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carB carB purB purB asnB asnB carA carA purA purA guaA guaA pyrD pyrD pyrE pyrE pyrI pyrI pyrF pyrF pyrB pyrB purK purK purK-2 purK-2 ybiK ybiK TTX_1727 TTX_1727 TTX_1832 TTX_1832 pyrC pyrC purF purF purF-2 purF-2 purQ purQ purS purS purD purD purC purC purM purM purN purN purK-3 purK-3 purE purE purL purL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
carBCarbamoyl-phosphate synthase, glutamine dependent, large chain; Belongs to the CarB family. (1018 aa)
purBAdenylosuccinate lyase. (403 aa)
asnBAsparagine synthase (glutamine-hydrolyzing). (295 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (364 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (334 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa)
pyrDDihydroorotate dehydrogenase. (297 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)
pyrIAspartate carbamoyltransferase, regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
pyrFOrotidine-5'-phosphate decarboxylase. (199 aa)
pyrBAspartate carbamoyltransferase catalytic chain. (304 aa)
purKPhosphoribosylaminoimidazole carboxylase. (84 aa)
purK-2Phosphoribosylaminoimidazole carboxylase. (64 aa)
ybiKL-asparaginase. (269 aa)
TTX_1727Adenine/guanine phosphoribosyltransferase related PRPP-binding enzyme. (230 aa)
TTX_1832Xanthine/uracil permease family. (484 aa)
pyrCDihydroorotase. (392 aa)
purFAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (417 aa)
purF-2Amidophosphoribosyltransferase. (371 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (210 aa)
purSPhosphoribosylformylglycinamidine (FGAM) synthase. (86 aa)
purDPhosphoribosylamine--glycine ligase. (485 aa)
purCPhosphoribosylaminoimidazole- succinocarboxamidesynthase; Belongs to the SAICAR synthetase family. (233 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (307 aa)
purNPhosphoribosylglycinamide formyltransferase. (277 aa)
purK-3Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (366 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (152 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (700 aa)
Your Current Organism:
Thermoproteus tenax
NCBI taxonomy Id: 768679
Other names: T. tenax Kra 1, Thermoproteus tenax DSM 2078, Thermoproteus tenax JCM 9277, Thermoproteus tenax Kra 1, Thermoproteus tenax str. Kra 1, Thermoproteus tenax strain Kra 1
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