STRINGSTRING
hxk hxk nuoB nuoB nuoC nuoC TTX_0139 TTX_0139 mvaA mvaA acaB acaB TTX_0173 TTX_0173 TTX_0174 TTX_0174 TTX_0201 TTX_0201 fqoJ/nuoJ fqoJ/nuoJ fqoK/nuoK fqoK/nuoK fqoM/nuoM fqoM/nuoM fqoL/nuoL fqoL/nuoL fqoN/nuoN fqoN/nuoN oorCD oorCD oorA oorA oorB oorB fqoI/nuoI fqoI/nuoI fqoH/nuoH fqoH/nuoH fqoA/nuoA fqoA/nuoA fqoB/nuoB fqoB/nuoB fqoD/nuoD fqoD/nuoD TTX_0216 TTX_0216 acs acs snz1 snz1 pyrOB pyrOB hbd-5 hbd-5 soxN soxN soxL soxL gdh gdh lpd-1 lpd-1 acn acn tpi tpi cis1, cis1, TTX_0522 TTX_0522 nuoD nuoD nuoH nuoH nuoI nuoI nuoJ nuoJ nuoK nuoK nuoM nuoM nuoL nuoL nuoN nuoN acs-4 acs-4 acaB-1 acaB-1 acaB-2 acaB-2 TTX_0568 TTX_0568 TTX_0569 TTX_0569 acd acd deoC deoC ppdK ppdK etfA etfA etfB etfB fixX fixX ydiS ydiS TTX_0793 TTX_0793 TTX_0794 TTX_0794 TTX_0795 TTX_0795 aspC aspC sdhD/frdD sdhD/frdD sdhC/frdC sdhC/frdC sdhB/frdB sdhB/frdB sdhA/frdA sdhA/frdA TTX_0886 TTX_0886 pps pps sucC sucC sucD sucD acyP acyP pgi pgi prsA prsA TTX_1022 TTX_1022 acaB-4 acaB-4 acd-2 acd-2 TTX_1028 TTX_1028 TTX_1029 TTX_1029 TTX_1074a TTX_1074a FixC-2 FixC-2 gdhA gdhA TTX_1099 TTX_1099 acsA acsA TTX_1101 TTX_1101 TTX_1102 TTX_1102 TTX_1103 TTX_1103 frdA frdA frdB frdB TTX_1106 TTX_1106 pepC-1 pepC-1 acaB-3 acaB-3 TTX_1112 TTX_1112 acd-3 acd-3 acd-4 acd-4 acs-2 acs-2 gdhA-2 gdhA-2 TTX_1149 TTX_1149 gad gad kdgA kdgA kdgK kdgK gapN gapN nuoEF nuoEF pfp pfp fba fba fumC fumC glcB glcB dld dld TTX_1318 TTX_1318 TTX_1319 TTX_1319 lctP lctP mdh mdh acs-3 acs-3 oorB-2 oorB-2 oorCA oorCA TTX_1479 TTX_1479 TTX_1488 TTX_1488 icd icd prpD prpD prpB prpB cis2 cis2 mae mae gap gap pgk pgk TTX_1654 TTX_1654 adhP adhP aspC-2 aspC-2 tktB tktB tktA tktA oorB-3 oorB-3 oorCA-2 oorCA-2 acs-2-2 acs-2-2 fbp fbp fumB/ttdB fumB/ttdB fumA/ttdA fumA/ttdA oorC oorC oorD oorD oorA-2 oorA-2 oorB-4 oorB-4 mvk mvk nuoA nuoA pepC-2 pepC-2 rbsK rbsK eno eno pyk pyk fni fni etfA-2 etfA-2 etfB-2 etfB-2 acd-5 acd-5 TTX_2016 TTX_2016 TTX_2025 TTX_2025 oorB-5 oorB-5 oorA-3 oorA-3 oorD-2 oorD-2 oorC-2 oorC-2 gor gor rpiA rpiA gpmA gpmA serA serA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hxkATP-dependent hexokinase. (301 aa)
nuoBFerredoxin:quinone oxidoreductase, complex I, subunit B; Belongs to the complex I 20 kDa subunit family. (194 aa)
nuoCFerredoxin:quinone oxidoreductase, complex I, subunit C. (177 aa)
TTX_0139CoA transferase. (543 aa)
mvaA3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase); Belongs to the HMG-CoA reductase family. (404 aa)
acaBacetyl-CoA C-acyltransferase. (370 aa)
TTX_0173Predicted nucleic-acid-binding protein containing a Zn-ribbon. (132 aa)
TTX_0174Putative 3-hydroxy-3-methylglutaryl-CoA-synthase/3-oxoacyl-[acyl- carrier-protein] synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (349 aa)
TTX_0201Hypothetical protein. (377 aa)
fqoJ/nuoJfqoJ/nuoJ hypothetical protein, ferredoxin:quinone oxidoreductase, complex I, subunit J. (158 aa)
fqoK/nuoKfqoK/nuoK hypothetical protein, ferredoxin:quinone oxidoreductase, complex I, subunit K. (72 aa)
fqoM/nuoMFerredoxin:quinone oxidoreductase, complex I, subunit M. (413 aa)
fqoL/nuoLFerredoxin:quinone oxidoreductase, complex I, subunit L. (521 aa)
fqoN/nuoNFerredoxin:quinone oxidoreductase, complex I, subunit N. (366 aa)
oorCD2-oxoacid ferredoxin oxidoreductase, gamma-delta subunit. (311 aa)
oorA2-oxoacid ferredoxin oxidoreductase, alpha subunit. (398 aa)
oorB2-oxoacid ferredoxin oxidoreductase, beta subunit. (340 aa)
fqoI/nuoIFerredoxin:quinone oxidoreductase, complex I, subunit I. (131 aa)
fqoH/nuoHFerredoxin:quinone oxidoreductase, complex I, subunit H. (316 aa)
fqoA/nuoAFerredoxin:quinone oxidoreductase, complex I, subunit A. (105 aa)
fqoB/nuoBFerredoxin:quinone oxidoreductase, complex I, subunit B; Belongs to the complex I 20 kDa subunit family. (143 aa)
fqoD/nuoDFerredoxin:quinone oxidoreductase, complex I, subunit D; Belongs to the complex I 49 kDa subunit family. (406 aa)
TTX_0216Permease of the major facilitator superfamily. (486 aa)
acsacsA acetyl-CoA synthetase. (570 aa)
snz1Pyridoxine biosynthesis enzyme; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (339 aa)
pyrOBPredicted glutamine amidotransferase involved in pyridoxine biosynthesis; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa)
hbd-5enoyl-CoA hydratase/isomerase. (254 aa)
soxNCytochrome b related protein. (479 aa)
soxLRieske iron-sulfur protein. (261 aa)
gdhGlucose 1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. To a lesser extent, is also active with xylose as substrate, but mannose, arabinose, galactose, fructose 6- phosphate, glucose 6-phosphate, glycerinaldehyde 3-phosphate, ribose, sorbitol, ethanol, erythritol, or lactose are not oxidized by the enzyme. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway; Belongs to the [...] (347 aa)
lpd-1Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (482 aa)
acnAconitate hydratase. (879 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa)
cis1,Citrate synthase 1. (374 aa)
TTX_05223-hydroxyisobutyrate dehydrogenase. (286 aa)
nuoDNADH dehydrogenase I chain D. (404 aa)
nuoHNADH dehydrogenase I chain H. (337 aa)
nuoINADH dehydrogenase I chain I. (164 aa)
nuoJNADH dehydrogenase I chain J. (142 aa)
nuoKNADH dehydrogenase I chain K. (97 aa)
nuoMNADH dehydrogenase I chain M. (486 aa)
nuoLNADH dehydrogenase I chain L. (631 aa)
nuoNNADH dehydrogenase I chain N. (419 aa)
acs-4acetyl-CoA synthetase. (629 aa)
acaB-1Acetyl-CoA C-acyltransferase. (380 aa)
acaB-2acetyl-CoA C-acyltransferase. (395 aa)
TTX_0568Predicted DNA-binding protein, Zn-ribbon domain. (176 aa)
TTX_0569Predicted DNA-binding protein, Zn-ribbon domain. (143 aa)
acdacyl-CoA dehydrogenase. (380 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
ppdKPyruvate, phosphate dikinase. (915 aa)
etfAElectron transfer flavoprotein, alpha-subunit. (346 aa)
etfBElectron transfer flavoprotein, beta-subunit. (264 aa)
fixXFerredoxin-like protein. (97 aa)
ydiSElectron transfer flavoprotein-quinone oxidoreductase. (424 aa)
TTX_0793Permease of the major facilitator superfamily. (424 aa)
TTX_0794D-lactate dehydrogenase. (448 aa)
TTX_0795Conserved hypothetical iron-sulfur protein with C-terminal seven iron ferredoxin domain. (384 aa)
aspCAspartate aminotransferase. (394 aa)
sdhD/frdDSuccinate dehydrogenase (succinate dehydrogenase/fumarate reductase), subunit D. (116 aa)
sdhC/frdCSuccinate dehydrogenase (succinate dehydrogenase/fumarate reductase), cytochrome b subunit. (160 aa)
sdhB/frdBSuccinate dehydrogenase (succinate dehydrogenase/fumarate reductase), iron-sulfur subunit. (237 aa)
sdhA/frdASuccinate dehydrogenase (succinate dehydrogenase/fumarate reductase), flavoprotein subunit. (582 aa)
TTX_0886acetyl-CoA C-acetyltransferase. (395 aa)
ppsPhosphoenolpyruvate synthetase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (810 aa)
sucCsuccinyl-CoA synthetase, beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDsuccinyl-CoA synthetase, alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
acyPAcylphosphatase; Belongs to the acylphosphatase family. (92 aa)
pgiGlucose-6-phosphate isomerase. (298 aa)
prsARibose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (288 aa)
TTX_1022Zn-ribbon nucleic-acid-binding protein. (181 aa)
acaB-4acetyl-CoA acyltransferase. (390 aa)
acd-2acyl-CoA dehydrogenase. (410 aa)
TTX_1028crotonyl-CoA hydratase/(S)-3-hydroxybutyryl-CoA dehydrogenase. (663 aa)
TTX_1029acetoacetyl-CoA beta-ketothiolase. (395 aa)
TTX_1074aAcylphosphatase. (97 aa)
FixC-2Dehydrogenase. (357 aa)
gdhAGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (414 aa)
TTX_1099Hypothetical protein predicted by Glimmer/Critica. (127 aa)
acsAAcetyl-coenzyme A synthetase. (628 aa)
TTX_1101Succinyl-CoA reductase. (472 aa)
TTX_11024-hydroxybutyryl-CoA dehydratase. (498 aa)
TTX_1103CBS domain. (139 aa)
frdAFumarate reductase (succinate dehydrogenase/fumarate reductase), flavoprotein subunit. (581 aa)
frdBFumarate reductase (succinate dehydrogenase/fumarate reductase), iron-sulfur protein. (94 aa)
TTX_1106Succinic semialdehyde reductase. (363 aa)
pepC-1Phosphoenolpyruvate carboxylase 1. (457 aa)
acaB-3acetyl-CoA C-acyltransferase. (379 aa)
TTX_1112Predicted nucleic-acid-binding protein containing a Zn-ribbon. (116 aa)
acd-3acyl-CoA dehydrogenase. (405 aa)
acd-4acyl-CoA dehydrogenase. (382 aa)
acs-2acetyl-CoA synthetase 2. (666 aa)
gdhA-2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (425 aa)
TTX_11493-hydroxyisobutyrate dehydrogenase related enzyme. (284 aa)
gadGluconate dehydratase. (391 aa)
kdgA2-keto-3-deoxy-(6-phospho-) gluconate aldolase. (286 aa)
kdgK2-keto-3-deoxygluconate kinase. (310 aa)
gapNNon-phosphorylating glyceraldehyde-3-phosphate dehydrogenase, NAD(P) dependent. (501 aa)
nuoEFRespiratory chain oxidoreductase nuoE and nuoF subunits. (509 aa)
pfpPyrophosphate-dependent phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III s [...] (337 aa)
fbaFructose-bisphosphate aldolase archaeal type class I (FBP aldolase); Catalyzes the reversible cleavage of fructose 1,6- bisphosphate (FBP) to glyceraldehyde 3-phosphate (GAP) and dihydroxyacetone phosphate (DHAP). (263 aa)
fumCFumarate hydratase class II (fumarase). (445 aa)
glcBMalate synthase. (815 aa)
dldD-lactate dehydrogenase. (460 aa)
TTX_1318Fe-S oxidoreductases. (96 aa)
TTX_1319Fe-S oxidoreductase. (306 aa)
lctPL-lactate permease. (528 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (308 aa)
acs-3Acetyl-coenzyme A synthetase. (565 aa)
oorB-22-oxoacid ferredoxin oxidoreductase beta subunit. (302 aa)
oorCA2-oxoacid ferredoxin oxidoreductase, gamma-alpha subunit. (565 aa)
TTX_1479Predicted transcriptional regulator. (236 aa)
TTX_1488enoyl-CoA hydratase. (219 aa)
icdIsocitrate dehydrogenase. (439 aa)
prpDPropionate catabolism protein. (453 aa)
prpBCarboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (323 aa)
cis2Citrate synthase 2. (410 aa)
maeMalate dehydrogenase (malic enzyme). (434 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (NADP-dependent). (343 aa)
pgkPhosphoglycerate kinase. (327 aa)
TTX_1654Acyl-CoA synthetase (NDP forming). (464 aa)
adhPAlcohol dehydrogenase. (329 aa)
aspC-2Aspartate aminotransferase. (338 aa)
tktBTransketolase C-terminal section. (312 aa)
tktATransketolase N-terminal section. (250 aa)
oorB-32-oxoacid ferredoxin oxidoreductase, beta subunit. (315 aa)
oorCA-22-oxoacid ferredoxin oxidoreductase, gamma-alpha subunit. (635 aa)
acs-2-2acetyl-CoA synthetase 2. (668 aa)
fbpArchaeal fructose 1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (400 aa)
fumB/ttdBFumarate hydratase class I, C-terminal domain / tartrate dehydratase beta subunit; Unknown EC_number=4.2.1.2 / 4.2.1.32. (202 aa)
fumA/ttdAFumarate hydratase class I, N-terminal domain / tartrate dehydratase alpha subunit; Unknown EC_number=4.2.1.2 / 4.2.1.32. (289 aa)
oorC2-oxoacid ferredoxin oxidoreductase, gamma subunit. (185 aa)
oorD2-oxoacid ferredoxin oxidoreductase, delta subunit. (87 aa)
oorA-22-oxoacid ferredoxin oxidoreductase, alpha subunit. (383 aa)
oorB-42-oxoacid ferredoxin oxidoreductase, beta subunit. (307 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa)
nuoAPutative NADH-ubiquinone oxidoreductase chain A, subunit 3. (95 aa)
pepC-2Phosphoenolpyruvate carboxylase 2. (458 aa)
rbsKPutative ribokinase, sugar kinases ribokinase family; Belongs to the carbohydrate kinase PfkB family. (308 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (412 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (446 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (352 aa)
etfA-2Electron transfer flavoprotein alpha-subunit. (296 aa)
etfB-2Electron transfer flavoprotein beta-subunit. (258 aa)
acd-5acetyl-CoA synthetase. (233 aa)
TTX_2016succinyl-CoA synthetase alpha subunit. (468 aa)
TTX_2025Family M16 protease. (391 aa)
oorB-52-oxoacid ferredoxin oxidoreductase, beta subunit. (315 aa)
oorA-32-oxoacid ferredoxin oxidoreductase, alpha subunit. (396 aa)
oorD-22-oxoacid ferredoxin oxidoreductase, delta subunit. (102 aa)
oorC-22-oxoacid ferredoxin oxidoreductase, gamma subunit. (173 aa)
gorPutative ferredoxin-dependent glyceraldehyde-3-phosphate oxidoreductase. (625 aa)
rpiARibose 5-phosphate isomerase. (226 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (411 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (305 aa)
Your Current Organism:
Thermoproteus tenax
NCBI taxonomy Id: 768679
Other names: T. tenax Kra 1, Thermoproteus tenax DSM 2078, Thermoproteus tenax JCM 9277, Thermoproteus tenax Kra 1, Thermoproteus tenax str. Kra 1, Thermoproteus tenax strain Kra 1
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