STRINGSTRING
AFQ42127.1 AFQ42127.1 AFQ42263.1 AFQ42263.1 AFQ42643.1 AFQ42643.1 AFQ42821.1 AFQ42821.1 AFQ42890.1 AFQ42890.1 AFQ42972.1 AFQ42972.1 AFQ43045.1 AFQ43045.1 AFQ43046.1 AFQ43046.1 pckA pckA AFQ43582.1 AFQ43582.1 AFQ43720.1 AFQ43720.1 AFQ43765.1 AFQ43765.1 AFQ43881.1 AFQ43881.1 acsA acsA AFQ43920.1 AFQ43920.1 AFQ44006.1 AFQ44006.1 AFQ44401.1 AFQ44401.1 leuA leuA accA accA accD accD AFQ44859.1 AFQ44859.1 AFQ44909.1 AFQ44909.1 AFQ44915.1 AFQ44915.1 acsA-2 acsA-2 AFQ45043.1 AFQ45043.1 AFQ45044.1 AFQ45044.1 AFQ45061.1 AFQ45061.1 AFQ45106.1 AFQ45106.1 AFQ45109.1 AFQ45109.1 AFQ45414.1 AFQ45414.1 leuA-2 leuA-2 ackA ackA AFQ45656.1 AFQ45656.1 AFQ45695.1 AFQ45695.1 AFQ45809.1 AFQ45809.1 AFQ45841.1 AFQ45841.1 AFQ46027.1 AFQ46027.1 AFQ46067.1 AFQ46067.1 AFQ46068.1 AFQ46068.1 AFQ46190.1 AFQ46190.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AFQ42127.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. (1176 aa)
AFQ42263.1PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (418 aa)
AFQ42643.1Lactoylglutathione lyase-like lyase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily. (126 aa)
AFQ42821.1PFAM: Uncharacterized conserved protein (DUF2088). (427 aa)
AFQ42890.1acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
AFQ42972.1Zn-dependent hydrolase, glyoxylase; PFAM: Metallo-beta-lactamase superfamily. (206 aa)
AFQ43045.1PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein. (629 aa)
AFQ43046.1acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
pckAATP-dependent phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (524 aa)
AFQ43582.1PFAM: Aldehyde dehydrogenase family; TIGRFAM: acetaldehyde dehydrogenase (acetylating). (503 aa)
AFQ43720.1PFAM: Aldehyde dehydrogenase family; TIGRFAM: acetaldehyde dehydrogenase (acetylating). (503 aa)
AFQ43765.1Acyl CoA:acetate/3-ketoacid CoA transferase; PFAM: Coenzyme A transferase; Belongs to the 3-oxoacid CoA-transferase family. (518 aa)
AFQ43881.1Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. (465 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (773 aa)
AFQ43920.1Lactoylglutathione lyase-like lyase. (120 aa)
AFQ44006.1PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (578 aa)
AFQ44401.1PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (576 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (506 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (328 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (305 aa)
AFQ44859.1Phosphotransacetylase; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase. (323 aa)
AFQ44909.1acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AFQ44915.1PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (376 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (750 aa)
AFQ45043.12-oxoacid:ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (268 aa)
AFQ45044.12-oxoacid:ferredoxin oxidoreductase, alpha subunit; PFAM: domain. (373 aa)
AFQ45061.1TIGRFAM: lactoylglutathione lyase. (122 aa)
AFQ45106.1acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family. (452 aa)
AFQ45109.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
AFQ45414.1Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: domain; Domain of unknown function; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric. (1175 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (510 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
AFQ45656.1Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (192 aa)
AFQ45695.1Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. (460 aa)
AFQ45809.1Pyruvate phosphate dikinase; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (884 aa)
AFQ45841.1PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (371 aa)
AFQ46027.1PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (531 aa)
AFQ46067.1PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region. (185 aa)
AFQ46068.1PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region. (286 aa)
AFQ46190.1PFAM: Aldehyde dehydrogenase family; TIGRFAM: acetaldehyde dehydrogenase (acetylating). (494 aa)
Your Current Organism:
Desulfosporosinus meridiei
NCBI taxonomy Id: 768704
Other names: D. meridiei DSM 13257, Desulfosporosinus meridiei DSM 13257, Desulfosporosinus meridiei str. DSM 13257, Desulfosporosinus meridiei strain DSM 13257, Desulfosporosinus sp. S10
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