(141 nodes) Preribosome, and Ribosome biogenesis network (Aspergillus brasiliensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1L9U2Q1	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family. (112 aa)
	A0A1L9U305	Uncharacterized protein. (114 aa)
	A0A1L9U4B5	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (259 aa)
	A0A1L9U4S2	WD_REPEATS_REGION domain-containing protein. (927 aa)
	A0A1L9U4V0	Uncharacterized protein. (220 aa)
	A0A1L9U4V2	Uncharacterized protein. (306 aa)
	A0A1L9U4Y9	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (212 aa)
	A0A1L9U4Z7	zf-LYAR domain-containing protein. (526 aa)
	A0A1L9U5E2	Uncharacterized protein. (1828 aa)
	A0A1L9U5P3	RNase_PH domain-containing protein. (324 aa)
	A0A1L9U664	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (687 aa)
	A0A1L9U666	60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (188 aa)
	A0A1L9U689	Uncharacterized protein. (114 aa)
	A0A1L9U690	Uncharacterized protein. (359 aa)
	A0A1L9U6A3	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (526 aa)
	A0A1L9U6A5	Peptidase_M24 domain-containing protein. (406 aa)
	A0A1L9U6N7	Uncharacterized protein. (292 aa)
	A0A1L9U6Q4	Uncharacterized protein. (832 aa)
	A0A1L9U6Y1	S4 RNA-binding domain-containing protein. (188 aa)
	A0A1L9U8E6	Uncharacterized protein. (241 aa)
	A0A1L9U8F6	Uncharacterized protein. (249 aa)
	SPB1	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (805 aa)
	A0A1L9U9B7	Uncharacterized protein; Belongs to the DEAD box helicase family. (781 aa)
	A0A1L9UAG8	CP-type G domain-containing protein. (664 aa)
	A0A1L9UAI6	Uncharacterized protein. (493 aa)
	A0A1L9UAK2	Uncharacterized protein. (294 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (247 aa)
	A0A1L9UAU7	Brix domain-containing protein. (446 aa)
	A0A1L9UBL7	Uncharacterized protein. (1112 aa)
	A0A1L9UBN3	Protein MAK16; Belongs to the MAK16 family. (332 aa)
	A0A1L9UBR7	Uncharacterized protein. (1196 aa)
	A0A1L9UBV6	Uncharacterized protein. (186 aa)
	A0A1L9UC54	Uncharacterized protein. (358 aa)
	A0A1L9UC85	Fcf2 domain-containing protein. (240 aa)
	A0A1L9UCA4	Uncharacterized protein. (293 aa)
	A0A1L9UCC4	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (437 aa)
	A0A1L9UCJ7	WD_REPEATS_REGION domain-containing protein. (903 aa)
	A0A1L9UE44	RNase_PH domain-containing protein. (403 aa)
	A0A1L9UFN0	RIO domain-containing protein. (403 aa)
	A0A1L9UG56	WD_REPEATS_REGION domain-containing protein. (447 aa)
	A0A1L9UG60	Uncharacterized protein; Belongs to the DEAD box helicase family. (467 aa)
	A0A1L9UG63	Brix domain-containing protein. (451 aa)
	A0A1L9UGD5	Uncharacterized protein. (530 aa)
	A0A1L9UGI9	Uncharacterized protein. (279 aa)
	A0A1L9UGP7	Uncharacterized protein. (259 aa)
	A0A1L9UH37	Utp12 domain-containing protein. (848 aa)
	A0A1L9UHJ9	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (560 aa)
	A0A1L9UHZ0	Uncharacterized protein. (512 aa)
	NOP7	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (671 aa)
	YTM1	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (490 aa)
	A0A1L9UI59	WD_REPEATS_REGION domain-containing protein. (976 aa)
	A0A1L9UI66	Uncharacterized protein. (620 aa)
	A0A1L9UIC6	Uncharacterized protein. (719 aa)
	A0A1L9UID2	RRM domain-containing protein. (467 aa)
	A0A1L9UIL6	Uncharacterized protein. (919 aa)
	A0A1L9UIR9	CAP-Gly domain-containing protein. (1134 aa)
	A0A1L9UIS4	RRM domain-containing protein. (517 aa)
	A0A1L9UIW8	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (712 aa)
	A0A1L9UJ18	CBF domain-containing protein. (549 aa)
	A0A1L9UJK5	Importin N-terminal domain-containing protein. (1045 aa)
	A0A1L9UJZ4	Nop domain-containing protein. (519 aa)
	A0A1L9UK34	Uncharacterized protein. (393 aa)
	A0A1L9UKI5	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (689 aa)
	A0A1L9UKP3	Uncharacterized protein. (364 aa)
	A0A1L9UL45	Uncharacterized protein. (407 aa)
	A0A1L9ULJ1	WD_REPEATS_REGION domain-containing protein. (541 aa)
	A0A1L9ULT2	MI domain-containing protein. (876 aa)
	A0A1L9ULZ0	Uncharacterized protein. (279 aa)
	A0A1L9UM96	TRASH domain-containing protein. (189 aa)
	A0A1L9UMJ2	RNase_PH domain-containing protein. (269 aa)
	A0A1L9UMP6	Uncharacterized protein. (957 aa)
	A0A1L9UNA3	Uncharacterized protein. (391 aa)
	A0A1L9UNE2	C2H2-type domain-containing protein. (113 aa)
	A0A1L9UNW2	RNA helicase. (802 aa)
	A0A1L9UPB5	BP28CT domain-containing protein. (1798 aa)
	A0A1L9UPH9	ATP-dependent RNA helicase DBP10. (937 aa)
	A0A1L9UQ21	Brix domain-containing protein. (298 aa)
	A0A1L9UQ47	CBF domain-containing protein. (1127 aa)
	A0A1L9UQA1	RNB domain-containing protein. (1370 aa)
	A0A1L9UQC1	Uncharacterized protein. (327 aa)
	A0A1L9UQF3	CP-type G domain-containing protein. (540 aa)
	A0A1L9UQP4	Sas10 domain-containing protein. (653 aa)
	A0A1L9UQS6	PUM-HD domain-containing protein. (700 aa)
	ERB1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (787 aa)
	A0A1L9UR13	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (661 aa)
	A0A1L9URG9	Uncharacterized protein. (836 aa)
	A0A1L9URJ1	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (745 aa)
	A0A1L9URK9	Uncharacterized protein. (298 aa)
	A0A1L9URL2	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (875 aa)
	A0A1L9URT9	Uncharacterized protein. (795 aa)
	A0A1L9URW2	Uncharacterized protein. (727 aa)
	A0A1L9URY4	Uncharacterized protein. (315 aa)
	A0A1L9USC7	RNA helicase. (607 aa)
	A0A1L9USP8	Uncharacterized protein; Belongs to the RNR ribonuclease family. (1033 aa)
	A0A1L9UT69	PPM-type phosphatase domain-containing protein. (1231 aa)
	A0A1L9UTE9	Brix domain-containing protein. (674 aa)
	A0A1L9UTH7	WD_REPEATS_REGION domain-containing protein. (962 aa)
	A0A1L9UTM7	WD_REPEATS_REGION domain-containing protein. (536 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1068 aa)
	A0A1L9UU45	Uncharacterized protein. (825 aa)
	A0A1L9UU76	Uncharacterized protein. (975 aa)
	A0A1L9UU99	Uncharacterized protein. (548 aa)
	A0A1L9UUG0	Uncharacterized protein. (374 aa)
	A0A1L9UUQ5	Uncharacterized protein. (1032 aa)
	A0A1L9UUT5	Uncharacterized protein. (493 aa)
	A0A1L9UUU8	S4 RNA-binding domain-containing protein; Belongs to the universal ribosomal protein uS4 family. (193 aa)
	A0A1L9UV30	WD_REPEATS_REGION domain-containing protein. (610 aa)
	A0A1L9UV32	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (125 aa)
	A0A1L9UVU6	Uncharacterized protein. (261 aa)
	A0A1L9UW21	Nop domain-containing protein. (581 aa)
	A0A1L9UW93	RNA helicase. (642 aa)
	A0A1L9UWV4	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (201 aa)
	A0A1L9UWW5	Uncharacterized protein; Belongs to the universal ribosomal protein uS11 family. (105 aa)
	A0A1L9UWY9	Uncharacterized protein; Belongs to the DEAD box helicase family. (522 aa)
	A0A1L9UX22	Bms1-type G domain-containing protein. (1180 aa)
	A0A1L9UX83	Uncharacterized protein. (619 aa)
	A0A1L9UXD9	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (566 aa)
	A0A1L9UXL7	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (364 aa)
	A0A1L9UXV2	NUC173 domain-containing protein. (1279 aa)
	A0A1L9UXX4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (655 aa)
	A0A1L9UY07	RNase_PH domain-containing protein. (388 aa)
	A0A1L9UY40	WD_REPEATS_REGION domain-containing protein. (535 aa)
	A0A1L9UY59	Bms1-type G domain-containing protein. (802 aa)
	A0A1L9UZ85	Uncharacterized protein. (378 aa)
	A0A1L9UZM3	Uncharacterized protein. (720 aa)
	A0A1L9UZP1	Uncharacterized protein; Belongs to the DEAD box helicase family. (656 aa)
	A0A1L9UZS0	Uncharacterized protein. (291 aa)
	A0A1L9UZV3	PINc domain-containing protein. (511 aa)
	A0A1L9V0W0	Uncharacterized protein. (984 aa)
	A0A1L9V0W1	WD_REPEATS_REGION domain-containing protein. (495 aa)
	A0A1L9V103	DRIM domain-containing protein. (2611 aa)
	A0A1L9V1A9	C2H2-type domain-containing protein. (442 aa)
	A0A1L9V1P1	NUC153 domain-containing protein. (731 aa)
	A0A1L9V218	Uncharacterized protein; Belongs to the DEAD box helicase family. (765 aa)
	A0A1L9V2B7	Uncharacterized protein. (564 aa)
	A0A1L9V2N6	NUC153 domain-containing protein. (729 aa)
	A0A1L9V2W1	Uncharacterized protein. (224 aa)
	A0A1L9V331	Uncharacterized protein. (259 aa)
	A0A1L9V332	ECR1_N domain-containing protein. (741 aa)
	A0A1L9V390	RRM domain-containing protein. (296 aa)
	A0A1L9V397	U3 small nucleolar RNA-associated protein 22. (1116 aa)

Your Current Organism:

Aspergillus brasiliensis

NCBI taxonomy Id: 767769
Other names: A. brasiliensis CBS 101740, Aspergillus brasiliensis CBS 101740

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1L9U2Q1	A0A1L9U305	A0A1L9U2Q1	A0A1L9U305	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.822
A0A1L9U2Q1	A0A1L9U4Y9	A0A1L9U2Q1	A0A1L9U4Y9	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.977
A0A1L9U2Q1	A0A1L9U4Z7	A0A1L9U2Q1	A0A1L9U4Z7	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	zf-LYAR domain-containing protein.	0.536
A0A1L9U2Q1	A0A1L9U689	A0A1L9U2Q1	A0A1L9U689	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.822
A0A1L9U2Q1	A0A1L9U690	A0A1L9U2Q1	A0A1L9U690	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.627
A0A1L9U2Q1	A0A1L9U6A5	A0A1L9U2Q1	A0A1L9U6A5	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Peptidase_M24 domain-containing protein.	0.941
A0A1L9U2Q1	A0A1L9U8E6	A0A1L9U2Q1	A0A1L9U8E6	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.642
A0A1L9U2Q1	A0A1L9U9B7	A0A1L9U2Q1	A0A1L9U9B7	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.512
A0A1L9U2Q1	A0A1L9UAG8	A0A1L9U2Q1	A0A1L9UAG8	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	CP-type G domain-containing protein.	0.606
A0A1L9U2Q1	A0A1L9UBN3	A0A1L9U2Q1	A0A1L9UBN3	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Protein MAK16; Belongs to the MAK16 family.	0.557
A0A1L9U2Q1	A0A1L9UBV6	A0A1L9U2Q1	A0A1L9UBV6	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.788
A0A1L9U2Q1	A0A1L9UC54	A0A1L9U2Q1	A0A1L9UC54	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.770
A0A1L9U2Q1	A0A1L9UC85	A0A1L9U2Q1	A0A1L9UC85	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Fcf2 domain-containing protein.	0.493
A0A1L9U2Q1	A0A1L9UCA4	A0A1L9U2Q1	A0A1L9UCA4	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.515
A0A1L9U2Q1	A0A1L9UG60	A0A1L9U2Q1	A0A1L9UG60	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.628
A0A1L9U2Q1	A0A1L9UG63	A0A1L9U2Q1	A0A1L9UG63	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Brix domain-containing protein.	0.420
A0A1L9U2Q1	A0A1L9UGD5	A0A1L9U2Q1	A0A1L9UGD5	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.493
A0A1L9U2Q1	A0A1L9UGP7	A0A1L9U2Q1	A0A1L9UGP7	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.661
A0A1L9U2Q1	A0A1L9UHJ9	A0A1L9U2Q1	A0A1L9UHJ9	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.963
A0A1L9U2Q1	A0A1L9UIC6	A0A1L9U2Q1	A0A1L9UIC6	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	Uncharacterized protein.	0.643