96 items (Dendroctonus ponderosae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	D910_08742	Uncharacterized protein. (212 aa)
	D910_05695	BRO1 domain-containing protein. (824 aa)
	D910_07340	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	D910_09371	Uncharacterized protein. (223 aa)
	D910_02372	Uncharacterized protein. (215 aa)
	D910_05483	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (288 aa)
	D910_10140	Uncharacterized protein. (206 aa)
	D910_07727	Uncharacterized protein; Belongs to the heat shock protein 70 family. (639 aa)
	D910_11491	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	D910_07890	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (252 aa)
	D910_03638	Uncharacterized protein. (220 aa)
	D910_00798	Uncharacterized protein. (207 aa)
	D910_03001	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (438 aa)
	D910_03047	GLUE N-terminal domain-containing protein. (391 aa)
	D910_06695	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (177 aa)
	D910_09903	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (374 aa)
	D910_01304	Uncharacterized protein. (316 aa)
	D910_09617	PX domain-containing protein. (485 aa)
	D910_08046	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	D910_12202	Uncharacterized protein. (288 aa)
	D910_10968	Uncharacterized protein. (412 aa)
	D910_11495	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (532 aa)
	D910_11505	Uncharacterized protein. (852 aa)
	D910_07726	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	D910_00332	Uncharacterized protein. (219 aa)
	D910_07647	Uncharacterized protein. (289 aa)
	D910_05303	Uncharacterized protein. (391 aa)
	D910_02994	Uncharacterized protein. (336 aa)
	D910_11633	Uncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
	D910_04770	Uncharacterized protein. (275 aa)
	D910_06088	Uncharacterized protein. (191 aa)
	D910_11552	Alpha_adaptinC2 domain-containing protein. (937 aa)
	D910_06982	Uncharacterized protein. (203 aa)
	D910_10471	Uncharacterized protein. (331 aa)
	D910_05101	Uncharacterized protein. (300 aa)
	D910_07635	Uncharacterized protein. (168 aa)
	D910_06941	PIPK domain-containing protein. (522 aa)
	D910_04698	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (550 aa)
	D910_06141	Uncharacterized protein; Belongs to the VPS28 family. (214 aa)
	D910_02124	Uncharacterized protein. (212 aa)
	D910_02120	MRP-S23 domain-containing protein. (471 aa)
	D910_03197	FYVE-type domain-containing protein. (778 aa)
	D910_03421	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (562 aa)
	D910_04267	Uncharacterized protein. (579 aa)
	D910_03859	MPN domain-containing protein. (360 aa)
	D910_03128	Uncharacterized protein. (1581 aa)
	D910_03373	FYVE-type domain-containing protein. (635 aa)
	D910_05040	Uncharacterized protein. (143 aa)
	D910_05691	PX domain-containing protein. (558 aa)
	D910_04236	Uncharacterized protein. (80 aa)
	D910_05052	Uncharacterized protein; Belongs to the heat shock protein 70 family. (636 aa)
	D910_02647	Uncharacterized protein. (385 aa)
	D910_05250	Uncharacterized protein. (217 aa)
	D910_02249	Senescence domain-containing protein. (542 aa)
	D910_03863	PX domain-containing protein. (167 aa)
	D910_03895	PX domain-containing protein. (415 aa)
	D910_04334	Uncharacterized protein; Belongs to the heat shock protein 70 family. (623 aa)
	D910_07070	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (476 aa)
	D910_07946	WH2 domain-containing protein. (156 aa)
	D910_00516	Uncharacterized protein. (2294 aa)
	D910_04932	Uncharacterized protein. (1152 aa)
	D910_04373	E3 ubiquitin-protein ligase. (858 aa)
	D910_07008	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1328 aa)
	D910_08651	Uncharacterized protein. (915 aa)
	D910_05390	Uncharacterized protein. (250 aa)
	D910_08261	Uncharacterized protein. (177 aa)
	D910_07757	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
	D910_06590	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (659 aa)
	D910_09976	Uncharacterized protein; Belongs to the AAA ATPase family. (180 aa)
	D910_08863	Uncharacterized protein. (347 aa)
	D910_08963	Uncharacterized protein. (808 aa)
	D910_06554	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (379 aa)
	D910_09736	MH2 domain-containing protein. (157 aa)
	D910_09850	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (860 aa)
	D910_09870	VPS37 C-terminal domain-containing protein. (236 aa)
	D910_10027	Uncharacterized protein. (768 aa)
	D910_06945	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (929 aa)
	D910_09390	Uncharacterized protein. (653 aa)
	D910_10100	Uncharacterized protein. (365 aa)
	D910_11205	Uncharacterized protein. (214 aa)
	D910_09650	Uncharacterized protein. (189 aa)
	D910_07724	Uncharacterized protein. (478 aa)
	D910_10305	SEC7 domain-containing protein. (1695 aa)
	D910_10636	Uncharacterized protein. (381 aa)
	D910_11917	FIP-RBD domain-containing protein. (492 aa)
	D910_12066	Arrestin_C domain-containing protein. (252 aa)
	D910_11465	SEC7 domain-containing protein. (1699 aa)
	D910_12347	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1715 aa)
	D910_01171	WH2 domain-containing protein. (444 aa)
	D910_09505	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (786 aa)
	D910_00083	Uncharacterized protein. (239 aa)
	D910_11162	Uncharacterized protein. (427 aa)
	D910_11281	Arf-GAP domain-containing protein. (506 aa)
	D910_11660	Uncharacterized protein. (943 aa)
	D910_12807	SEC7 domain-containing protein. (848 aa)
	D910_00721	WH1 domain-containing protein. (105 aa)

Your Current Organism:

Dendroctonus ponderosae

NCBI taxonomy Id: 77166
Other names: D. ponderosae, mountain pine beetle

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D910_00083	D910_00516	U4UT05	U4UA05	Uncharacterized protein.	Uncharacterized protein.	0.900
D910_00083	D910_02647	U4UT05	U4U3Q1	Uncharacterized protein.	Uncharacterized protein.	0.935
D910_00083	D910_03001	U4UT05	J3JY16	Uncharacterized protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.607
D910_00083	D910_04236	U4UT05	U4U3F1	Uncharacterized protein.	Uncharacterized protein.	0.900
D910_00083	D910_04373	U4UT05	U4UAI6	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.921
D910_00083	D910_04770	U4UT05	N6TWI3	Uncharacterized protein.	Uncharacterized protein.	0.629
D910_00083	D910_06590	U4UT05	U4UF40	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.595
D910_00083	D910_08651	U4UT05	U4UBL1	Uncharacterized protein.	Uncharacterized protein.	0.659
D910_00083	D910_10471	U4UT05	N6U6K8	Uncharacterized protein.	Uncharacterized protein.	0.800
D910_00083	D910_10968	U4UT05	N6T883	Uncharacterized protein.	Uncharacterized protein.	0.930
D910_00083	D910_12347	U4UT05	U4UPP0	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.573
D910_00332	D910_02124	N6TGA5	U4TT48	Uncharacterized protein.	Uncharacterized protein.	0.987
D910_00332	D910_03047	N6TGA5	J3JYD3	Uncharacterized protein.	GLUE N-terminal domain-containing protein.	0.896
D910_00332	D910_03638	N6TGA5	J3JXU3	Uncharacterized protein.	Uncharacterized protein.	0.997
D910_00332	D910_03859	N6TGA5	U4U056	Uncharacterized protein.	MPN domain-containing protein.	0.887
D910_00332	D910_05303	N6TGA5	N6TTI4	Uncharacterized protein.	Uncharacterized protein.	0.898
D910_00332	D910_05390	N6TGA5	U4UBM3	Uncharacterized protein.	Uncharacterized protein.	0.997
D910_00332	D910_05695	N6TGA5	J3JTI1	Uncharacterized protein.	BRO1 domain-containing protein.	0.689
D910_00332	D910_06141	N6TGA5	N6UMU8	Uncharacterized protein.	Uncharacterized protein; Belongs to the VPS28 family.	0.909
D910_00332	D910_06590	N6TGA5	U4UF40	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.733