(45 nodes) RNA polymerase II, holoenzyme network (Pyrenochaeta sp. DS3sAY3a)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A178EFU0	TFIID-31kDa-domain-containing protein. (263 aa)
	A0A178EFX0	Uncharacterized protein. (472 aa)
	A0A178EFY0	Uncharacterized protein. (418 aa)
	A0A178EG17	Transcription initiation factor TFIID subunit 5. (732 aa)
	A0A178EGV5	Uncharacterized protein. (709 aa)
	A0A178EI97	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (462 aa)
	A0A178EIL8	Transcription initiation factor IIF. (352 aa)
	A0A178DZE3	Serine/threonine-protein kinase-like protein; Belongs to the protein kinase superfamily. (440 aa)
	A0A178DYC8	HTH TFE/IIEalpha-type domain-containing protein. (410 aa)
	A0A178DXY8	CDC73-domain-containing protein. (421 aa)
	A0A178DXR3	TFIID-18kDa-domain-containing protein. (175 aa)
	A0A178DWT1	Uncharacterized protein. (378 aa)
	A0A178DWP0	Kinase-like protein. (502 aa)
	A0A178DTT8	Uncharacterized protein. (248 aa)
	A0A178DTM9	WD40 repeat-like protein. (317 aa)
	A0A178DTD2	DUF4211 domain-containing protein. (687 aa)
	A0A178DTA4	TFIIH basal transcription factor complex helicase XPB subunit. (802 aa)
	A0A178DSG4	DUF3591 domain-containing protein. (1112 aa)
	A0A178DQT2	Kinase-like protein. (968 aa)
	A0A178DM54	Uncharacterized protein. (1470 aa)
	A0A178DKT5	Chromatin associated protein KTI12. (296 aa)
	A0A178EIX2	TAFII55_N domain-containing protein. (556 aa)
	A0A178EK15	BTP domain-containing protein. (255 aa)
	A0A178E463	Transcription factor Tfb4. (377 aa)
	A0A178E4A7	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (222 aa)
	A0A178E5D6	Protein prenylyltransferase. (1177 aa)
	A0A178E5H2	Cyclin-like protein. (413 aa)
	A0A178E6F0	Uncharacterized protein. (452 aa)
	A0A178E8E8	Uncharacterized protein. (419 aa)
	A0A178E8Q5	Plus-3-domain-containing protein. (522 aa)
	A0A178EA25	Uncharacterized protein. (343 aa)
	A0A178EAK3	TAFII28 domain-containing protein. (341 aa)
	A0A178EBI5	RBP11-like subunits of RNA polymerase. (176 aa)
	A0A178EDB3	Uncharacterized protein. (72 aa)
	A0A178E0X6	Uncharacterized protein. (567 aa)
	A0A178E156	Uncharacterized protein. (719 aa)
	A0A178E281	Paf1-domain-containing protein. (450 aa)
	A0A178E2A6	Insert subdomain of RNA polymerase alpha subunit. (329 aa)
	A0A178E2H2	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (491 aa)
	A0A178E3W1	Uncharacterized protein. (313 aa)
	A0A178EDT1	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (263 aa)
	A0A178EE86	RNA polymerase II transcription factor-like protein. (651 aa)
	A0A178EEF0	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (112 aa)
	A0A178EFG4	CDK-activating kinase assembly factor. (305 aa)
	A0A178EFJ7	Transcription factor IIA, alpha/beta subunit. (375 aa)

Your Current Organism:

Pyrenochaeta sp. DS3sAY3a

NCBI taxonomy Id: 765867
Other names: P. sp. DS3sAY3a

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A178DM54	A0A178DQT2	Uncharacterized protein.	Kinase-like protein.	0.791
A0A178DM54	A0A178DSG4	Uncharacterized protein.	DUF3591 domain-containing protein.	0.999
A0A178DM54	A0A178DTA4	Uncharacterized protein.	TFIIH basal transcription factor complex helicase XPB subunit.	0.892
A0A178DM54	A0A178DTD2	Uncharacterized protein.	DUF4211 domain-containing protein.	0.976
A0A178DM54	A0A178DWP0	Uncharacterized protein.	Kinase-like protein.	0.791
A0A178DM54	A0A178DWT1	Uncharacterized protein.	Uncharacterized protein.	0.976
A0A178DM54	A0A178DXR3	Uncharacterized protein.	TFIID-18kDa-domain-containing protein.	0.999
A0A178DM54	A0A178DYC8	Uncharacterized protein.	HTH TFE/IIEalpha-type domain-containing protein.	0.903
A0A178DM54	A0A178DZE3	Uncharacterized protein.	Serine/threonine-protein kinase-like protein; Belongs to the protein kinase superfamily.	0.864
A0A178DM54	A0A178E156	Uncharacterized protein.	Uncharacterized protein.	0.964
A0A178DM54	A0A178E2A6	Uncharacterized protein.	Insert subdomain of RNA polymerase alpha subunit.	0.930
A0A178DM54	A0A178E2H2	Uncharacterized protein.	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.884
A0A178DM54	A0A178E3W1	Uncharacterized protein.	Uncharacterized protein.	0.862
A0A178DM54	A0A178E463	Uncharacterized protein.	Transcription factor Tfb4.	0.966
A0A178DM54	A0A178E4A7	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.999
A0A178DM54	A0A178E5H2	Uncharacterized protein.	Cyclin-like protein.	0.899
A0A178DM54	A0A178EA25	Uncharacterized protein.	Uncharacterized protein.	0.992
A0A178DM54	A0A178EAK3	Uncharacterized protein.	TAFII28 domain-containing protein.	0.984
A0A178DM54	A0A178EBI5	Uncharacterized protein.	RBP11-like subunits of RNA polymerase.	0.864
A0A178DM54	A0A178EDT1	Uncharacterized protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.901