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| | smpB | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (147 aa) |
| | AFG36110.1 | PFAM: D-aminopeptidase; IMG reference gene:2507208173_SP. (279 aa) |
| | rplJ | Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (182 aa) |
| | rplL | LSU ribosomal protein L12P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (129 aa) |
| | prfB | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (369 aa) |
| | AFG36052.1 | Transglutaminase-like enzyme, predicted cysteine protease; PFAM: Transglutaminase-like superfamily. (449 aa) |
| | AFG36027.1 | PFAM: Ribosomal protein L11 methyltransferase (PrmA). (268 aa) |
| | AFG36022.1 | Putative ATP-dependent protease; PFAM: Lon protease (S16) C-terminal proteolytic domain. (793 aa) |
| | AFG36018.1 | Hypothetical protein; PFAM: LemA family. (189 aa) |
| | AFG36006.1 | PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (614 aa) |
| | AFG35995.1 | C-terminal processing peptidase; PFAM: Peptidase family S41; PDZ domain (Also known as DHR or GLGF); Belongs to the peptidase S41A family. (407 aa) |
| | AFG35989.1 | Hypothetical protein; PFAM: PASTA domain. (262 aa) |
| | AFG35985.1 | Peptidase family protein; PFAM: M42 glutamyl aminopeptidase. (335 aa) |
| | AFG35981.1 | PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (451 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (404 aa) |
| | rpsO | Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (84 aa) |
| | AFG35958.1 | Putative Zn-dependent protease-like protein; PFAM: Putative modulator of DNA gyrase. (465 aa) |
| | AFG35957.1 | Putative Zn-dependent protease-like protein; PFAM: Putative modulator of DNA gyrase. (435 aa) |
| | AFG35955.1 | Oligoendopeptidase, pepF/M3 family; PFAM: Oligopeptidase F; Peptidase family M3. (585 aa) |
| | AFG35951.1 | Putative membrane protein; PFAM: Rhomboid family. (216 aa) |
| | gatB | glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (479 aa) |
| | gatA | glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (464 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (573 aa) |
| | rpsB | PFAM: Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (258 aa) |
| | AFG35922.1 | Putative regulator of cell autolysis; PFAM: Histidine kinase; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. (329 aa) |
| | hisS | PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T). (421 aa) |
| | AFG35907.1 | Beta-propeller domain-containing protein, methanol dehydrogenase; PFAM: Domain of unknown function (DUF477). (247 aa) |
| | AFG35862.1 | Zn-dependent protease with chaperone function; PFAM: Peptidase family M48. (315 aa) |
| | infB-2 | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (684 aa) |
| | AFG35853.1 | PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (337 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (912 aa) |
| | AFG35804.1 | PFAM: Biotin/lipoate A/B protein ligase family. (253 aa) |
| | AFG35792.1 | PP-loop superfamily ATP-utilizing enzyme; PFAM: ATP-binding region. (216 aa) |
| | AFG35783.1 | PFAM: CAAX amino terminal protease family. (414 aa) |
| | AFG35746.1 | Zn-dependent protease with chaperone function; PFAM: Peptidase family M48. (415 aa) |
| | rimO | SSU ribosomal protein S12P methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (431 aa) |
| | AFG35702.1 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4); PFAM: D-Ala-D-Ala carboxypeptidase 3 (S13) family. (408 aa) |
| | AFG35671.1 | Putative Zn-dependent protease; PFAM: Putative neutral zinc metallopeptidase. (225 aa) |
| | asnS | PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain. (433 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (690 aa) |
| | AFG35624.1 | Hypothetical protein. (498 aa) |
| | AFG35595.1 | Dipeptidyl aminopeptidase/acylaminoacyl peptidase; PFAM: Prolyl oligopeptidase family. (668 aa) |
| | AFG35591.1 | PFAM: tRNA synthetases class I (W and Y); Belongs to the class-I aminoacyl-tRNA synthetase family. (327 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (604 aa) |
| | AFG35588.1 | PFAM: Oligopeptidase F; Peptidase family M3. (578 aa) |
| | AFG35583.1 | PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold. (909 aa) |
| | lysS | lysyl-tRNA synthetase (class II); PFAM: tRNA synthetases class II (D, K and N); OB-fold nucleic acid binding domain; Belongs to the class-II aminoacyl-tRNA synthetase family. (505 aa) |
| | AFG35535.1 | PFAM: Peptidase family M50. (206 aa) |
| | AFG35525.1 | Hypothetical protein. (235 aa) |
| | AFG35506.1 | protein-(glutamine-N5) methyltransferase, release factor-specific; PFAM: Methyltransferase small domain. (272 aa) |
| | rplI | LSU ribosomal protein L9P; Binds to the 23S rRNA. (150 aa) |
| | rpsL | Ribosomal protein S12, bacterial/organelle; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. (134 aa) |
| | rpsG | SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (155 aa) |
| | fusA | Translation elongation factor EF-G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...] (692 aa) |
| | tuf | Translation elongation factor TU; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (399 aa) |
| | rpsJ | SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | rplC | 50S ribosomal protein L3, bacterial; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (210 aa) |
| | rplD | 50S ribosomal protein L4, bacterial/organelle; Forms part of the polypeptide exit tunnel. (223 aa) |
| | rplW | Ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (100 aa) |
| | rplB | Ribosomal protein L2, bacterial/organellar; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (275 aa) |
| | rpsS | Ribosomal protein S19, bacterial/organelle; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (95 aa) |
| | rplV | LSU ribosomal protein L22P; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (149 aa) |
| | rpsC | Ribosomal protein S3, bacterial type; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rplP | LSU ribosomal protein L16P; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (142 aa) |
| | rpmC | PFAM: Ribosomal L29 protein; Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | rpsQ | SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (102 aa) |
| | rplN | LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rplX | LSU ribosomal protein L24P; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (107 aa) |
| | rplE | Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (184 aa) |
| | rpsZ | Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rpsH | Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (134 aa) |
| | rplF | LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rplR | LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (122 aa) |
| | rpsE | Ribosomal protein S5, bacterial/organelle type; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (176 aa) |
| | rpmD | PFAM: Ribosomal protein L30p/L7e. (61 aa) |
| | rplO | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (151 aa) |
| | map | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (249 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (90 aa) |
| | rpmJ | Ribosomal protein L36, bacterial type; PFAM: Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa) |
| | rpsM | SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (123 aa) |
| | rpsK | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpsD | SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (209 aa) |
| | rplQ | PFAM: Ribosomal protein L17. (128 aa) |
| | clpP | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (206 aa) |
| | AFG35456.1 | Methylase of chemotaxis methyl-accepting protein; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain. (284 aa) |
| | AFG35431.1 | Subtilisin-like serine protease; PFAM: Subtilase family; Belongs to the peptidase S8 family. (697 aa) |
| | AFG35422.1 | Peptidase family protein; PFAM: M42 glutamyl aminopeptidase. (358 aa) |
| | AFG35421.1 | Peptidase family protein; PFAM: M42 glutamyl aminopeptidase. (335 aa) |
| | AFG35419.1 | Subtilisin-like serine protease; PFAM: Subtilase family; Belongs to the peptidase S8 family. (699 aa) |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (319 aa) |
| | lgt | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (295 aa) |
| | AFG35406.1 | Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; PFAM: CheB methylesterase. (197 aa) |
| | AFG35403.1 | Methylase of chemotaxis methyl-accepting protein; PFAM: CheR methyltransferase, SAM binding domain. (390 aa) |
| | AFG35397.1 | Hypothetical protein. (233 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetase B5 domain; B3/4 domain; Ferredoxin-fold anticodon binding domain; Putative tRNA binding domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (780 aa) |
| | AFG35378.1 | Putative membrane-associated Zn-dependent protease; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF). (496 aa) |
| | def-2 | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (166 aa) |
| | AFG35369.1 | Periplasmic serine protease, Do/DeqQ family; PFAM: Trypsin; PDZ domain (Also known as DHR or GLGF). (458 aa) |
| | AFG35367.1 | Prepilin signal peptidase PulO-like peptidase; PFAM: Bacterial Peptidase A24 N-terminal domain; Type IV leader peptidase family. (238 aa) |
| | rpmB | LSU ribosomal protein L28P; PFAM: Ribosomal L28 family; Belongs to the bacterial ribosomal protein bL28 family. (73 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); Aminoacyl tRNA synthetase class II, N-terminal domain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (333 aa) |
| | rpmH | PFAM: Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | AFG35308.1 | Esterase/lipase; PFAM: Prolyl oligopeptidase family. (331 aa) |
| | glyQ | PFAM: Glycyl-tRNA synthetase alpha subunit. (284 aa) |
| | glyS | PFAM: Glycyl-tRNA synthetase beta subunit; DALR anticodon binding domain. (670 aa) |
| | rpmG | PFAM: Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | rplK | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (235 aa) |
| | AFG35265.1 | ClpP class periplasmic serine protease; PFAM: Serine dehydrogenase proteinase; manually curated. (275 aa) |
| | AFG35263.1 | Subtilisin-like serine protease; PFAM: Subtilase family; Belongs to the peptidase S8 family. (439 aa) |
| | AFG35258.1 | Hypothetical protein. (472 aa) |
| | AFG35241.1 | Membrane carboxypeptidase (penicillin-binding protein); PFAM: Penicillin binding protein transpeptidase domain; Transglycosylase. (684 aa) |
| | cheB | Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (345 aa) |
| | AFG35225.1 | Pyroglutamyl-peptidase I; Removes 5-oxoproline from various penultimate amino acid residues except L-proline. (214 aa) |
| | AFG35197.1 | Membrane-associated lipoprotein involved in thiamine biosynthesis; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. (355 aa) |
| | AFG35195.1 | Putative membrane protein; PFAM: Rhomboid family. (233 aa) |
| | clpX | Endopeptidase Clp ATP-binding regulatory subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (410 aa) |
| | rpmF | PFAM: Ribosomal L32p protein family; Belongs to the bacterial ribosomal protein bL32 family. (60 aa) |
| | AFG35148.1 | Putative GTPase; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (270 aa) |
| | metG | Protein containing C-terminal region/beta chain of methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (653 aa) |
| | lexA | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (198 aa) |
| | AFG35094.1 | Maltose-binding periplasmic protein; PFAM: Bacterial extracellular solute-binding protein. (395 aa) |
| | gltX-2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (456 aa) |
| | AFG35089.1 | Putative metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain protein; PFAM: DHHA1 domain; Threonyl and Alanyl tRNA synthetase second additional domain. (375 aa) |
| | hslV | ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (186 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (643 aa) |
| | AFG35054.1 | Membrane protein implicated in regulation of membrane protease activity; PFAM: NfeD-like. (161 aa) |
| | AFG35053.1 | Membrane protease subunit, stomatin/prohibitin; PFAM: SPFH domain / Band 7 family. (312 aa) |
| | AFG35051.1 | Leucyl aminopeptidase (aminopeptidase T); PFAM: Thermophilic metalloprotease (M29). (398 aa) |
| | AFG35039.1 | PFAM: Peptidase S26; Peptidase S24-like; Belongs to the peptidase S26 family. (300 aa) |
| | rplS | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa) |
| | rpsP | PFAM: Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (91 aa) |
| | rplY | Ribosomal protein L25, Ctc-form; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (219 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (177 aa) |
| | AFG34989.1 | Peptidase family protein; PFAM: M42 glutamyl aminopeptidase; manually curated. (332 aa) |
| | AFG34978.1 | Zn-dependent carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. (489 aa) |
| | AFG34939.1 | Putative RNA-binding protein, snRNP like protein; PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA). (564 aa) |
| | AFG34899.1 | PFAM: Aminopeptidase I zinc metalloprotease (M18). (447 aa) |
| | prfA-2 | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (349 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (867 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (349 aa) |
| | def | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (169 aa) |
| | AFG34820.1 | Putative membrane-associated Zn-dependent protease; PFAM: Peptidase family M50; PDZ domain (Also known as DHR or GLGF). (495 aa) |
| | lspA | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (154 aa) |
| | AFG34787.1 | Xaa-Pro aminopeptidase; PFAM: Metallopeptidase family M24; Creatinase/Prolidase N-terminal domain; Belongs to the peptidase M24B family. (364 aa) |
| | tsf | Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (197 aa) |
| | AFG34728.1 | DNA replication and repair protein RadC; PFAM: Protein of unknown function (DUF2466); Belongs to the UPF0758 family. (218 aa) |
| | AFG34722.1 | PFAM: CAAX amino terminal protease family. (391 aa) |
| | AFG34710.1 | Serine hydrolase (FSH1). (321 aa) |
| | AFG34708.1 | Hypothetical protein. (424 aa) |
| | AFG34651.1 | Putative metal-dependent enzyme; PFAM: Protein of unknown function (DUF1385). (305 aa) |
| | AFG34636.1 | Hypothetical protein. (241 aa) |
| | msrA | methionine-R-sulfoxide reductase/methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (286 aa) |
| | AFG34631.1 | NAD-dependent protein deacetylase, SIR2 family; PFAM: Sir2 family. (252 aa) |
| | AFG34616.1 | Chemotaxis protein histidine kinase-like protein; PFAM: CheW-like domain; P2 response regulator binding domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain. (681 aa) |
| | proS | prolyl-tRNA synthetase, family II; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and i [...] (572 aa) |
| | cysS | PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; Belongs to the class-I aminoacyl-tRNA synthetase family. (476 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (472 aa) |
| | AFG34564.1 | ATPase with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); UvrB/uvrC motif; Belongs to the ClpA/ClpB family. (828 aa) |
| | rpmE | LSU ribosomal protein L31P; Binds the 23S rRNA. (70 aa) |
| | ftsH | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (616 aa) |
| | AFG34516.1 | Hypothetical protein. (388 aa) |
| | rpsT | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. (96 aa) |
| | hflX | GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (423 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | AFG34468.1 | PFAM: Outer membrane protein (OmpH-like). (144 aa) |
| | pcm | protein-L-isoaspartate and D-aspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (198 aa) |
| | AFG34397.1 | Putative peptidase; PFAM: Phospholipase/Carboxylesterase. (247 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (153 aa) |
| | rpmI | PFAM: Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (67 aa) |
| | gatC | glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (94 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | leuS | PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; Belongs to the class-I aminoacyl-tRNA synthetase family. (818 aa) |
| | AFG34191.1 | PFAM: Elongation factor Tu domain 2; Elongation factor G C-terminus; Elongation factor Tu GTP binding domain; Elongation factor G, domain IV. (685 aa) |
| | rplT | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | lnt | Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (491 aa) |
| | rpsR | SSU ribosomal protein S18P; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (76 aa) |
| | rpsF | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. (129 aa) |
| | AFG34378.1 | ATPase with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); Belongs to the ClpA/ClpB family. (739 aa) |
| | lon | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (822 aa) |
| | argS | arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R). (542 aa) |
| | AFG34354.1 | PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain. (470 aa) |
| | AFG34343.1 | Putative Zn-dependent peptidase; PFAM: Peptidase M16 inactive domain; Insulinase (Peptidase family M16). (421 aa) |
| | rpsI | PFAM: Ribosomal protein S9/S16; Belongs to the universal ribosomal protein uS9 family. (132 aa) |
| | rplM | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa) |
| | AFG34255.1 | PFAM: Ribosomal L27 protein. (90 aa) |
| | rplU | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (105 aa) |
| | AFG34243.1 | PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold. (429 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (867 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (184 aa) |
