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Malapachy_2067 Malapachy_2067 Malapachy_1336 Malapachy_1336 Malapachy_2969 Malapachy_2969 Malapachy_3825 Malapachy_3825 Malapachy_3772 Malapachy_3772 Malapachy_0089 Malapachy_0089 Malapachy_0435 Malapachy_0435 Malapachy_2795 Malapachy_2795 Malapachy_1539 Malapachy_1539 Malapachy_1280 Malapachy_1280 Malapachy_1544 Malapachy_1544 Malapachy_0667 Malapachy_0667 Malapachy_3138 Malapachy_3138 Malapachy_0861 Malapachy_0861 Malapachy_0564 Malapachy_0564 Malapachy_3942 Malapachy_3942 Malapachy_1089 Malapachy_1089 Malapachy_0423 Malapachy_0423 Malapachy_2820 Malapachy_2820 Malapachy_2266 Malapachy_2266 Malapachy_0970 Malapachy_0970 Malapachy_3490 Malapachy_3490 Malapachy_3444 Malapachy_3444 Malapachy_3248 Malapachy_3248 Malapachy_3460 Malapachy_3460 Malapachy_1279 Malapachy_1279 Malapachy_3955 Malapachy_3955 Malapachy_1103 Malapachy_1103 Malapachy_0948 Malapachy_0948 Malapachy_3083 Malapachy_3083
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Malapachy_2067Histidine biosynthesis trifunctional protein. (883 aa)
Malapachy_1336NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (247 aa)
Malapachy_2969NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (509 aa)
Malapachy_3825ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (309 aa)
Malapachy_3772Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (707 aa)
Malapachy_0089S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (384 aa)
Malapachy_0435Nadh-ubiquinone oxidoreductase; Belongs to the complex I 49 kDa subunit family. (459 aa)
Malapachy_2795Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family. (386 aa)
Malapachy_1539D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (489 aa)
Malapachy_1280Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (536 aa)
Malapachy_1544NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1043 aa)
Malapachy_0667tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. (760 aa)
Malapachy_3138Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (359 aa)
Malapachy_0861Nadh-ubiquinone oxidoreductase 20 kDa subunit; Belongs to the complex I 20 kDa subunit family. (215 aa)
Malapachy_0564Nadh-ubiquinone oxidoreductase; Belongs to the complex I 30 kDa subunit family. (280 aa)
Malapachy_3942Glycerol-3-phosphate dehydrogenase [NAD(+)]. (347 aa)
Malapachy_1089UDP-glucose 6-dehydrogenase. (471 aa)
Malapachy_0423Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (348 aa)
Malapachy_2820NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (276 aa)
Malapachy_2266NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (339 aa)
Malapachy_0970Adenosylhomocysteinase. (433 aa)
Malapachy_3490Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (548 aa)
Malapachy_3444Dihydrolipoyl dehydrogenase. (504 aa)
Malapachy_3248UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (367 aa)
Malapachy_3460Glyceraldehyde-3-phosphate dehydrogenase. (336 aa)
Malapachy_1279NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (747 aa)
Malapachy_39553-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (378 aa)
Malapachy_11033-hydroxyacyl-dehydrogenase. (330 aa)
Malapachy_0948Cyc2-cytochrome-c mitochondrial import factor. (183 aa)
Malapachy_3083Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (552 aa)
Your Current Organism:
Malassezia pachydermatis
NCBI taxonomy Id: 77020
Other names: M. pachydermatis, Pityrosporum pachydermatis
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