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HELO_1022 HELO_1022 metF metF fmt fmt thyA thyA folA folA purH purH purN purN folD folD metF-2 metF-2 fhs fhs gcvT gcvT metH metH purU purU purU-2 purU-2 glyA2 glyA2 glyA1 glyA1 ydgB ydgB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
HELO_10225-formyltetrahydrofolate cyclo-ligase; Specificity unclear; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (206 aa)
metFMethylenetetrahydrofolate reductase 1 - Arabidopsis thaliana (Mouse-ear cress),InterPro: Methylenetetrahydrofolate reductase, High confidence in function and specificity; Belongs to the methylenetetrahydrofolate reductase family. (280 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (326 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (284 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (179 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase - Thiomicrospira crunogena (strain XCL-2),InterPro: AICARFT/IMPCHase bienzyme, High confidence in function and specificity. (526 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (244 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase / cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
metF-2Methylenetetrahydrofolate reductase - Mus musculus (Mouse),InterPro: Methylenetetrahydrofolate reductase, High confidence in function and specificity; Belongs to the methylenetetrahydrofolate reductase family. (354 aa)
fhsFormate--tetrahydrofolate ligase - Sinorhizobium medicae (strain WSM419) (Ensifer medicae),InterPro: Formate-tetrahydrofolate ligase FTHFS, High confidence in function and specificity; Belongs to the formate--tetrahydrofolate ligase family. (584 aa)
gcvTPart of the glycine cleavage multienzyme complex GCV. (369 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1236 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (349 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
glyA2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa)
glyA1Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa)
ydgBShort chain dehydrogenase; 3-oxoacyl-[acyl-carrier-protein] reductase -Thermotoga maritima,InterPro: Short-chain dehydrogenase/reductase SDR, High confidence in function and specificity. (237 aa)
Your Current Organism:
Halomonas elongata
NCBI taxonomy Id: 768066
Other names: H. elongata DSM 2581, Halomonas elongata ATCC 33173, Halomonas elongata DSM 2581, Halomonas elongata str. DSM 2581, Halomonas elongata strain DSM 2581
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