node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
D910_01503 | D910_12347 | N6UJ54 | U4UPP0 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.445 |
D910_04373 | D910_06590 | U4UAI6 | U4UF40 | E3 ubiquitin-protein ligase. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | 0.645 |
D910_04373 | D910_12347 | U4UAI6 | U4UPP0 | E3 ubiquitin-protein ligase. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.587 |
D910_05041 | D910_12347 | U4UCH5 | U4UPP0 | Arrestin_C domain-containing protein. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.842 |
D910_06084 | D910_08690 | J3JTI8 | N6TUG3 | Arrestin_C domain-containing protein. | Arrestin_C domain-containing protein. | 0.862 |
D910_06084 | D910_12347 | J3JTI8 | U4UPP0 | Arrestin_C domain-containing protein. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.842 |
D910_06590 | D910_04373 | U4UF40 | U4UAI6 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | E3 ubiquitin-protein ligase. | 0.645 |
D910_06590 | D910_10002 | U4UF40 | N6TD39 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | Uncharacterized protein. | 0.596 |
D910_06590 | D910_10003 | U4UF40 | N6U987 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | HECT domain-containing protein. | 0.596 |
D910_06590 | D910_12347 | U4UF40 | U4UPP0 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.950 |
D910_08690 | D910_06084 | N6TUG3 | J3JTI8 | Arrestin_C domain-containing protein. | Arrestin_C domain-containing protein. | 0.862 |
D910_08690 | D910_12066 | N6TUG3 | U4UNV4 | Arrestin_C domain-containing protein. | Arrestin_C domain-containing protein. | 0.455 |
D910_08690 | D910_12347 | N6TUG3 | U4UPP0 | Arrestin_C domain-containing protein. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.844 |
D910_10002 | D910_06590 | N6TD39 | U4UF40 | Uncharacterized protein. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | 0.596 |
D910_10002 | D910_10003 | N6TD39 | N6U987 | Uncharacterized protein. | HECT domain-containing protein. | 0.917 |
D910_10002 | D910_12347 | N6TD39 | U4UPP0 | Uncharacterized protein. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.575 |
D910_10003 | D910_06590 | N6U987 | U4UF40 | HECT domain-containing protein. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. | 0.596 |
D910_10003 | D910_10002 | N6U987 | N6TD39 | HECT domain-containing protein. | Uncharacterized protein. | 0.917 |
D910_10003 | D910_12347 | N6U987 | U4UPP0 | HECT domain-containing protein. | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. | 0.575 |
D910_12066 | D910_08690 | U4UNV4 | N6TUG3 | Arrestin_C domain-containing protein. | Arrestin_C domain-containing protein. | 0.455 |