STRINGSTRING
SMAC_01872 SMAC_01872 SMAC_05349 SMAC_05349 SMAC_09496 SMAC_09496 ATG7 ATG7 ATG12 ATG12 SMAC_03977 SMAC_03977 SMAC_03887 SMAC_03887 SMAC_03824 SMAC_03824 SMAC_07844 SMAC_07844 SMAC_07824 SMAC_07824 SMAC_12724 SMAC_12724 MDM34 MDM34 SMAC_06685 SMAC_06685 SMAC_02854 SMAC_02854 SMAC_02852 SMAC_02852 SMAC_02759 SMAC_02759 SMAC_02677 SMAC_02677 SMAC_03355 SMAC_03355 SMAC_03256 SMAC_03256 SMAC_03472 SMAC_03472 SMAC_03681 SMAC_03681 SMAC_03610 SMAC_03610 SMAC_03525 SMAC_03525 SMAC_08312 SMAC_08312 SMAC_08321 SMAC_08321 SMAC_05013 SMAC_05013 SMAC_03011 SMAC_03011 SMAC_03134 SMAC_03134 SMAC_07561 SMAC_07561 SMAC_08343 SMAC_08343 SMAC_08340 SMAC_08340 SMAC_06004 SMAC_06004 SMAC_06001 SMAC_06001 ATG3 ATG3 SMAC_01920 SMAC_01920 SMAC_07161 SMAC_07161 SMAC_07033 SMAC_07033 SMAC_06292 SMAC_06292 SMAC_06073 SMAC_06073 SMAC_06048 SMAC_06048 SMAC_07925 SMAC_07925 SMAC_00084 SMAC_00084 SMAC_00182 SMAC_00182 SMAC_00490 SMAC_00490 SMAC_00601 SMAC_00601 SMAC_04841 SMAC_04841 SMAC_00641 SMAC_00641 SMAC_00692 SMAC_00692 SMAC_00700 SMAC_00700 SMAC_00892 SMAC_00892 SMAC_06209 SMAC_06209 SMAC_02305 SMAC_02305 SMAC_02473 SMAC_02473 SMAC_06724 SMAC_06724 SMAC_01337 SMAC_01337 SMAC_01870 SMAC_01870 SMAC_02237 SMAC_02237 SMAC_04758 SMAC_04758 SMAC_04753 SMAC_04753 SMAC_04262 SMAC_04262 SMAC_04225 SMAC_04225 SMAC_01873 SMAC_01873
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAC_01872WGS project CABT00000000 data, contig 2.5. (227 aa)
SMAC_05349WGS project CABT00000000 data, contig 2.25. (274 aa)
SMAC_09496WGS project CABT00000000 data, contig 2.51. (475 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine (By similarity). Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleoph [...] (699 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy (By similarity). Conjugation with ATG5 through a ubiquitin- like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity). The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes. ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E [...] (159 aa)
SMAC_03977WGS project CABT00000000 data, contig 2.17. (226 aa)
SMAC_03887WGS project CABT00000000 data, contig 2.16. (175 aa)
SMAC_03824Non-specific serine/threonine protein kinase. (856 aa)
SMAC_07844WGS project CABT00000000 data, contig 2.14. (863 aa)
SMAC_07824WGS project CABT00000000 data, contig 2.14. (624 aa)
SMAC_12724WGS project CABT00000000 data, contig 2.14. (102 aa)
MDM34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (583 aa)
SMAC_06685Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. (2835 aa)
SMAC_02854WGS project CABT00000000 data, contig 2.12. (327 aa)
SMAC_02852WGS project CABT00000000 data, contig 2.12. (514 aa)
SMAC_02759WGS project CABT00000000 data, contig 2.11. (228 aa)
SMAC_02677WGS project CABT00000000 data, contig 2.11. (456 aa)
SMAC_03355WGS project CABT00000000 data, contig 2.10. (156 aa)
SMAC_03256Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (1021 aa)
SMAC_03472Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (1006 aa)
SMAC_03681WGS project CABT00000000 data, contig 2.9. (975 aa)
SMAC_03610WGS project CABT00000000 data, contig 2.9. (129 aa)
SMAC_03525WGS project CABT00000000 data, contig 2.9; Involved in DNA replication and cell separation. Belongs to the SDS23 family. (544 aa)
SMAC_08312Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (911 aa)
SMAC_08321Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (515 aa)
SMAC_05013WGS project CABT00000000 data, contig 2.8; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
SMAC_03011WGS project CABT00000000 data, contig 2.7. (263 aa)
SMAC_03134Non-specific serine/threonine protein kinase. (706 aa)
SMAC_07561WGS project CABT00000000 data, contig 2.7. (349 aa)
SMAC_08343Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (366 aa)
SMAC_08340WGS project CABT00000000 data, contig 2.7. (386 aa)
SMAC_06004WGS project CABT00000000 data, contig 2.6. (550 aa)
SMAC_06001WGS project CABT00000000 data, contig 2.6. (379 aa)
ATG3Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8 (By similarity). The ATG12-ATG5 conjugate pla [...] (346 aa)
SMAC_01920Putative myotubularin-like protein. (824 aa)
SMAC_07161WGS project CABT00000000 data, contig 2.40. (487 aa)
SMAC_07033WGS project CABT00000000 data, contig 2.36; Belongs to the peptidase C19 family. (759 aa)
SMAC_06292WGS project CABT00000000 data, contig 2.34. (807 aa)
SMAC_06073WGS project CABT00000000 data, contig 2.32. (154 aa)
SMAC_06048WGS project CABT00000000 data, contig 2.32. (291 aa)
SMAC_07925WGS project CABT00000000 data, contig 2.29. (229 aa)
SMAC_00084WGS project CABT00000000 data, contig 2.1. (233 aa)
SMAC_00182WGS project CABT00000000 data, contig 2.1. (720 aa)
SMAC_00490WGS project CABT00000000 data, contig 2.1. (732 aa)
SMAC_00601WGS project CABT00000000 data, contig 2.1. (1101 aa)
SMAC_04841WGS project CABT00000000 data, contig 2.1. (259 aa)
SMAC_00641WGS project CABT00000000 data, contig 2.2. (302 aa)
SMAC_00692WGS project CABT00000000 data, contig 2.2. (178 aa)
SMAC_00700Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (333 aa)
SMAC_00892WGS project CABT00000000 data, contig 2.2. (290 aa)
SMAC_06209WGS project CABT00000000 data, contig 2.3. (323 aa)
SMAC_02305Autophagy-related protein. (121 aa)
SMAC_02473WGS project CABT00000000 data, contig 2.3. (235 aa)
SMAC_06724WGS project CABT00000000 data, contig 2.3. (217 aa)
SMAC_01337Phosphatidylinositol 3-kinase VPS34. (914 aa)
SMAC_01870WGS project CABT00000000 data, contig 2.5. (155 aa)
SMAC_02237WGS project CABT00000000 data, contig 2.23. (972 aa)
SMAC_04758WGS project CABT00000000 data, contig 2.21. (233 aa)
SMAC_04753WGS project CABT00000000 data, contig 2.21. (1551 aa)
SMAC_04262Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (287 aa)
SMAC_04225WGS project CABT00000000 data, contig 2.19. (1330 aa)
SMAC_01873Putative mitochondrial fission protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (919 aa)
Your Current Organism:
Sordaria macrospora
NCBI taxonomy Id: 771870
Other names: S. macrospora k-hell, Sordaria macrospora k-hell
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