42 items (Dendroctonus ponderosae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D910_04494	Uncharacterized protein. (475 aa)
	D910_00641	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (561 aa)
	D910_04783	Uncharacterized protein. (379 aa)
	D910_03863	PX domain-containing protein. (167 aa)
	D910_03895	PX domain-containing protein. (415 aa)
	D910_07986	Fmp27_GFWDK domain-containing protein. (1454 aa)
	D910_08140	Uncharacterized protein. (405 aa)
	D910_04318	Uncharacterized protein. (361 aa)
	D910_05659	Peptidase M12B domain-containing protein. (695 aa)
	D910_07876	Uncharacterized protein. (490 aa)
	D910_06590	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (659 aa)
	D910_09976	Uncharacterized protein; Belongs to the AAA ATPase family. (180 aa)
	D910_06761	Uncharacterized protein. (295 aa)
	D910_09895	Flot domain-containing protein; Belongs to the band 7/mec-2 family. Flotillin subfamily. (285 aa)
	D910_09935	Uncharacterized protein. (756 aa)
	D910_06945	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (929 aa)
	D910_08490	tRNA-binding domain-containing protein. (313 aa)
	D910_11937	Uncharacterized protein. (2377 aa)
	D910_12829	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (716 aa)
	D910_10566	Uncharacterized protein. (1083 aa)
	D910_09322	Uncharacterized protein. (489 aa)
	D910_11938	Uncharacterized protein. (254 aa)
	D910_12367	Uncharacterized protein. (1015 aa)
	D910_10894	Uncharacterized protein. (506 aa)
	D910_11250	Pep3_Vps18 domain-containing protein. (947 aa)
	D910_01998	Uncharacterized protein. (1326 aa)
	D910_07988	Uncharacterized protein. (253 aa)
	D910_04642	Uncharacterized protein. (321 aa)
	D910_03488	Uncharacterized protein. (543 aa)
	D910_10857	Uncharacterized protein. (1669 aa)
	D910_08377	BHLH domain-containing protein. (150 aa)
	D910_11178	Uncharacterized protein. (210 aa)
	D910_01971	Uncharacterized protein. (72 aa)
	D910_05064	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1218 aa)
	D910_07874	Uncharacterized protein. (318 aa)
	D910_00401	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (810 aa)
	D910_03187	Uncharacterized protein. (287 aa)
	D910_02872	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family. (682 aa)
	D910_10216	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (148 aa)
	D910_02577	Uncharacterized protein. (239 aa)
	D910_01542	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (776 aa)
	D910_10896	Uncharacterized protein. (470 aa)

Your Current Organism:

Dendroctonus ponderosae

NCBI taxonomy Id: 77166
Other names: D. ponderosae, mountain pine beetle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D910_00401	D910_10566	U4TRT6	U4UT33	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.984
D910_01542	D910_10566	J3JX23	U4UT33	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	Uncharacterized protein.	0.997
D910_02872	D910_03863	U4TZK6	U4U778	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	PX domain-containing protein.	0.566
D910_02872	D910_03895	U4TZK6	U4U7A6	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	PX domain-containing protein.	0.519
D910_02872	D910_06945	U4TZK6	U4UI68	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.679
D910_03488	D910_03863	N6TS54	U4U778	Uncharacterized protein.	PX domain-containing protein.	0.921
D910_03488	D910_06945	N6TS54	U4UI68	Uncharacterized protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.842
D910_03863	D910_02872	U4U778	U4TZK6	PX domain-containing protein.	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	0.566
D910_03863	D910_03488	U4U778	N6TS54	PX domain-containing protein.	Uncharacterized protein.	0.921
D910_03863	D910_03895	U4U778	U4U7A6	PX domain-containing protein.	PX domain-containing protein.	0.675
D910_03863	D910_06590	U4U778	U4UF40	PX domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.752
D910_03863	D910_06945	U4U778	U4UI68	PX domain-containing protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.992
D910_03895	D910_02872	U4U7A6	U4TZK6	PX domain-containing protein.	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	0.519
D910_03895	D910_03863	U4U7A6	U4U778	PX domain-containing protein.	PX domain-containing protein.	0.675
D910_03895	D910_06945	U4U7A6	U4UI68	PX domain-containing protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.883
D910_06590	D910_03863	U4UF40	U4U778	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	PX domain-containing protein.	0.752
D910_06590	D910_06945	U4UF40	U4UI68	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.672
D910_06590	D910_09976	U4UF40	U4UFB0	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.544
D910_06590	D910_10857	U4UF40	N6U701	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	Uncharacterized protein.	0.759
D910_06945	D910_02872	U4UI68	U4TZK6	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	PX domain-containing protein; Belongs to the tetraspanin (TM4SF) family.	0.679