(35 nodes) Mixed, incl. Protein insertion into ER membrane, and EMC complex network (Aspergillus brasiliensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L9U2E2	Zn(2)-C6 fungal-type domain-containing protein. (529 aa)
	A0A1L9U315	Uncharacterized protein. (133 aa)
	A0A1L9U4P4	TPR_REGION domain-containing protein. (321 aa)
	A0A1L9U6V0	Uncharacterized protein. (175 aa)
	A0A1L9UC63	DUF2012 domain-containing protein. (274 aa)
	A0A1L9UC86	Uncharacterized protein. (347 aa)
	A0A1L9UFD2	Zn(2)-C6 fungal-type domain-containing protein. (617 aa)
	A0A1L9UFH7	Zn(2)-C6 fungal-type domain-containing protein. (513 aa)
	A0A1L9UFY2	Uncharacterized protein. (512 aa)
	A0A1L9UH30	Uncharacterized protein. (322 aa)
	A0A1L9UH44	Uncharacterized protein. (792 aa)
	A0A1L9UHR7	Uncharacterized protein. (209 aa)
	A0A1L9UHW5	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (491 aa)
	GET1	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. (196 aa)
	A0A1L9UIG0	Uncharacterized protein. (623 aa)
	A0A1L9UIY3	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (267 aa)
	A0A1L9UJW7	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (186 aa)
	A0A1L9UK28	Uncharacterized protein. (477 aa)
	A0A1L9UK40	Uncharacterized protein. (220 aa)
	A0A1L9UK90	Uncharacterized protein. (187 aa)
	A0A1L9UKH8	Uncharacterized protein. (388 aa)
	A0A1L9ULJ4	EMC1_C domain-containing protein. (947 aa)
	A0A1L9UNF4	Uncharacterized protein. (597 aa)
	A0A1L9UQ01	Uncharacterized protein. (125 aa)
	A0A1L9UQJ1	HTH La-type RNA-binding domain-containing protein. (752 aa)
	A0A1L9UQP1	Protein transport protein SFT2; Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Belongs to the SFT2 family. (217 aa)
	A0A1L9UQZ3	GRIP domain-containing protein. (532 aa)
	A0A1L9URC1	DUF4045 domain-containing protein. (2156 aa)
	A0A1L9URN3	CASP_C domain-containing protein. (759 aa)
	A0A1L9URR0	Uncharacterized protein. (256 aa)
	A0A1L9UTK6	Uncharacterized protein. (145 aa)
	GET3	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (341 aa)
	A0A1L9UY70	Uncharacterized protein. (144 aa)
	A0A1L9V0B5	Uncharacterized protein. (360 aa)
	A0A1L9V209	Zn(2)-C6 fungal-type domain-containing protein. (465 aa)

Your Current Organism:

Aspergillus brasiliensis

NCBI taxonomy Id: 767769
Other names: A. brasiliensis CBS 101740, Aspergillus brasiliensis CBS 101740

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L9U2E2	A0A1L9UC86	A0A1L9U2E2	A0A1L9UC86	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.455
A0A1L9U2E2	GET1	A0A1L9U2E2	A0A1L9UIB9	Zn(2)-C6 fungal-type domain-containing protein.	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.857
A0A1L9U2E2	GET3	A0A1L9U2E2	A0A1L9UWV0	Zn(2)-C6 fungal-type domain-containing protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.803
A0A1L9U315	A0A1L9UC86	A0A1L9U315	A0A1L9UC86	Uncharacterized protein.	Uncharacterized protein.	0.709
A0A1L9U315	A0A1L9URN3	A0A1L9U315	A0A1L9URN3	Uncharacterized protein.	CASP_C domain-containing protein.	0.457
A0A1L9U315	GET3	A0A1L9U315	A0A1L9UWV0	Uncharacterized protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.429
A0A1L9U4P4	A0A1L9UC63	A0A1L9U4P4	A0A1L9UC63	TPR_REGION domain-containing protein.	DUF2012 domain-containing protein.	0.955
A0A1L9U4P4	A0A1L9UIY3	A0A1L9U4P4	A0A1L9UIY3	TPR_REGION domain-containing protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.990
A0A1L9U4P4	A0A1L9UJW7	A0A1L9U4P4	A0A1L9UJW7	TPR_REGION domain-containing protein.	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	0.988
A0A1L9U4P4	A0A1L9ULJ4	A0A1L9U4P4	A0A1L9ULJ4	TPR_REGION domain-containing protein.	EMC1_C domain-containing protein.	0.991
A0A1L9U4P4	A0A1L9UQ01	A0A1L9U4P4	A0A1L9UQ01	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.946
A0A1L9U4P4	A0A1L9UTK6	A0A1L9U4P4	A0A1L9UTK6	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.991
A0A1L9U6V0	A0A1L9UC86	A0A1L9U6V0	A0A1L9UC86	Uncharacterized protein.	Uncharacterized protein.	0.426
A0A1L9U6V0	A0A1L9UK90	A0A1L9U6V0	A0A1L9UK90	Uncharacterized protein.	Uncharacterized protein.	0.619
A0A1L9U6V0	GET1	A0A1L9U6V0	A0A1L9UIB9	Uncharacterized protein.	Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.605
A0A1L9U6V0	GET3	A0A1L9U6V0	A0A1L9UWV0	Uncharacterized protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.624
A0A1L9UC63	A0A1L9U4P4	A0A1L9UC63	A0A1L9U4P4	DUF2012 domain-containing protein.	TPR_REGION domain-containing protein.	0.955
A0A1L9UC63	A0A1L9UIY3	A0A1L9UC63	A0A1L9UIY3	DUF2012 domain-containing protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.967
A0A1L9UC63	A0A1L9UJW7	A0A1L9UC63	A0A1L9UJW7	DUF2012 domain-containing protein.	ER membrane protein complex subunit 4; Belongs to the EMC4 family.	0.975
A0A1L9UC63	A0A1L9ULJ4	A0A1L9UC63	A0A1L9ULJ4	DUF2012 domain-containing protein.	EMC1_C domain-containing protein.	0.954