STRINGSTRING
ALV05520.1 ALV05520.1 rppH rppH ALV05644.1 ALV05644.1 ALV05784.1 ALV05784.1 ALV05815.1 ALV05815.1 ALV05888.1 ALV05888.1 rnhB rnhB ALV06026.1 ALV06026.1 ALV06028.1 ALV06028.1 ALV06029.1 ALV06029.1 ALV06072.1 ALV06072.1 ALV06094.1 ALV06094.1 ALV06126.1 ALV06126.1 xseB xseB ALV04670.1 ALV04670.1 ALV06178.1 ALV06178.1 ALV04686.1 ALV04686.1 ALV06322.1 ALV06322.1 ALV06377.1 ALV06377.1 ALV06379.1 ALV06379.1 dut dut surE surE ALV04718.1 ALV04718.1 ALV07011.1 ALV07011.1 ALV07107.1 ALV07107.1 ALV07172.1 ALV07172.1 ALV07173.1 ALV07173.1 ALV07238.1 ALV07238.1 ALV07256.1 ALV07256.1 ALV07283.1 ALV07283.1 ALV07305.1 ALV07305.1 pnp pnp ALV07498.1 ALV07498.1 ALV04807.1 ALV04807.1 ALV07529.1 ALV07529.1 ALV07598.1 ALV07598.1 ALV07599.1 ALV07599.1 ALV07600.1 ALV07600.1 xseA xseA ALV07882.1 ALV07882.1 ALV07886.1 ALV07886.1 ALV07887.1 ALV07887.1 ALV07888.1 ALV07888.1 ALV07889.1 ALV07889.1 ALV07890.1 ALV07890.1 ALV07891.1 ALV07891.1 ALV07902.1 ALV07902.1 ALV08009.1 ALV08009.1 ALV08063.1 ALV08063.1 ALV04866.1 ALV04866.1 kynB kynB kynU kynU kynA kynA ALV08162.1 ALV08162.1 rph rph ALV08166.1 ALV08166.1 rnhA rnhA ALV08391.1 ALV08391.1 rne rne ALV04906.1 ALV04906.1 ALV08480.1 ALV08480.1 ALV04910.1 ALV04910.1 RD2015_41 RD2015_41 ALV08598.1 ALV08598.1 ALV08670.1 ALV08670.1 ALV08671.1 ALV08671.1 ALV08691.1 ALV08691.1 ALV08704.1 ALV08704.1 ALV08776.1 ALV08776.1 ALV08794.1 ALV08794.1 ALV08795.1 ALV08795.1 ALV08816.1 ALV08816.1 ALV08843.1 ALV08843.1 ALV08856.1 ALV08856.1 ALV09059.1 ALV09059.1 ALV09136.1 ALV09136.1 ALV04977.1 ALV04977.1 ALV09205.1 ALV09205.1 ALV09206.1 ALV09206.1 ALV09214.1 ALV09214.1 ALV09215.1 ALV09215.1 ALV04999.1 ALV04999.1 ALV05100.1 ALV05100.1 ALV05194.1 ALV05194.1 ALV05212.1 ALV05212.1 ALV05259.1 ALV05259.1 ALV05320.1 ALV05320.1 ALV05338.1 ALV05338.1 ALV05339.1 ALV05339.1 ALV05348.1 ALV05348.1 ALV05377.1 ALV05377.1 RD2015_90 RD2015_90 RD2015_93 RD2015_93 ALV05470.1 ALV05470.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ALV05520.1Pfam:pfam12697 Alpha/beta hydrolase family. (311 aa)
rppHRNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (216 aa)
ALV05644.1Hypothetical protein; Pfam:pfam07589 PEP-CTERM motif. (254 aa)
ALV05784.1Pfam:pfam07793 Protein of unknown function (DUF1631). (837 aa)
ALV05815.1Xanthine dehydrogenase accessory protein XdhC; Pfam:pfam13478 XdhC Rossmann domain. (269 aa)
ALV05888.12-alkenal reductase; Pfam:pfam00107 Zinc-binding dehydrogenase. (339 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (257 aa)
ALV06026.1FAD-dependent oxidoreductase; Pfam:pfam01494 FAD binding domain. (605 aa)
ALV06028.1Pfam:pfam04209 homogentisate 1,2-dioxygenase. (445 aa)
ALV06029.1Fumarylacetoacetase; Pfam:pfam01557 Fumarylacetoacetate (FAA) hydrolase family. (448 aa)
ALV06072.12-hydroxychromene-2-carboxylate isomerase; Pfam:pfam01323 DSBA-like thioredoxin domain. (200 aa)
ALV06094.1Pfam:pfam00724 NADH:flavin oxidoreductase / NADH oxidase family. (367 aa)
ALV06126.1Dienelactone hydrolase-like enzyme; Pfam:pfam01738 Dienelactone hydrolase family. (289 aa)
xseBExodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (94 aa)
ALV04670.1Chloroperoxidase; Pfam:pfam12697 Alpha/beta hydrolase family. (328 aa)
ALV06178.1Membrane protein; Pfam:pfam07681 DoxX. (183 aa)
ALV04686.1GTN reductase; Pfam:pfam00724 NADH:flavin oxidoreductase / NADH oxidase family. (358 aa)
ALV06322.1Putative hydrolase or acyltransferase of alpha/beta superfamily; Pfam:pfam12697 Alpha/beta hydrolase family. (324 aa)
ALV06377.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (143 aa)
ALV06379.1Deoxyribose-phosphate aldolase DeoC; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (258 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa)
surE5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (251 aa)
ALV04718.1Fumarylacetoacetase; Pfam:pfam01557 Fumarylacetoacetate (FAA) hydrolase family. (232 aa)
ALV07011.1Pruvate-binding protein; Pfam:pfam13449 Esterase-like activity of phytase. (485 aa)
ALV07107.1Hypothetical protein. (181 aa)
ALV07172.1(2Fe-2S)-binding domain protein; Pfam:pfam01799 [2Fe-2S] binding domain. (289 aa)
ALV07173.1Xanthine dehydrogenase; Pfam:pfam00941 FAD binding domain in molybdopterin dehydrogenase. (321 aa)
ALV07238.12`,3`-cyclic-nucleotide 2`-phosphodiesterase; Pfam:pfam02872 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. (655 aa)
ALV07256.1NADH pyrophosphatase; Pfam:pfam00293 NUDIX domain. (175 aa)
ALV07283.1Pfam:pfam01126 Heme oxygenase. (218 aa)
ALV07305.1Pfam:pfam02872 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. (590 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (710 aa)
ALV07498.1Hypothetical protein; Pfam:pfam08282 haloacid dehalogenase-like hydrolase. (291 aa)
ALV04807.1Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family; Pfam:pfam13478 XdhC Rossmann domain. (332 aa)
ALV07529.1Hypothetical protein; Pfam:pfam13449 Esterase-like activity of phytase. (395 aa)
ALV07598.1Amidohydrolase; Pfam:pfam07969 Amidohydrolase family. (630 aa)
ALV07599.1DoxX family protein; Pfam:pfam07681 DoxX. (145 aa)
ALV07600.1Carboxymethylenebutenolidase; Pfam:pfam01738 Dienelactone hydrolase family. (269 aa)
xseAExodeoxyribonuclease VII; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (519 aa)
ALV07882.1Phenylacetic acid degradation protein paaN; Pfam:pfam00171 Aldehyde dehydrogenase family. (685 aa)
ALV07886.1Phenylacetate-CoA oxygenase, PaaJ subunit; Pfam:pfam01883 Domain of unknown function DUF59. (182 aa)
ALV07887.1Phenylacetate-CoA oxygenase, PaaI subunit; Pfam:pfam05138 Phenylacetic acid catabolic protein. (271 aa)
ALV07888.1phenylacetate-CoA oxygenase subunit PaaB; Pfam:pfam06243 Phenylacetic acid degradation B. (101 aa)
ALV07889.1phenylacetate-CoA oxygenase; Pfam:pfam05138 Phenylacetic acid catabolic protein. (333 aa)
ALV07890.1Phenylacetate-coenzyme A ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (436 aa)
ALV07891.1Phenylacetic acid degradation protein; Pfam:pfam03061 Thioesterase superfamily. (166 aa)
ALV07902.1Hypothetical protein. (194 aa)
ALV08009.1RNA helicase; Pfam:pfam00270 DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (653 aa)
ALV08063.12-hydroxychromene-2-carboxylate isomerase; Pfam:pfam01323 DSBA-like thioredoxin domain. (215 aa)
ALV04866.1Pfam:pfam01557 Fumarylacetoacetate (FAA) hydrolase family. (410 aa)
kynBKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. (209 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (432 aa)
kynATryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (300 aa)
ALV08162.1Hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (243 aa)
ALV08166.1TIGR00255 family protein; Pfam:pfam08340 Domain of unknown function (DUF1732). (300 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (158 aa)
ALV08391.1Mazg nucleotide pyrophosphohydrolase. (396 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1060 aa)
ALV04906.1Monooxygenase FAD-binding protein; Pfam:pfam01494 FAD binding domain. (424 aa)
ALV08480.1Pfam:pfam00270 DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (505 aa)
ALV04910.1Fumarylacetoacetase domain-containing protein; Pfam:pfam01557 Fumarylacetoacetate (FAA) hydrolase family. (261 aa)
RD2015_41Pfam:pfam12697 Alpha/beta hydrolase family. (299 aa)
ALV08598.1Hypothetical protein. (196 aa)
ALV08670.1RNA helicase; Pfam:pfam00270 DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (446 aa)
ALV08671.1Pfam:pfam00270 DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (446 aa)
ALV08691.1Pfam:pfam12697 Alpha/beta hydrolase family. (310 aa)
ALV08704.1Pfam:pfam07793 Protein of unknown function (DUF1631). (671 aa)
ALV08776.1Phenylacetate-coenzyme A ligase; Pfam:pfam00501 AMP-binding enzyme. (449 aa)
ALV08794.1Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein; Pfam:pfam01799 [2Fe-2S] binding domain. (158 aa)
ALV08795.1Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL-like protein; Pfam:pfam02738 Molybdopterin-binding domain of aldehyde dehydrogenase. (720 aa)
ALV08816.1Pfam:pfam02230 Phospholipase/Carboxylesterase. (228 aa)
ALV08843.1Assimilatory nitrite reductase (NAD(P)H) large subunit; Pfam:pfam07992 Pyridine nucleotide-disulphide oxidoreductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (836 aa)
ALV08856.1Pfam:pfam03992 Antibiotic biosynthesis monooxygenase. (121 aa)
ALV09059.1Hydrolase; Pfam:pfam02230 Phospholipase/Carboxylesterase. (234 aa)
ALV09136.1Pfam:pfam02112 cAMP phosphodiesterases class-II. (260 aa)
ALV04977.1Hypothetical protein. (339 aa)
ALV09205.1(2Fe-2S)-binding protein; Pfam:pfam01799 [2Fe-2S] binding domain. (159 aa)
ALV09206.1Putative isoquinoline 1-oxidoreductase beta subunit; Pfam:pfam02738 Molybdopterin-binding domain of aldehyde dehydrogenase. (746 aa)
ALV09214.1Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS-like protein; Pfam:pfam01799 [2Fe-2S] binding domain. (167 aa)
ALV09215.1Pfam:pfam02738 Molybdopterin-binding domain of aldehyde dehydrogenase. (734 aa)
ALV04999.1Pfam:pfam01738 Dienelactone hydrolase family. (222 aa)
ALV05100.1Pfam:pfam07793 Protein of unknown function (DUF1631). (824 aa)
ALV05194.1DoxD-like family protein; Pfam:pfam07681 DoxX. (282 aa)
ALV05212.1Hypothetical protein; Pfam:pfam12697 Alpha/beta hydrolase family. (259 aa)
ALV05259.1Hypothetical protein. (640 aa)
ALV05320.1DNA-binding protein. (99 aa)
ALV05338.1Pfam:pfam00941 FAD binding domain in molybdopterin dehydrogenase. (369 aa)
ALV05339.1(2Fe-2S)-binding protein; Pfam:pfam01799 [2Fe-2S] binding domain. (222 aa)
ALV05348.12-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; Pfam:pfam01557 Fumarylacetoacetate (FAA) hydrolase family. (273 aa)
ALV05377.1Pfam:pfam12697 Alpha/beta hydrolase family. (277 aa)
RD2015_90Putative signal peptide protein; Pfam:pfam02265 S1/P1 Nuclease. (345 aa)
RD2015_93MazG nucleotide pyrophosphohydrolase. (109 aa)
ALV05470.1Deoxyguanosinetriphosphate triphosphohydrolase; Pfam:pfam13286 Phosphohydrolase-associated domain; Belongs to the dGTPase family. Type 2 subfamily. (379 aa)
Your Current Organism:
Roseateles depolymerans
NCBI taxonomy Id: 76731
Other names: CCUG 52219, DSM 11813, R. depolymerans, proteobacterium DSM11813, proteobacterium DSM11814, strain 61A
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