STRINGSTRING
AFQ42278.1 AFQ42278.1 AFQ42496.1 AFQ42496.1 AFQ42497.1 AFQ42497.1 AFQ42498.1 AFQ42498.1 AFQ42505.1 AFQ42505.1 AFQ42618.1 AFQ42618.1 AFQ42745.1 AFQ42745.1 pfkA pfkA serC serC AFQ42918.1 AFQ42918.1 AFQ43268.1 AFQ43268.1 AFQ43343.1 AFQ43343.1 AFQ43529.1 AFQ43529.1 AFQ43530.1 AFQ43530.1 AFQ43531.1 AFQ43531.1 AFQ43595.1 AFQ43595.1 AFQ43640.1 AFQ43640.1 AFQ43757.1 AFQ43757.1 AFQ43758.1 AFQ43758.1 acsA acsA AFQ44143.1 AFQ44143.1 AFQ44160.1 AFQ44160.1 AFQ44161.1 AFQ44161.1 AFQ44162.1 AFQ44162.1 AFQ44279.1 AFQ44279.1 AFQ44448.1 AFQ44448.1 AFQ44451.1 AFQ44451.1 AFQ44453.1 AFQ44453.1 AFQ44526.1 AFQ44526.1 AFQ44530.1 AFQ44530.1 pfkA-2 pfkA-2 AFQ44859.1 AFQ44859.1 AFQ44885.1 AFQ44885.1 mch mch acsA-2 acsA-2 AFQ45089.1 AFQ45089.1 AFQ45172.1 AFQ45172.1 AFQ45173.1 AFQ45173.1 AFQ45175.1 AFQ45175.1 AFQ45227.1 AFQ45227.1 AFQ45325.1 AFQ45325.1 ackA ackA comB comB AFQ45878.1 AFQ45878.1 AFQ45879.1 AFQ45879.1 AFQ46034.1 AFQ46034.1 AFQ46209.1 AFQ46209.1 eno eno gpmI gpmI glyA glyA AFQ46382.1 AFQ46382.1 AFQ46384.1 AFQ46384.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFQ42278.1NAD-dependent formate dehydrogenase catalytic subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; 4Fe-4S binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (893 aa)
AFQ42496.1PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H. (306 aa)
AFQ42497.1PFAM: Trimethylamine methyltransferase (MTTB); Belongs to the trimethylamine methyltransferase family. (470 aa)
AFQ42498.1PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. (215 aa)
AFQ42505.1PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (638 aa)
AFQ42618.1PFAM: Prokaryotic dksA/traR C4-type zinc finger; FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (176 aa)
AFQ42745.1NAD-dependent formate dehydrogenase catalytic subunit; PFAM: Molybdopterin oxidoreductase; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type; Contains selenocysteine; manually curated. (893 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (359 aa)
serCPhosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
AFQ42918.1Phosphoglycerate dehydrogenase-like oxidoreductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. (387 aa)
AFQ43268.1Fe-S-cluster-containing hydrogenase subunit; PFAM: 4Fe-4S binding domain. (258 aa)
AFQ43343.1Theronine dehydrogenase-like Zn-dependent dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase. (381 aa)
AFQ43529.1Formate dehydrogenase, alpha subunit; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, proteobacterial-type; Tat (twin-arginine translocation) pathway signal sequence; Contains selenocysteine; manually curated; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1011 aa)
AFQ43530.1Fe-S-cluster-containing hydrogenase subunit; PFAM: 4Fe-4S binding domain; Formate dehydrogenase N, transmembrane; TIGRFAM: formate dehydrogenase, beta subunit, Fe-S containing. (260 aa)
AFQ43531.1PFAM: Cytochrome b(N-terminal)/b6/petB; TIGRFAM: formate dehydrogenase, gamma subunit. (233 aa)
AFQ43595.1PFAM: Trimethylamine methyltransferase (MTTB). (480 aa)
AFQ43640.1PFAM: Trimethylamine methyltransferase (MTTB); Belongs to the trimethylamine methyltransferase family. (474 aa)
AFQ43757.1PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (635 aa)
AFQ43758.1Fe-S-cluster-containing hydrogenase subunit; PFAM: 4Fe-4S binding domain. (164 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (773 aa)
AFQ44143.1PFAM: Methanol-cobalamin methyltransferase B subunit. (466 aa)
AFQ44160.1PFAM: Pyridine nucleotide-disulphide oxidoreductase; FAD binding domain; 4Fe-4S binding domain. (1010 aa)
AFQ44161.1PFAM: Methyl-viologen-reducing hydrogenase, delta subunit. (157 aa)
AFQ44162.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (316 aa)
AFQ44279.1PFAM: Trimethylamine methyltransferase (MTTB); Belongs to the trimethylamine methyltransferase family. (468 aa)
AFQ44448.1PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase, delta subunit. (320 aa)
AFQ44451.1PFAM: Putative Fe-S cluster; CO dehydrogenase/acetyl-CoA synthase delta subunit. (441 aa)
AFQ44453.1acetyl-CoA decarbonylase/synthase alpha subunit; PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (672 aa)
AFQ44526.1Fructose-2,6-bisphosphatase; PFAM: Phosphoglycerate mutase family; Belongs to the phosphoglycerate mutase family. (206 aa)
AFQ44530.1PFAM: FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (144 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
AFQ44859.1Phosphotransacetylase; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase. (323 aa)
AFQ44885.1PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. (219 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (322 aa)
acsA-2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (750 aa)
AFQ45089.1PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (654 aa)
AFQ45172.1PFAM: Uroporphyrinogen decarboxylase (URO-D); TIGRFAM: methyltransferase, MtaA/CmuA family; Belongs to the uroporphyrinogen decarboxylase family. (338 aa)
AFQ45173.1Putative cobalamin binding protein; PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. (219 aa)
AFQ45175.1PFAM: Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (292 aa)
AFQ45227.1PFAM: Serine hydroxymethyltransferase. (409 aa)
AFQ45325.16Fe-6S prismane cluster-containing protein; PFAM: Prismane/CO dehydrogenase family; TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit. (676 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
comBPhosphosulfolactate phosphohydrolase-like enzyme; PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (243 aa)
AFQ45878.1PFAM: Trimethylamine methyltransferase (MTTB). (485 aa)
AFQ45879.1PFAM: Trimethylamine methyltransferase (MTTB). (494 aa)
AFQ46034.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (472 aa)
AFQ46209.1PFAM: Conserved region in glutamate synthase; Belongs to the glutamate synthase family. (467 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
glyAGlycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
AFQ46382.1Fructose-1,6-bisphosphatase, class II; PFAM: Bacterial fructose-1,6-bisphosphatase, glpX-encoded; TIGRFAM: fructose-1,6-bisphosphatase, class II. (323 aa)
AFQ46384.1PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist. (284 aa)
Your Current Organism:
Desulfosporosinus meridiei
NCBI taxonomy Id: 768704
Other names: D. meridiei DSM 13257, Desulfosporosinus meridiei DSM 13257, Desulfosporosinus meridiei str. DSM 13257, Desulfosporosinus meridiei strain DSM 13257, Desulfosporosinus sp. S10
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