(33 nodes) RHO GTPases Activate WASPs and WAVEs, and Actin, conserved site network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F6R0S4_CIOIN	Uncharacterized protein; Belongs to the actin family. (375 aa)
	LOC100179260	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
	LOC100176247	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (179 aa)
	LOC100185133	Uncharacterized protein. (1138 aa)
	F6Z4V3_CIOIN	Tyrosine-protein kinase. (440 aa)
	F6UY72_CIOIN	Uncharacterized protein. (777 aa)
	F6UT21_CIOIN	WD_REPEATS_REGION domain-containing protein. (260 aa)
	LOC100182145	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (366 aa)
	F7A8L8_CIOIN	Uncharacterized protein. (519 aa)
	LOC101242999	Uncharacterized protein. (463 aa)
	F6SZF9_CIOIN	Phorbol-ester/DAG-type domain-containing protein. (219 aa)
	F6Z8I7_CIOIN	Uncharacterized protein. (428 aa)
	F6QHA4_CIOIN	Uncharacterized protein. (92 aa)
	F6SCP4_CIOIN	Uncharacterized protein. (377 aa)
	LOC100185562	Actin, cytoplasmic-like; Belongs to the actin family. (380 aa)
	F6QBJ1_CIOIN	Uncharacterized protein. (378 aa)
	F6URK3_CIOIN	Uncharacterized protein. (441 aa)
	F6YC34_CIOIN	C2 domain-containing protein. (724 aa)
	LOC100181735	wiskott-Aldrich syndrome protein family member 3-like. (204 aa)
	F6X1Y5_CIOIN	Uncharacterized protein. (142 aa)
	H2XKR2_CIOIN	Uncharacterized protein. (99 aa)
	LOC100181200	Profilin; Belongs to the profilin family. (151 aa)
	H2XM43_CIOIN	SH3 domain-containing protein. (671 aa)
	H2XPL3_CIOIN	Uncharacterized protein. (434 aa)
	LOC100185040	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
	LOC100185305	Cofilin; Belongs to the actin-binding proteins ADF family. (166 aa)
	H2XW16_CIOIN	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (216 aa)
	ar20	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	H2XXK1_CIOIN	Uncharacterized protein. (88 aa)
	H2XY10_CIOIN	Adenylyl cyclase-associated protein; Belongs to the CAP family. (481 aa)
	H2XZL1_CIOIN	WD_REPEATS_REGION domain-containing protein. (117 aa)
	H2Y009_CIOIN	WH2 domain-containing protein. (472 aa)
	H2Y0Y4_CIOIN	Coronin; Belongs to the WD repeat coronin family. (210 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QBJ1_CIOIN	F6QHA4_CIOIN	ENSCINP00000018112	ENSCINP00000016912	Uncharacterized protein.	Uncharacterized protein.	0.499
F6QBJ1_CIOIN	F6UT21_CIOIN	ENSCINP00000018112	ENSCINP00000009202	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.464
F6QBJ1_CIOIN	F7A8L8_CIOIN	ENSCINP00000018112	ENSCINP00000009378	Uncharacterized protein.	Uncharacterized protein.	0.504
F6QBJ1_CIOIN	H2XKR2_CIOIN	ENSCINP00000018112	ENSCINP00000030244	Uncharacterized protein.	Uncharacterized protein.	0.485
F6QBJ1_CIOIN	H2XM43_CIOIN	ENSCINP00000018112	ENSCINP00000030725	Uncharacterized protein.	SH3 domain-containing protein.	0.479
F6QBJ1_CIOIN	H2XW16_CIOIN	ENSCINP00000018112	ENSCINP00000033850	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.631
F6QBJ1_CIOIN	H2XY10_CIOIN	ENSCINP00000018112	ENSCINP00000034544	Uncharacterized protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.504
F6QBJ1_CIOIN	H2XZL1_CIOIN	ENSCINP00000018112	ENSCINP00000035095	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.446
F6QBJ1_CIOIN	LOC100176247	ENSCINP00000018112	ENSCINP00000003763	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.551
F6QBJ1_CIOIN	LOC100179260	ENSCINP00000018112	ENSCINP00000002402	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.551
F6QBJ1_CIOIN	LOC100181200	ENSCINP00000018112	ENSCINP00000030713	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.521
F6QBJ1_CIOIN	LOC100182145	ENSCINP00000018112	ENSCINP00000009296	Uncharacterized protein.	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.578
F6QBJ1_CIOIN	LOC100185040	ENSCINP00000018112	ENSCINP00000032174	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.548
F6QBJ1_CIOIN	LOC101242999	ENSCINP00000018112	ENSCINP00000011855	Uncharacterized protein.	Uncharacterized protein.	0.514
F6QBJ1_CIOIN	ar20	ENSCINP00000018112	ENSCINP00000033932	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.549
F6QHA4_CIOIN	F6QBJ1_CIOIN	ENSCINP00000016912	ENSCINP00000018112	Uncharacterized protein.	Uncharacterized protein.	0.499
F6QHA4_CIOIN	F6R0S4_CIOIN	ENSCINP00000016912	ENSCINP00000001541	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.499
F6QHA4_CIOIN	F6SCP4_CIOIN	ENSCINP00000016912	ENSCINP00000017903	Uncharacterized protein.	Uncharacterized protein.	0.499
F6QHA4_CIOIN	F6SZF9_CIOIN	ENSCINP00000016912	ENSCINP00000014300	Uncharacterized protein.	Phorbol-ester/DAG-type domain-containing protein.	0.431
F6QHA4_CIOIN	F6URK3_CIOIN	ENSCINP00000016912	ENSCINP00000023520	Uncharacterized protein.	Uncharacterized protein.	0.718