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| | acs-3 | Acetyl-coenzyme A synthetase. (565 aa) |
| | atpB | H+-transporting A1A0 ATP synthase, subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (468 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (364 aa) |
| | dfp | Pantothenate metabolism flavoprotein; Unknown EC_number=4.1.1.36 6.3.2.5. (412 aa) |
| | pncB | Nicotinic acid phosphoribosyltransferase. (395 aa) |
| | moeA | Molybdenum cofactor biosynthesis protein. (411 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (334 aa) |
| | TTX_0542 | 5-formaminoimidazole-4-carboxamide-1-beta-D- ribofuranosyl 5'-monophosphate synthetase. (347 aa) |
| | TTX_0543 | 5-formaminoimidazole-4-carboxamide-1-beta-D- ribofuranosyl 5'-monophosphate synthetase. (335 aa) |
| | TTX_0546 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (169 aa) |
| | acs-4 | acetyl-CoA synthetase. (629 aa) |
| | acd | acyl-CoA dehydrogenase. (380 aa) |
| | thiI | Thiazole biosynthesis protein Thi I; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (472 aa) |
| | nadE1 | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (281 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (179 aa) |
| | moaD | Molybdopterin converting factor, small subunit. (89 aa) |
| | iorB | Indolepyruvate ferredoxin oxidoreductase, beta subunit. (181 aa) |
| | ydiS | Electron transfer flavoprotein-quinone oxidoreductase. (424 aa) |
| | moaDE | Molybdenum cofactor biosynthesis small amd large sunubits. (225 aa) |
| | atpD | A1A0 ATP synthase, subunit D, V-type. (200 aa) |
| | atpC | ATP synthase, subunit C, V-type. (349 aa) |
| | tmk | Thymidylate kinase. (196 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | pyrD | Dihydroorotate dehydrogenase. (297 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase. (199 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain. (304 aa) |
| | TTX_0829 | Putative nucleotidyltransferase. (150 aa) |
| | TTX_0860 | Diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (mutT/nudix family protein). (141 aa) |
| | TTX_0892 | Uncharacterized Rossmann fold enzyme. (205 aa) |
| | thyX | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (244 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | TTX_0999 | CMP/ AMP kinase related enzyme; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (191 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (288 aa) |
| | acd-2 | acyl-CoA dehydrogenase. (410 aa) |
| | FixC-2 | Dehydrogenase. (357 aa) |
| | TTX_1080 | Sugar kinase superfamily enzyme. (285 aa) |
| | TTX_1081 | Conserved hypothetical protein. (264 aa) |
| | apbA | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (279 aa) |
| | panB | 3-methyl-2-oxobutanoatehydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (265 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (628 aa) |
| | acd-4 | acyl-CoA dehydrogenase. (382 aa) |
| | acs-2 | acetyl-CoA synthetase 2. (666 aa) |
| | moeA-2 | moeA-like molybdenum cofactor biosynthesis domain fused to molybdate-binding domain. (639 aa) |
| | fdhD | Formate dehydrogenase delta subunit. (227 aa) |
| | TTX_1218 | Calcineurin-like phosphohydrolase. (98 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase. (84 aa) |
| | purK-2 | Phosphoribosylaminoimidazole carboxylase. (64 aa) |
| | nadE | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | TTX_1340 | P-loop ATPase superfamily protein. (288 aa) |
| | TTX_1345a | Thymidylate kinase family protein. (228 aa) |
| | TTX_1445 | NUDIX family hydrolase. (140 aa) |
| | oorCA | 2-oxoacid ferredoxin oxidoreductase, gamma-alpha subunit. (565 aa) |
| | folE | GTP cyclohydrolase I. (177 aa) |
| | ubiA-2 | Prenyltransferase family protein. (282 aa) |
| | TTX_1508 | Hypothetical protein. (190 aa) |
| | gldA | Glycerol-1-phosphate dehydrogenase GLPDH; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (344 aa) |
| | adkA | Adenylate kinase; Belongs to the archaeal adenylate kinase family. (197 aa) |
| | fixC | Dehydrogenase, FixC family. (316 aa) |
| | ino1 | Myo-inositol-1-phosphate synthase. (351 aa) |
| | carB | Carbamoyl-phosphate synthase, glutamine dependent, large chain; Belongs to the CarB family. (1018 aa) |
| | TTX_0077 | Metallo-beta-lactamase family protein. (260 aa) |
| | ilvB | Acetolactate synthase large subunit. (575 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (186 aa) |
| | TTX_0174 | Putative 3-hydroxy-3-methylglutaryl-CoA-synthase/3-oxoacyl-[acyl- carrier-protein] synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (349 aa) |
| | TTX_0183 | FixC-like dehydrogenase. (453 aa) |
| | TTX_0185 | Transcriptional regulator of a riboflavin/FAD biosynthetic operon. (212 aa) |
| | oorCD | 2-oxoacid ferredoxin oxidoreductase, gamma-delta subunit. (311 aa) |
| | modD | Putative pyrophosphorylase modD; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (272 aa) |
| | TTX_0263 | Hypothetical protein. (296 aa) |
| | purB | Adenylosuccinate lyase. (403 aa) |
| | thiC | Thiamine biosynthesis protein ThiC. (429 aa) |
| | snz1 | Pyridoxine biosynthesis enzyme; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (339 aa) |
| | pyrOB | Predicted glutamine amidotransferase involved in pyridoxine biosynthesis; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (279 aa) |
| | nadB | Aspartate oxidase. (463 aa) |
| | nadA | Quinolinate synthetase A. (304 aa) |
| | tdk | Thymidine kinase. (178 aa) |
| | nadM | Nicotinamide-nucleotide adenylyltransferase. (177 aa) |
| | TTX_1599 | Nicotinamide-nucleotide adenylyltransferase. (166 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B. (146 aa) |
| | moeA-3 | Molybdenum cofactor biosynthesis protein. (410 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (273 aa) |
| | TTX_1633 | Predicted GTPase. (440 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (219 aa) |
| | atpA | H+-transporting A1A0 ATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (593 aa) |
| | atpE | H+-transporting A1A0 ATP synthase subunit E. (186 aa) |
| | atpF | H+-transporting A1A0 ATP synthase subunit F, V-type. (96 aa) |
| | carS | CDP-diglyceride synthetase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (165 aa) |
| | TTX_1709 | Dehydrogenase (flavoprotein). (365 aa) |
| | TTX_1714 | Phosphate-binding enzyme, PcrB family, TIM-barrel fold; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (242 aa) |
| | gptA-1 | Xanthine-guanine phosphoribosyltransferase. (228 aa) |
| | TTX_1727 | Adenine/guanine phosphoribosyltransferase related PRPP-binding enzyme. (230 aa) |
| | tktB | Transketolase C-terminal section. (312 aa) |
| | tktA | Transketolase N-terminal section. (250 aa) |
| | oorB-3 | 2-oxoacid ferredoxin oxidoreductase, beta subunit. (315 aa) |
| | oorCA-2 | 2-oxoacid ferredoxin oxidoreductase, gamma-alpha subunit. (635 aa) |
| | acs-2-2 | acetyl-CoA synthetase 2. (668 aa) |
| | moaD-2 | Molybdopterin converting factor, small subunit. (100 aa) |
| | moaD-3 | Molybdopterin converting factor, small subunit. (94 aa) |
| | oorC | 2-oxoacid ferredoxin oxidoreductase, gamma subunit. (185 aa) |
| | oorD | 2-oxoacid ferredoxin oxidoreductase, delta subunit. (87 aa) |
| | TTX_1790 | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (117 aa) |
| | udp | Uridine phosphorylase. (256 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa) |
| | TTX_1820 | Putative phosphoribosyltransferase. (180 aa) |
| | TTX_1868 | Predicted nucleotide-utilizing enzyme, competence damage protein (cinA). (261 aa) |
| | TTX_1870 | Nucleotide kinase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (166 aa) |
| | cyaB | Adenylate cyclase. (173 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein. (85 aa) |
| | moaC-2 | Molybdenum cofactor biosynthesis protein C. (186 aa) |
| | moaA | Putative molybdopterin cofactor synthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (312 aa) |
| | pyrC | Dihydroorotase. (392 aa) |
| | purF | Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (417 aa) |
| | purF-2 | Amidophosphoribosyltransferase. (371 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (210 aa) |
| | purS | Phosphoribosylformylglycinamidine (FGAM) synthase. (86 aa) |
| | purD | Phosphoribosylamine--glycine ligase. (485 aa) |
| | purC | Phosphoribosylaminoimidazole- succinocarboxamidesynthase; Belongs to the SAICAR synthetase family. (233 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (307 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (317 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase. (277 aa) |
| | purK-3 | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (366 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (152 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (700 aa) |
| | cmk | Cytidylate kinase. (188 aa) |
| | oorD-2 | 2-oxoacid ferredoxin oxidoreductase, delta subunit. (102 aa) |
| | oorC-2 | 2-oxoacid ferredoxin oxidoreductase, gamma subunit. (173 aa) |
| | thiL | Thiamine monophosphate kinase. (284 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A. (266 aa) |
| | moaB | Molybdenum cofactor biosynthesis protein B. (174 aa) |
