node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFG35120.1 | fhs | Ferpe_1011 | Ferpe_1358 | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.913 |
AFG35120.1 | folD | Ferpe_1011 | Ferpe_1760 | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.910 |
AFG35120.1 | glyA | Ferpe_1011 | Ferpe_0323 | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
AFG35720.1 | folD | Ferpe_1662 | Ferpe_1760 | PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.921 |
AFG35720.1 | glyA | Ferpe_1662 | Ferpe_0323 | PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
fhs | AFG35120.1 | Ferpe_1358 | Ferpe_1011 | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | 0.913 |
fhs | folD | Ferpe_1358 | Ferpe_1760 | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.994 |
fhs | glyA | Ferpe_1358 | Ferpe_0323 | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
folD | AFG35120.1 | Ferpe_1760 | Ferpe_1011 | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | 0.910 |
folD | AFG35720.1 | Ferpe_1760 | Ferpe_1662 | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.921 |
folD | fhs | Ferpe_1760 | Ferpe_1358 | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.994 |
folD | glyA | Ferpe_1760 | Ferpe_0323 | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
glyA | AFG35120.1 | Ferpe_0323 | Ferpe_1011 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PFAM: Formiminotransferase domain, N-terminal subdomain; Formiminotransferase domain. | 0.900 |
glyA | AFG35720.1 | Ferpe_0323 | Ferpe_1662 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
glyA | fhs | Ferpe_0323 | Ferpe_1358 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formyltetrahydrofolate synthetase; PFAM: Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.967 |
glyA | folD | Ferpe_0323 | Ferpe_1760 | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.976 |