STRINGSTRING
AFG36091.1 AFG36091.1 AFG34191.1 AFG34191.1 fliW fliW csrA csrA AFG34242.1 AFG34242.1 AFG34260.1 AFG34260.1 AFG34280.1 AFG34280.1 AFG34290.1 AFG34290.1 AFG34181.1 AFG34181.1 AFG34306.1 AFG34306.1 AFG34333.1 AFG34333.1 pnp pnp infC infC AFG34427.1 AFG34427.1 AFG34436.1 AFG34436.1 efp efp nusB nusB hfq hfq AFG34512.1 AFG34512.1 AFG34523.1 AFG34523.1 AFG34531.1 AFG34531.1 AFG34553.1 AFG34553.1 AFG34555.1 AFG34555.1 AFG34577.1 AFG34577.1 AFG34656.1 AFG34656.1 AFG34673.1 AFG34673.1 AFG34706.1 AFG34706.1 tsf tsf AFG34764.1 AFG34764.1 AFG34773.1 AFG34773.1 AFG34796.1 AFG34796.1 AFG34807.1 AFG34807.1 AFG34816.1 AFG34816.1 prfA prfA rsfS rsfS prfA-2 prfA-2 AFG34898.1 AFG34898.1 AFG34934.1 AFG34934.1 AFG34942.1 AFG34942.1 AFG34952.1 AFG34952.1 AFG34963.1 AFG34963.1 rex rex rex-2 rex-2 AFG35025.1 AFG35025.1 nusA nusA AFG35048.1 AFG35048.1 AFG35062.1 AFG35062.1 AFG35098.1 AFG35098.1 AFG35104.1 AFG35104.1 AFG35105.1 AFG35105.1 lexA lexA AFG35115.1 AFG35115.1 AFG35131.1 AFG35131.1 AFG35184.1 AFG35184.1 AFG35248.1 AFG35248.1 AFG35249.1 AFG35249.1 rplA rplA nusG nusG AFG35284.1 AFG35284.1 AFG35316.1 AFG35316.1 AFG35381.1 AFG35381.1 AFG35409.1 AFG35409.1 AFG35410.1 AFG35410.1 AFG35458.1 AFG35458.1 AFG35460.1 AFG35460.1 infA infA tuf tuf fusA fusA AFG35539.1 AFG35539.1 nrdR nrdR greA greA AFG35583.1 AFG35583.1 lepA lepA AFG35628.1 AFG35628.1 AFG35630.1 AFG35630.1 infB infB AFG35661.1 AFG35661.1 AFG35676.1 AFG35676.1 AFG35687.1 AFG35687.1 AFG35696.1 AFG35696.1 AFG35699.1 AFG35699.1 AFG35703.1 AFG35703.1 rny rny AFG35748.1 AFG35748.1 AFG35775.1 AFG35775.1 AFG35792.1 AFG35792.1 AFG35812.1 AFG35812.1 AFG35832.1 AFG35832.1 AFG35845.1 AFG35845.1 AFG35852.1 AFG35852.1 infB-2 infB-2 AFG35856.1 AFG35856.1 AFG35864.1 AFG35864.1 AFG35893.1 AFG35893.1 AFG35920.1 AFG35920.1 hrcA hrcA AFG35936.1 AFG35936.1 AFG35948.1 AFG35948.1 AFG36004.1 AFG36004.1 AFG36031.1 AFG36031.1 mfd mfd prfB prfB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFG36091.1Rrf2 family protein, putative transcriptional regulator; PFAM: Transcriptional regulator. (137 aa)
AFG34191.1PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV. (685 aa)
fliWHypothetical protein; Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum. (158 aa)
csrACarbon storage regulator CsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (93 aa)
AFG34242.1PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (240 aa)
AFG34260.1RNA polymerase sigma factor, sigma-70 family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (371 aa)
AFG34280.1Looped-hinge helix DNA binding domain, AbrB family; PFAM: SpoVT / AbrB like domain. (93 aa)
AFG34290.1PFAM: Bacterial regulatory proteins, gntR family; FCD domain. (251 aa)
AFG34181.1PAS domain S-box; PFAM: Bacterial regulatory protein, Fis family; Sigma-54 interaction domain; PAS fold. (567 aa)
AFG34306.1PFAM: Bacterial regulatory proteins, lacI family; family. (332 aa)
AFG34333.1RNA polymerase, sigma 28 subunit, SigD/FliA/WhiG; PFAM: Sigma-70, region 4; Sigma-70 region 3; Sigma-70 region 2; Belongs to the sigma-70 factor family. (251 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (694 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (153 aa)
AFG34427.1Hypothetical protein. (89 aa)
AFG34436.1RNA polymerase, sigma 30 subunit, SigH; PFAM: Sigma-70, region 4; Sigma-70 region 2; Belongs to the sigma-70 factor family. (207 aa)
efpTranslation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa)
nusBTranscription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (141 aa)
hfqRNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (97 aa)
AFG34512.1Mn-dependent transcriptional regulator; PFAM: Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain. (172 aa)
AFG34523.1Mn-dependent transcriptional regulator; PFAM: Iron dependent repressor, N-terminal DNA binding domain. (177 aa)
AFG34531.1Transcriptional regulator; PFAM: MarR family. (154 aa)
AFG34553.1Prevent-host-death family protein; Antitoxin component of a type II toxin-antitoxin (TA) system. (97 aa)
AFG34555.1PFAM: Bacterial regulatory proteins, tetR family. (188 aa)
AFG34577.1PFAM: Bacterial regulatory proteins, lacI family; family. (335 aa)
AFG34656.1Fe2+/Zn2+ uptake regulation protein; PFAM: Ferric uptake regulator family; Belongs to the Fur family. (144 aa)
AFG34673.1Uncharacterized protein, YfiH family; PFAM: Multi-copper polyphenol oxidoreductase laccase; Belongs to the multicopper oxidase YfiH/RL5 family. (269 aa)
AFG34706.1Putative transcriptional regulator; PFAM: Bacterial regulatory protein, arsR family. (99 aa)
tsfTranslation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (197 aa)
AFG34764.1PFAM: Bacterial regulatory proteins, tetR family. (413 aa)
AFG34773.1Ribosome-associated protein Y (PSrp-1); PFAM: Sigma 54 modulation protein / S30EA ribosomal protein. (184 aa)
AFG34796.1Putative transcriptional regulator; PFAM: Bacterial regulatory protein, arsR family. (124 aa)
AFG34807.1PFAM: Bacterial regulatory proteins, lacI family; family. (337 aa)
AFG34816.1Hypothetical protein. (66 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (349 aa)
rsfSIojap-like ribosome-associated protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (118 aa)
prfA-2Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (349 aa)
AFG34898.1Transcriptional regulator; PFAM: MarR family. (154 aa)
AFG34934.1PFAM: Bacterial regulatory proteins, lacI family; family. (338 aa)
AFG34942.1Putative redox protein, regulator of disulfide bond formation; PFAM: Bacterial regulatory protein, arsR family; SirA-like protein; Belongs to the sulfur carrier protein TusA family. (201 aa)
AFG34952.1Putative transcriptional regulator; PFAM: Bacterial regulatory proteins, gntR family. (138 aa)
AFG34963.1PFAM: Bacterial regulatory proteins, lacI family; family. (332 aa)
rexAT-rich DNA-binding protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (214 aa)
rex-2AT-rich DNA-binding protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (231 aa)
AFG35025.1Putative small molecule binding protein (contains 3H domain); PFAM: HTH domain; 3H domain. (177 aa)
nusATranscription termination factor NusA; Participates in both transcription termination and antitermination. (344 aa)
AFG35048.1Fe2+/Zn2+ uptake regulation protein; PFAM: Ferric uptake regulator family; Belongs to the Fur family. (146 aa)
AFG35062.1RNA polymerase, sigma-24 subunit, RpoE; PFAM: Sigma-70, region 4; Sigma-70 region 2; Belongs to the sigma-70 factor family. ECF subfamily. (221 aa)
AFG35098.1PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (229 aa)
AFG35104.1Anti-anti-sigma factor; PFAM: STAS domain; Belongs to the anti-sigma-factor antagonist family. (111 aa)
AFG35105.1Anti-anti-sigma factor; PFAM: STAS domain; Belongs to the anti-sigma-factor antagonist family. (111 aa)
lexASOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (198 aa)
AFG35115.1DRTGG domain-containing protein; PFAM: DRTGG domain. (109 aa)
AFG35131.1Transcriptional regulator; PFAM: Helix-turn-helix domain, rpiR family; SIS domain. (278 aa)
AFG35184.1Putative transcriptional regulator containing CBS domains; PFAM: CBS domain. (155 aa)
AFG35248.1PFAM: 'Cold-shock' DNA-binding domain. (66 aa)
AFG35249.1PFAM: 'Cold-shock' DNA-binding domain. (66 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (235 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (355 aa)
AFG35284.1Fe2+/Zn2+ uptake regulation protein; PFAM: Ferric uptake regulator family; Belongs to the Fur family. (122 aa)
AFG35316.1PFAM: Bacterial regulatory proteins, lacI family; family. (347 aa)
AFG35381.1Hypothetical protein; PFAM: Activator of Hsp90 ATPase homolog 1-like protein. (147 aa)
AFG35409.1Putative nucleoside-diphosphate sugar epimerase; PFAM: Bacterial regulatory protein, arsR family. (213 aa)
AFG35410.1Hypothetical protein. (443 aa)
AFG35458.1DNA-binding regulatory protein, YebC/PmpR family; PFAM: Domain of unknown function DUF28. (252 aa)
AFG35460.1FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); PFAM: Bacterial trigger factor protein (TF); Bacterial trigger factor protein (TF) C-terminus. (443 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (90 aa)
tufTranslation elongation factor TU; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa)
fusATranslation elongation factor EF-G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (692 aa)
AFG35539.1Putative P-loop-containing kinase; Displays ATPase and GTPase activities. (282 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (156 aa)
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (156 aa)
AFG35583.1PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold. (909 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (604 aa)
AFG35628.1PFAM: Uncharacterized protein family UPF0029. (200 aa)
AFG35630.1DNA-directed RNA polymerase specialized sigma subunit, sigma24; PFAM: Sigma-54, DNA binding domain. (304 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (690 aa)
AFG35661.1PFAM: Bacterial regulatory proteins, lacI family; family. (329 aa)
AFG35676.1Hypothetical protein; Manually curated. (257 aa)
AFG35687.1PFAM: Cyclic nucleotide-binding domain. (107 aa)
AFG35696.1PFAM: Cyclic nucleotide-binding domain. (231 aa)
AFG35699.1Putative transcriptional regulator; PFAM: HTH domain. (60 aa)
AFG35703.1birA, biotin-(acetyl-CoA-carboxylase) ligase; PFAM: Biotin/lipoate A/B protein ligase family. (237 aa)
rnyHypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (517 aa)
AFG35748.1Hypothetical protein. (371 aa)
AFG35775.1PFAM: Bacterial regulatory proteins, lacI family. (322 aa)
AFG35792.1PP-loop superfamily ATP-utilizing enzyme; PFAM: ATP-binding region. (216 aa)
AFG35812.1DRTGG domain-containing protein; PFAM: DRTGG domain. (118 aa)
AFG35832.1PFAM: Bacterial regulatory proteins, lacI family; family. (324 aa)
AFG35845.1Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; PFAM: Response regulator receiver domain. (119 aa)
AFG35852.1PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (231 aa)
infB-2Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (684 aa)
AFG35856.1Transcriptional regulator. (164 aa)
AFG35864.1PFAM: Bacterial regulatory proteins, lacI family; family. (333 aa)
AFG35893.1PFAM: Bacterial regulatory proteins, lacI family; family. (338 aa)
AFG35920.1PFAM: Transcriptional regulator PadR-like family. (126 aa)
hrcAHeat shock gene repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (349 aa)
AFG35936.1Anti-anti-sigma factor; PFAM: STAS domain; Belongs to the anti-sigma-factor antagonist family. (109 aa)
AFG35948.1PAS domain S-box; PFAM: PAS fold. (408 aa)
AFG36004.1Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains; PFAM: Response regulator receiver domain. (210 aa)
AFG36031.1PFAM: Anti-sigma-28 factor, FlgM. (95 aa)
mfdTranscription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (929 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (369 aa)
Your Current Organism:
Fervidobacterium pennivorans
NCBI taxonomy Id: 771875
Other names: F. pennivorans DSM 9078, Fervidobacterium pennivorans DSM 9078, Fervidobacterium pennivorans str. DSM 9078, Fervidobacterium pennivorans strain DSM 9078
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.