STRINGSTRING
SMAC_00124 SMAC_00124 SMAC_00083 SMAC_00083 CHO2 CHO2 SMAC_09261 SMAC_09261 SMAC_08815 SMAC_08815 SMAC_08035 SMAC_08035 SMAC_07090 SMAC_07090 TRM8 TRM8 SMAC_06142 SMAC_06142 EFM6 EFM6 SMAC_05510 SMAC_05510 SMAC_02243 SMAC_02243 SMAC_03850 SMAC_03850 SMAC_04457 SMAC_04457 SMAC_06719 SMAC_06719 SMAC_06682 SMAC_06682 TRM5 TRM5 SPB1 SPB1 EFM7 EFM7 SMAC_03688 SMAC_03688 SMAC_03559 SMAC_03559 EFM5 EFM5 SMAC_05186 SMAC_05186 SMAC_08355 SMAC_08355 SMAC_06009 SMAC_06009 SMAC_05962 SMAC_05962 SMAC_05795 SMAC_05795 SMAC_05478 SMAC_05478 SMAC_01830 SMAC_01830 SMAC_01697 SMAC_01697 SMAC_01688 SMAC_01688 SMAC_01479 SMAC_01479 SMAC_01214 SMAC_01214 SMAC_06771 SMAC_06771 SMAC_02391 SMAC_02391 SMAC_02353 SMAC_02353 SMAC_01012 SMAC_01012 COQ5 COQ5 SMAC_01188 SMAC_01188
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAC_00124Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (312 aa)
SMAC_00083Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (533 aa)
CHO2Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. (963 aa)
SMAC_09261Putative polyketide synthase protein. (2571 aa)
SMAC_08815WGS project CABT00000000 data, contig 2.66. (796 aa)
SMAC_08035Arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. (434 aa)
SMAC_0709025S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (305 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (293 aa)
SMAC_06142mRNA cap guanine-N7 methyltransferase. (577 aa)
EFM6Protein-lysine N-methyltransferase EFM6; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily. (234 aa)
SMAC_05510rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (401 aa)
SMAC_02243Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (571 aa)
SMAC_03850Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). (214 aa)
SMAC_04457WGS project CABT00000000 data, contig 2.14; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (336 aa)
SMAC_06719WGS project CABT00000000 data, contig 2.13; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (729 aa)
SMAC_06682WGS project CABT00000000 data, contig 2.13; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (907 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (423 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
EFM7Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono-and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (284 aa)
SMAC_03688WGS project CABT00000000 data, contig 2.9; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1536 aa)
SMAC_03559rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (791 aa)
EFM5Protein-lysine N-methyltransferase EFM5; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates elongation factor 1-alpha at 'Lys- 79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family. (282 aa)
SMAC_05186WGS project CABT00000000 data, contig 2.8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (335 aa)
SMAC_08355Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (380 aa)
SMAC_06009Putative polyketide synthase. (1973 aa)
SMAC_05962WGS project CABT00000000 data, contig 2.6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (744 aa)
SMAC_05795Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (508 aa)
SMAC_05478WGS project CABT00000000 data, contig 2.6; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (872 aa)
SMAC_01830Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (430 aa)
SMAC_01697Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family. (520 aa)
SMAC_01688WGS project CABT00000000 data, contig 2.5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (862 aa)
SMAC_01479WGS project CABT00000000 data, contig 2.4. (357 aa)
SMAC_01214Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (382 aa)
SMAC_06771WGS project CABT00000000 data, contig 2.3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (666 aa)
SMAC_02391WGS project CABT00000000 data, contig 2.3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (589 aa)
SMAC_02353Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. (792 aa)
SMAC_01012WGS project CABT00000000 data, contig 2.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (713 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (346 aa)
SMAC_01188Putative polyketide synthase. (2636 aa)
Your Current Organism:
Sordaria macrospora
NCBI taxonomy Id: 771870
Other names: S. macrospora k-hell, Sordaria macrospora k-hell
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.