STRINGSTRING
AFG34627.1 AFG34627.1 ackA ackA AFG35442.1 AFG35442.1 adk adk ldh ldh pfp pfp coaX coaX AFG35556.1 AFG35556.1 pgi pgi coaE coaE AFG35583.1 AFG35583.1 AFG35717.1 AFG35717.1 AFG35758.1 AFG35758.1 AFG35818.1 AFG35818.1 AFG35827.1 AFG35827.1 AFG35853.1 AFG35853.1 AFG35922.1 AFG35922.1 cmk cmk eno eno AFG35981.1 AFG35981.1 AFG35989.1 AFG35989.1 AFG36006.1 AFG36006.1 gmk gmk ispE ispE pfkA pfkA AFG36074.1 AFG36074.1 AFG36108.1 AFG36108.1 rbsK rbsK AFG34348.1 AFG34348.1 AFG34354.1 AFG34354.1 AFG34638.1 AFG34638.1 AFG34639.1 AFG34639.1 AFG34645.1 AFG34645.1 AFG34772.1 AFG34772.1 AFG34359.1 AFG34359.1 AFG34818.1 AFG34818.1 AFG34960.1 AFG34960.1 prs prs AFG34997.1 AFG34997.1 AFG35043.1 AFG35043.1 apgM apgM tmk tmk AFG35097.1 AFG35097.1 tdk tdk AFG35117.1 AFG35117.1 AFG35130.1 AFG35130.1 pyrH pyrH AFG35185.1 AFG35185.1 AFG35236.1 AFG35236.1 ndk ndk AFG35262.1 AFG35262.1 AFG35353.1 AFG35353.1 AFG35380.1 AFG35380.1 AFG35418.1 AFG35418.1 AFG34243.1 AFG34243.1 AFG34289.1 AFG34289.1 AFG34292.1 AFG34292.1 pgk pgk tpiA tpiA AFG34455.1 AFG34455.1 AFG34467.1 AFG34467.1 buk buk buk-2 buk-2 AFG34513.1 AFG34513.1 nadK nadK AFG34550.1 AFG34550.1 AFG34616.1 AFG34616.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFG34627.1PFAM: Fructose-bisphosphate aldolase class-II. (311 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa)
AFG35442.1Anti-sigma regulatory factor (Ser/Thr protein kinase). (153 aa)
adkAdenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (312 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (392 aa)
coaXPantothenate kinase, type III; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa)
AFG35556.1Putative glycerate kinase; PFAM: MOFRL family. (426 aa)
pgiPFAM: Phosphoglucose isomerase; Belongs to the GPI family. (453 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (179 aa)
AFG35583.1PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold. (909 aa)
AFG35717.1Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; Belongs to the aspartokinase family. (466 aa)
AFG35758.1PFAM: Cobinamide kinase / cobinamide phosphate guanyltransferase. (165 aa)
AFG35818.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (333 aa)
AFG35827.11-phosphofructokinase; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family. (309 aa)
AFG35853.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (337 aa)
AFG35922.1Putative regulator of cell autolysis; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (329 aa)
cmkPFAM: Cytidylate kinase. (226 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
AFG35981.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (451 aa)
AFG35989.1Hypothetical protein; PFAM: PASTA domain. (262 aa)
AFG36006.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (614 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (217 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (269 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
AFG36074.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 4'-phosphopantetheinyl transferase superfamily; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); Belongs to the P-Pant transferase superfamily. (278 aa)
AFG36108.1PFAM: Amino acid kinase family; Belongs to the carbamate kinase family. (311 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (305 aa)
AFG34348.1Riboflavin kinase/FMN adenylyltransferase; PFAM: Riboflavin kinase; FAD synthetase; Belongs to the ribF family. (312 aa)
AFG34354.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (470 aa)
AFG34638.1PFAM: Phosphoribulokinase / Uridine kinase family. (201 aa)
AFG34639.1Transcriptional regulator/sugar kinase; PFAM: ROK family. (373 aa)
AFG34645.1Sugar kinase, ribokinase; PFAM: pfkB family carbohydrate kinase. (335 aa)
AFG34772.1Hypothetical protein; PFAM: Phosphomethylpyrimidine kinase; Archaeal phosphomethylpyrimidine kinase. (409 aa)
AFG34359.1Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (481 aa)
AFG34818.1Thiamine diphosphokinase; PFAM: Thiamin pyrophosphokinase, vitamin B1 binding domain; Thiamin pyrophosphokinase, catalytic domain. (206 aa)
AFG34960.1PFAM: Galactokinase galactose-binding signature; GHMP kinases C terminal; GHMP kinases N terminal domain; Belongs to the GHMP kinase family. GalK subfamily. (356 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
AFG34997.1Pyruvate phosphate dikinase; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Belongs to the PEP-utilizing enzyme family. (881 aa)
AFG35043.1Putative transcriptional regulator, contains C-terminal CBS domains; PFAM: CBS domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (313 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (403 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (199 aa)
AFG35097.1PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (409 aa)
tdkPFAM: Thymidine kinase. (200 aa)
AFG35117.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (179 aa)
AFG35130.1Transcriptional regulator/sugar kinase; PFAM: ROK family. (295 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (234 aa)
AFG35185.1Fructose-1-phosphate kinase/fructose-6-phosphate kinase; PFAM: pfkB family carbohydrate kinase; Belongs to the carbohydrate kinase PfkB family. (317 aa)
AFG35236.1PFAM: Prokaryotic diacylglycerol kinase. (158 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa)
AFG35262.1PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. (520 aa)
AFG35353.1PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; Belongs to the pyruvate kinase family. (471 aa)
AFG35380.1Thiamine diphosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic domain. (206 aa)
AFG35418.1Sugar kinase, ribokinase; PFAM: pfkB family carbohydrate kinase. (291 aa)
AFG34243.1PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (429 aa)
AFG34289.1PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. (486 aa)
AFG34292.1PFAM: FGGY family of carbohydrate kinases, N-terminal domain; FGGY family of carbohydrate kinases, C-terminal domain. (516 aa)
pgkPFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa)
AFG34455.1PFAM: Amino acid kinase family; manually curated; Belongs to the aspartokinase family. (407 aa)
AFG34467.1Transcriptional regulator/sugar kinase; PFAM: ROK family. (313 aa)
bukPFAM: Acetokinase family; Belongs to the acetokinase family. (358 aa)
buk-2PFAM: Acetokinase family; Belongs to the acetokinase family. (361 aa)
AFG34513.1PFAM: Phosphoribulokinase / Uridine kinase family. (557 aa)
nadKPutative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (267 aa)
AFG34550.1Transcriptional regulator/sugar kinase; PFAM: ROK family; IclR helix-turn-helix domain. (380 aa)
AFG34616.1Chemotaxis protein histidine kinase-like protein; PFAM: CheW-like domain; P2 response regulator binding domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (681 aa)
Your Current Organism:
Fervidobacterium pennivorans
NCBI taxonomy Id: 771875
Other names: F. pennivorans DSM 9078, Fervidobacterium pennivorans DSM 9078, Fervidobacterium pennivorans str. DSM 9078, Fervidobacterium pennivorans strain DSM 9078
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