(63 nodes) Mixed, incl. EF-hand, calcium binding motif, and Activation of NMDA receptors and postsynaptic events network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100184552	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	LOC100178840	Uncharacterized protein. (600 aa)
	F6W6I5_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (477 aa)
	LOC100185594	Spermatogenesis-associated protein 21-like. (402 aa)
	F6RYH5_CIOIN	Uncharacterized protein. (814 aa)
	F7B609_CIOIN	Uncharacterized protein. (412 aa)
	F6US09_CIOIN	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1114 aa)
	F6PLQ2_CIOIN	Uncharacterized protein; Belongs to the MAGUK family. (971 aa)
	LOC100176025	Calcium/calmodulin-dependent protein kinase type IV-like; Belongs to the protein kinase superfamily. (335 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (520 aa)
	F6WQG5_CIOIN	Uncharacterized protein. (83 aa)
	F6ZFJ9_CIOIN	Alpha-type protein kinase domain-containing protein. (678 aa)
	LOC100181538	Uncharacterized protein. (157 aa)
	F6SYJ4_CIOIN	Uncharacterized protein. (192 aa)
	LOC494376	Calmodulin-like. (170 aa)
	F6X3Y8_CIOIN	Uncharacterized protein. (150 aa)
	F6Z839_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (317 aa)
	F6W4K8_CIOIN	Uncharacterized protein. (835 aa)
	LOC100178818	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (102 aa)
	LOC100179311	MAGUK p55 subfamily member 6-like; Belongs to the MAGUK family. (498 aa)
	Cam	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	LOC100176875	Hippocalcin-like protein 4. (202 aa)
	F6R798_CIOIN	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (678 aa)
	LOC100184418	Uncharacterized protein. (95 aa)
	LOC100182979	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Belongs to the protein kinase superfamily. (420 aa)
	F6PIW1_CIOIN	Protein kinase domain-containing protein. (363 aa)
	F6YTC2_CIOIN	Uncharacterized protein. (180 aa)
	F6Y940_CIOIN	Serine/threonine-protein phosphatase. (241 aa)
	Kcnq4/5	Uncharacterized protein. (702 aa)
	cam-k	Calmodulin-dependent protein kinase homologue isoform X1; Belongs to the protein kinase superfamily. (324 aa)
	F6V6X8_CIOIN	Uncharacterized protein. (650 aa)
	F6V542_CIOIN	Uncharacterized protein. (159 aa)
	LOC100185292	Uncharacterized protein LOC100185292. (195 aa)
	LOC100184110	Hippocalcin-like protein 1. (194 aa)
	LOC100181213	Neuronal calcium sensor 1-like. (195 aa)
	F6PQ89_CIOIN	Uncharacterized protein. (150 aa)
	F6QUS4_CIOIN	Uncharacterized protein. (210 aa)
	F7BGN2_CIOIN	KA1 domain-containing protein. (251 aa)
	LOC100182633	Peptidylprolyl isomerase. (215 aa)
	LOC100176472	Uncharacterized protein. (192 aa)
	F6R0E7_CIOIN	Uncharacterized protein. (148 aa)
	H2XJZ0_CIOIN	Guanylate kinase-like domain-containing protein. (80 aa)
	H2XLW2_CIOIN	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (304 aa)
	LOC100175378	Peptidylprolyl isomerase. (142 aa)
	H2XMT6_CIOIN	Uncharacterized protein. (462 aa)
	H2XNX0_CIOIN	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1038 aa)
	H2XNX1_CIOIN	EF-hand domain-containing protein. (171 aa)
	H2XPT9_CIOIN	Peptidylprolyl isomerase. (113 aa)
	H2XPY9_CIOIN	Uncharacterized protein. (127 aa)
	LOC100178497	Uncharacterized protein LOC100178497. (260 aa)
	LOC100186011	Uncharacterized protein LOC100186011 isoform X1. (163 aa)
	H2XRM4_CIOIN	Asp_Arg_Hydrox domain-containing protein. (107 aa)
	H2XSF3_CIOIN	Uncharacterized protein. (5075 aa)
	H2XUD7_CIOIN	Uncharacterized protein. (223 aa)
	H2XV34_CIOIN	Uncharacterized protein. (117 aa)
	H2XW06_CIOIN	Uncharacterized protein. (135 aa)
	LOC100175927	Death-associated protein kinase 2-like isoform X1. (526 aa)
	H2XYM2_CIOIN	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (193 aa)
	LOC100187330	Calcineurin subunit B type 1. (170 aa)
	H2Y004_CIOIN	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (232 aa)
	H2Y1G2_CIOIN	Uncharacterized protein. (310 aa)
	LOC100178190	Calcineurin B homologous protein 1-like. (189 aa)
	LOC100176168	Peptidylprolyl isomerase. (220 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	F6PIW1_CIOIN	ENSCINP00000017572	ENSCINP00000020206	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Protein kinase domain-containing protein.	0.616
Cam	F6PLQ2_CIOIN	ENSCINP00000017572	ENSCINP00000009884	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein; Belongs to the MAGUK family.	0.441
Cam	F6US09_CIOIN	ENSCINP00000017572	ENSCINP00000009229	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.449
Cam	F6W6I5_CIOIN	ENSCINP00000017572	ENSCINP00000004087	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.717
Cam	F6Y940_CIOIN	ENSCINP00000017572	ENSCINP00000021645	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Serine/threonine-protein phosphatase.	0.492
Cam	F6ZFJ9_CIOIN	ENSCINP00000017572	ENSCINP00000012557	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Alpha-type protein kinase domain-containing protein.	0.516
Cam	H2XJZ0_CIOIN	ENSCINP00000017572	ENSCINP00000029972	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Guanylate kinase-like domain-containing protein.	0.643
Cam	H2XNX0_CIOIN	ENSCINP00000017572	ENSCINP00000031353	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.487
Cam	H2XPT9_CIOIN	ENSCINP00000017572	ENSCINP00000031673	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Peptidylprolyl isomerase.	0.512
Cam	H2XSF3_CIOIN	ENSCINP00000017572	ENSCINP00000032587	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.565
Cam	H2XV34_CIOIN	ENSCINP00000017572	ENSCINP00000033518	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.492
Cam	Kcnq4/5	ENSCINP00000017572	ENSCINP00000021750	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.611
Cam	LOC100175927	ENSCINP00000017572	ENSCINP00000034118	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Death-associated protein kinase 2-like isoform X1.	0.574
Cam	LOC100176025	ENSCINP00000017572	ENSCINP00000010112	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calcium/calmodulin-dependent protein kinase type IV-like; Belongs to the protein kinase superfamily.	0.534
Cam	LOC100176168	ENSCINP00000017572	ENSCINP00000036043	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Peptidylprolyl isomerase.	0.512
Cam	LOC100182979	ENSCINP00000017572	ENSCINP00000019808	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Belongs to the protein kinase superfamily.	0.512
Cam	LOC100184418	ENSCINP00000017572	ENSCINP00000019667	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.445
Cam	cam-k	ENSCINP00000017572	ENSCINP00000023118	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calmodulin-dependent protein kinase homologue isoform X1; Belongs to the protein kinase superfamily.	0.693
Cam	kcnq1	ENSCINP00000017572	ENSCINP00000011044	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein; Belongs to the potassium channel family.	0.732
F6PIW1_CIOIN	Cam	ENSCINP00000020206	ENSCINP00000017572	Protein kinase domain-containing protein.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.616