STRINGSTRING
SMAC_09309 SMAC_09309 SMAC_00145 SMAC_00145 SMAC_00239 SMAC_00239 SMAC_00470 SMAC_00470 SMAC_00501 SMAC_00501 SMAC_04808 SMAC_04808 SMAC_04883 SMAC_04883 SMAC_00713 SMAC_00713 SMAC_00862 SMAC_00862 SMAC_00907 SMAC_00907 SMAC_00995 SMAC_00995 SMAC_01050 SMAC_01050 ADK1 ADK1 SMAC_02405 SMAC_02405 SMAC_01524 SMAC_01524 SMAC_01578 SMAC_01578 SMAC_01579 SMAC_01579 SMAC_01580 SMAC_01580 SMAC_01617 SMAC_01617 SMAC_01662 SMAC_01662 SMAC_05730 SMAC_05730 SMAC_05995 SMAC_05995 SMAC_07513 SMAC_07513 SMAC_04987 SMAC_04987 SMAC_05191 SMAC_05191 SMAC_03713 SMAC_03713 SMAC_02848 SMAC_02848 SMAC_02892 SMAC_02892 SMAC_02914 SMAC_02914 ADK2 ADK2 SMAC_06675 SMAC_06675 SMAC_08849 SMAC_08849 SMAC_04510 SMAC_04510 SMAC_04509 SMAC_04509 SMAC_04392 SMAC_04392 SMAC_04380 SMAC_04380 SMAC_03769 SMAC_03769 SMAC_03806 SMAC_03806 SMAC_03945 SMAC_03945 SMAC_03946 SMAC_03946 SMAC_04026 SMAC_04026 SMAC_02161 SMAC_02161 SMAC_04237 SMAC_04237 SMAC_04291 SMAC_04291 SMAC_04522 SMAC_04522 SMAC_04523 SMAC_04523 SMAC_05071 SMAC_05071 SMAC_02188 SMAC_02188 SMAC_02248 SMAC_02248 SMAC_02272 SMAC_02272 SMAC_05360 SMAC_05360 SMAC_06538 SMAC_06538 SMAC_07909 SMAC_07909 SMAC_05698 SMAC_05698 SMAC_07643 SMAC_07643 SMAC_06300 SMAC_06300 SMAC_06582 SMAC_06582 SMAC_06905 SMAC_06905 SMAC_07771 SMAC_07771 SMAC_09143 SMAC_09143 SMAC_09145 SMAC_09145 SMAC_09146 SMAC_09146 SMAC_07753 SMAC_07753 SMAC_07976 SMAC_07976 SMAC_08524 SMAC_08524 SMAC_09108 SMAC_09108 SMAC_09163 SMAC_09163 SMAC_10080 SMAC_10080 SMAC_10630 SMAC_10630
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAC_09309Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (430 aa)
SMAC_00145WGS project CABT00000000 data, contig 2.1; Belongs to the dihydrofolate reductase family. (223 aa)
SMAC_00239WGS project CABT00000000 data, contig 2.1. (386 aa)
SMAC_00470WGS project CABT00000000 data, contig 2.1. (1023 aa)
SMAC_00501WGS project CABT00000000 data, contig 2.1. (205 aa)
SMAC_04808WGS project CABT00000000 data, contig 2.1. (306 aa)
SMAC_04883WGS project CABT00000000 data, contig 2.1. (180 aa)
SMAC_00713WGS project CABT00000000 data, contig 2.2. (506 aa)
SMAC_00862Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (568 aa)
SMAC_00907WGS project CABT00000000 data, contig 2.2. (302 aa)
SMAC_00995WGS project CABT00000000 data, contig 2.2. (263 aa)
SMAC_01050WGS project CABT00000000 data, contig 2.2. (194 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (278 aa)
SMAC_02405WGS project CABT00000000 data, contig 2.3. (384 aa)
SMAC_01524WGS project CABT00000000 data, contig 2.4. (232 aa)
SMAC_01578Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (497 aa)
SMAC_01579WGS project CABT00000000 data, contig 2.4. (204 aa)
SMAC_01580WGS project CABT00000000 data, contig 2.4. (188 aa)
SMAC_01617WGS project CABT00000000 data, contig 2.4. (680 aa)
SMAC_01662WGS project CABT00000000 data, contig 2.5. (477 aa)
SMAC_05730WGS project CABT00000000 data, contig 2.6. (594 aa)
SMAC_05995Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1071 aa)
SMAC_07513WGS project CABT00000000 data, contig 2.7. (645 aa)
SMAC_04987WGS project CABT00000000 data, contig 2.8. (226 aa)
SMAC_05191WGS project CABT00000000 data, contig 2.8. (250 aa)
SMAC_03713Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (480 aa)
SMAC_02848Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (536 aa)
SMAC_02892WGS project CABT00000000 data, contig 2.12. (378 aa)
SMAC_02914Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (631 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (273 aa)
SMAC_06675CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (579 aa)
SMAC_08849WGS project CABT00000000 data, contig 2.13. (348 aa)
SMAC_04510Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
SMAC_04509Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (175 aa)
SMAC_04392Nucleoside diphosphate kinase. (152 aa)
SMAC_04380Amidophosphoribosyltransferase. (546 aa)
SMAC_03769WGS project CABT00000000 data, contig 2.16. (1357 aa)
SMAC_03806WGS project CABT00000000 data, contig 2.16; Belongs to the GDA1/CD39 NTPase family. (750 aa)
SMAC_03945WGS project CABT00000000 data, contig 2.17. (508 aa)
SMAC_03946WGS project CABT00000000 data, contig 2.17. (330 aa)
SMAC_04026Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (424 aa)
SMAC_02161WGS project CABT00000000 data, contig 2.18. (410 aa)
SMAC_042376,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (203 aa)
SMAC_04291Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (466 aa)
SMAC_04522WGS project CABT00000000 data, contig 2.20. (435 aa)
SMAC_04523WGS project CABT00000000 data, contig 2.20. (689 aa)
SMAC_05071WGS project CABT00000000 data, contig 2.22. (409 aa)
SMAC_02188WGS project CABT00000000 data, contig 2.23. (446 aa)
SMAC_02248WGS project CABT00000000 data, contig 2.23. (762 aa)
SMAC_02272WGS project CABT00000000 data, contig 2.23. (1418 aa)
SMAC_05360Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa)
SMAC_06538WGS project CABT00000000 data, contig 2.28. (363 aa)
SMAC_079093,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (235 aa)
SMAC_05698WGS project CABT00000000 data, contig 2.30. (353 aa)
SMAC_07643Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (550 aa)
SMAC_06300WGS project CABT00000000 data, contig 2.34. (1150 aa)
SMAC_06582Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (772 aa)
SMAC_06905WGS project CABT00000000 data, contig 2.38. (378 aa)
SMAC_07771Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (937 aa)
SMAC_09143WGS project CABT00000000 data, contig 2.43. (319 aa)
SMAC_09145WGS project CABT00000000 data, contig 2.43. (279 aa)
SMAC_09146WGS project CABT00000000 data, contig 2.43. (425 aa)
SMAC_07753WGS project CABT00000000 data, contig 2.47; Belongs to the adenylate kinase family. (561 aa)
SMAC_07976Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (169 aa)
SMAC_08524WGS project CABT00000000 data, contig 2.54. (286 aa)
SMAC_09108WGS project CABT00000000 data, contig 2.72. (297 aa)
SMAC_09163WGS project CABT00000000 data, contig 2.74. (520 aa)
SMAC_10080WGS project CABT00000000 data, contig 2.323. (301 aa)
SMAC_10630WGS project CABT00000000 data, contig 2.468. (173 aa)
Your Current Organism:
Sordaria macrospora
NCBI taxonomy Id: 771870
Other names: S. macrospora k-hell, Sordaria macrospora k-hell
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.