Your Input: | |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (205 aa) |
| | fhs | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (586 aa) |
| | AGK99777.1 | UTP:GlnB (protein PII) uridylyltransferase; PFAM: HD domain. (202 aa) |
| | AGK99778.1 | Dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. (394 aa) |
| | AGK99779.1 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (133 aa) |
| | AGK99780.1 | PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (173 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | panD | L-aspartate-alpha-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (306 aa) |
| | AGK99875.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (527 aa) |
| | AGK99876.1 | Nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (287 aa) |
| | coaX | Pantothenate kinase, type III; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa) |
| | AGK99919.1 | PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase. (229 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa) |
| | AGK99988.1 | NAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family. (250 aa) |
| | AGL00023.1 | PFAM: Inositol monophosphatase family. (273 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase, common form; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (291 aa) |
| | argD | PFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (428 aa) |
| | AGL00030.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (303 aa) |
| | argG | PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argH | PFAM: Lyase; TIGRFAM: argininosuccinate lyase. (456 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1076 aa) |
| | cinA | PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; molybdenum cofactor synthesis domain. (412 aa) |
| | AGL00302.1 | PFAM: Permease family. (429 aa) |
| | AGL00335.1 | PFAM: Permease family. (458 aa) |
| | AGL00422.1 | PFAM: Phosphoribosyl transferase domain; TIGRFAM: uracil phosphoribosyltransferase; Belongs to the UPRTase family. (212 aa) |
| | AGL00423.1 | PFAM: Permease family; TIGRFAM: uracil-xanthine permease. (427 aa) |
| | AGL00647.1 | Dihydroorotase-like cyclic amidohydrolase; PFAM: Amidohydrolase family. (450 aa) |
| | AGL00736.1 | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; manually curated; Belongs to the cysteine synthase/cystathionine beta- synthase family. (336 aa) |
| | AGL00788.1 | Periplasmic component of amino acid ABC-type transporter/signal transduction system; PFAM: Bacterial extracellular solute-binding proteins, family 3. (274 aa) |
| | AGL00990.1 | Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; PFAM: Aminotransferase class I and II. (396 aa) |
| | AGL01064.1 | Hypothetical protein; PFAM: Domain of unknown function (DUF2520); Rossmann-like domain. (292 aa) |
| | AGL01086.1 | Zn-finger containing NTP pyrophosphohydrolase; PFAM: NADH pyrophosphatase zinc ribbon domain; NUDIX domain; NADH pyrophosphatase-like rudimentary NUDIX domain. (266 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (242 aa) |
| | AGL01262.1 | Periplasmic component of amino acid ABC-type transporter/signal transduction system; PFAM: Bacterial extracellular solute-binding proteins, family 3. (285 aa) |
| | AGL01263.1 | PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; manually curated. (224 aa) |
| | AGL01264.1 | ABC-type polar amino acid transport system, ATPase component; PFAM: ABC transporter. (251 aa) |
| | AGL01296.1 | PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (313 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (149 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (266 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | AGL01315.1 | PFAM: Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (408 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | AGL01328.1 | PFAM: Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; Belongs to the CinA family. (171 aa) |
| | AGL01337.1 | PFAM: Aminotransferase class I and II. (392 aa) |
| | guaB | Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (287 aa) |
| | surE | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (273 aa) |
| | folE | PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. (186 aa) |
| | AGL01530.1 | Acetyltransferase, N-acetylglutamate synthase; PFAM: Acetyltransferase (GNAT) family; Belongs to the acetyltransferase family. (152 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (277 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (946 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (191 aa) |
| | AGL01577.1 | NAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family. (249 aa) |
| | AGL01590.1 | Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase. (505 aa) |
| | AGL01719.1 | PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, clade 2; aminodeoxychorismate synthase, component I, bacterial clade. (477 aa) |
| | AGL01720.1 | PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (196 aa) |
| | AGL01786.1 | PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing). (614 aa) |
| | AGL01787.1 | Hypothetical protein. (78 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (542 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | hisA | PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (248 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa) |
| | hisB | PFAM: Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (510 aa) |
| | AGL01880.1 | PFAM: Trp repressor protein; TIGRFAM: TrpR-related protein YerC/YecD. (106 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. (421 aa) |
| | purH | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. (513 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (203 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase. (347 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (478 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase. (234 aa) |
| | AGL01907.1 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (177 aa) |
| | AGL01913.1 | PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | AGL01932.1 | PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family. (407 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa) |
| | AGL01934.1 | PFAM: Homoserine dehydrogenase, NAD binding domain; Homoserine dehydrogenase; ACT domain. (430 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | AGL01952.1 | PFAM: Prephenate dehydrogenase; ACT domain. (363 aa) |
| | AGL01953.1 | PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (343 aa) |
| | AGL01954.1 | PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (268 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (448 aa) |
| | nadK | Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (289 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (364 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (313 aa) |
| | AGL02153.1 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa) |
| | AGL02220.1 | Nicotinic acid phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain. (350 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (157 aa) |
| | ribBA | GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (406 aa) |
| | AGL02223.1 | PFAM: Lumazine binding domain; TIGRFAM: riboflavin synthase, alpha subunit. (222 aa) |
| | AGL02224.1 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa) |
| | AGL02378.1 | Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family. (307 aa) |
| | AGL02380.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | AGL02385.1 | PFAM: Aminotransferase class I and II. (397 aa) |
| | dapL | LL-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (394 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa) |
| | pyrF | Orotidine 5''-phosphate decarboxylase, subfamily 1; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (308 aa) |
| | pyrK | 2-polyprenylphenol hydroxylase-like oxidoreductase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (268 aa) |
| | carB-2 | Carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1072 aa) |
| | carA | PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (359 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; manually curated; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa) |
| | pyrR | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (182 aa) |
| | hisC-2 | PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | AGL02616.1 | PFAM: Aminotransferase class I and II. (394 aa) |
| | nadD | Nicotinate/nicotinamide nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (206 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (371 aa) |
| | AGL02655.1 | Folylpolyglutamate synthase/dihydrofolate synthase; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (433 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (291 aa) |
| | AGL02711.1 | PFAM: HD domain; TIGRFAM: putative HD superfamily hydrolase of NAD metabolism; uncharacterized domain HDIG. (188 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | AGL02955.1 | PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; intein N-terminal splicing region. (1141 aa) |
| | nrdR | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (153 aa) |
| | AGL02991.1 | PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. (268 aa) |
| | AGL03063.1 | PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II. (385 aa) |
| | AGL03064.1 | PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (343 aa) |
| | AGL03096.1 | PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase. (276 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (280 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (274 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (294 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | AGL03102.1 | PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. (204 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (491 aa) |
| | AGL03191.1 | PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (476 aa) |
| | AGL03354.1 | PFAM: Phosphoribulokinase / Uridine kinase family. (571 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (183 aa) |
| | trpF-2 | PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (235 aa) |
| | AGL03436.1 | Glutamine phosphoribosylpyrophosphate amidotransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (466 aa) |
| | AGL03568.1 | Xanthosine triphosphate pyrophosphatase; PFAM: Ham1 family; TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family. (189 aa) |
| | AGL03840.1 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region. (149 aa) |
| | glyA | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa) |
| | hisF-2 | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
