(21 nodes) Prosthetic group metabolic process, and Thiamine diphosphate metabolic process network (Roseateles depolymerans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ALV06085.1	Hypothetical protein. (253 aa)
	ALV06146.1	Thiamine biosynthesis protein ThiS. (89 aa)
	ALV04735.1	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein. (285 aa)
	ALV04736.1	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (222 aa)
	ALV04737.1	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter. (244 aa)
	ALV06850.1	Molybdenum cofactor cytidylyltransferase; Pfam:pfam12804 MobA-like NTP transferase domain. (222 aa)
	ALV07180.1	Pfam:pfam02391 MoaE protein. (160 aa)
	ALV07290.1	Molybdenum cofactor biosynthesis protein MogA; Pfam:pfam00994 Probable molybdopterin binding domain. (196 aa)
	ALV07489.1	Molybdopterin converting factor, small subunit; Pfam:pfam02597 ThiS family. (83 aa)
	ALV07490.1	Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (416 aa)
	moaA	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (390 aa)
	mobA	Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (242 aa)
	ALV08252.1	Molybdopterin biosynthesis protein MoeB; Pfam:pfam00899 ThiF family. (254 aa)
	ALV08526.1	Hypothetical protein; Pfam:pfam13531 Bacterial extracellular solute-binding protein. (257 aa)
	ALV08581.1	Pfam:pfam08543 Phosphomethylpyrimidine kinase. (320 aa)
	thiC	Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (643 aa)
	ALV08805.1	Pfam:pfam01266 FAD dependent oxidoreductase. (365 aa)
	ALV08806.1	Sulfur transfer protein; Pfam:pfam02597 ThiS family. (74 aa)
	thiG	Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (280 aa)
	ALV08808.1	Phosphomethylpyrimidine kinase / thiamine-phosphate pyrophosphorylase; Pfam:pfam08543 Phosphomethylpyrimidine kinase. (548 aa)
	moaC	Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (160 aa)

Your Current Organism:

Roseateles depolymerans

NCBI taxonomy Id: 76731
Other names: CCUG 52219, DSM 11813, R. depolymerans, proteobacterium DSM11813, proteobacterium DSM11814, strain 61A

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALV04735.1	ALV04736.1	RD2015_231	RD2015_232	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	0.998
ALV04735.1	ALV04737.1	RD2015_231	RD2015_233	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter.	0.978
ALV04735.1	ALV07180.1	RD2015_231	RD2015_2715	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Pfam:pfam02391 MoaE protein.	0.489
ALV04735.1	ALV07290.1	RD2015_231	RD2015_2825	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Molybdenum cofactor biosynthesis protein MogA; Pfam:pfam00994 Probable molybdopterin binding domain.	0.691
ALV04735.1	ALV07490.1	RD2015_231	RD2015_3029	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.763
ALV04735.1	ALV08526.1	RD2015_231	RD2015_4077	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Hypothetical protein; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	0.900
ALV04735.1	moaA	RD2015_231	RD2015_3437	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.770
ALV04735.1	moaC	RD2015_231	RD2015_4689	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.	0.778
ALV04736.1	ALV04735.1	RD2015_232	RD2015_231	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	0.998
ALV04736.1	ALV04737.1	RD2015_232	RD2015_233	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter.	0.999
ALV04736.1	ALV07180.1	RD2015_232	RD2015_2715	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Pfam:pfam02391 MoaE protein.	0.493
ALV04736.1	ALV07290.1	RD2015_232	RD2015_2825	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdenum cofactor biosynthesis protein MogA; Pfam:pfam00994 Probable molybdopterin binding domain.	0.637
ALV04736.1	ALV07490.1	RD2015_232	RD2015_3029	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.736
ALV04736.1	ALV08252.1	RD2015_232	RD2015_3801	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdopterin biosynthesis protein MoeB; Pfam:pfam00899 ThiF family.	0.444
ALV04736.1	ALV08526.1	RD2015_232	RD2015_4077	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Hypothetical protein; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	0.973
ALV04736.1	moaA	RD2015_232	RD2015_3437	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Cyclic pyranopterin monophosphate synthase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.765
ALV04736.1	moaC	RD2015_232	RD2015_4689	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.	0.793
ALV04737.1	ALV04735.1	RD2015_233	RD2015_231	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter.	Molybdate ABC transporter, periplasmic molybdate-binding protein ModA; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	0.978
ALV04737.1	ALV04736.1	RD2015_233	RD2015_232	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter.	Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.	0.999
ALV04737.1	ALV08526.1	RD2015_233	RD2015_4077	Molybdate ABC transporter, ATP-binding protein; Pfam:pfam00005 ABC transporter.	Hypothetical protein; Pfam:pfam13531 Bacterial extracellular solute-binding protein.	0.840