIH5	A0A0C3CHK6	Uncharacterized protein; Belongs to the cytochrome P450 family.	3Beta_HSD domain-containing protein.	0.913
A0A0C3AIH5	A0A0C3CK33	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.894
A0A0C3AIH5	A0A0C3CKD4	Uncharacterized protein; Belongs to the cytochrome P450 family.	SE domain-containing protein.	0.776
A0A0C3AIH5	A0A0C3CL80	Uncharacterized protein; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.733
A0A0C3AIH5	A0A0C3EQX6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.494
A0A0C3AIH5	A0A0C3ETT7	Uncharacterized protein; Belongs to the cytochrome P450 family.	MDD_C domain-containing protein.	0.409
A0A0C3AIH5	A0A0C3EUD0	Uncharacterized protein; Belongs to the cytochrome P450 family.	MDD_C domain-containing protein.	0.409
A0A0C3AIH5	A0A0C3EZH3	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.861
A0A0C3AIH5	A0A0C3FEW0	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.939