(37 nodes) Mixed, incl. MAP kinase activation, and RAF-independent MAPK1/3 activation network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177240	Alpha-crystallin A chain-like; Belongs to the small heat shock protein (HSP20) family. (190 aa)
	erk3/4	Protein kinase domain-containing protein. (906 aa)
	F6TI28_CIOIN	Mitogen-activated protein kinase. (364 aa)
	elk	Transcription factor protein. (946 aa)
	mapkk3/6	Protein kinase domain-containing protein. (348 aa)
	atf3	Transcription factor protein isoform X1. (273 aa)
	Mapkk7	Protein kinase domain-containing protein. (478 aa)
	dusp8.16	Dual specificity phosphatase isoform X1. (750 aa)
	F6Y6H6_CIOIN	BZIP domain-containing protein. (449 aa)
	LOC100182088	Probable rhodanese domain-containing dual specificity protein phosphatase isoform X1. (373 aa)
	Ptp	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (987 aa)
	creb/atf-c	Transcription factor Ci-CREB/ATF-c isoform X1. (298 aa)
	F6U3T3_CIOIN	Ribosomal protein S6 kinase. (730 aa)
	F6WQ08_CIOIN	Protein kinase domain-containing protein. (473 aa)
	atf2/7	Transcription factor protein. (631 aa)
	nfkbp105	Uncharacterized protein. (1202 aa)
	erk1/2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (350 aa)
	Mapkk4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (475 aa)
	ets	Ets protein isoform X1. (659 aa)
	LOC100178703	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	jun	Transcription factor protein. (381 aa)
	Jnk	Mitogen-activated protein kinase. (437 aa)
	F6U8Y8_CIOIN	Uncharacterized protein. (302 aa)
	Erk5	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (820 aa)
	F6W7Y4_CIOIN	Uncharacterized protein. (229 aa)
	Dusp1.2.4.5	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (434 aa)
	F6RBA3_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (207 aa)
	Ikappab	ANK_REP_REGION domain-containing protein. (371 aa)
	H2XJU0_CIOIN	Ribosomal protein S6 kinase. (813 aa)
	ets/pointed1	Ets transcription factor isoform X3. (690 aa)
	LOC100181215	Astrocytic phosphoprotein PEA-15-like. (143 aa)
	srf	Transcription factor protein. (335 aa)
	LOC100180686	C-Jun-amino-terminal kinase-interacting protein 1 isoform X2. (432 aa)
	rel1	Rel1 protein isoform X1. (706 aa)
	fos	Transcription factor protein. (501 aa)
	LOC100181818	Transforming protein p54/c-ets-1. (127 aa)
	H2XYL8_CIOIN	Uncharacterized protein. (162 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dusp1.2.4.5	Erk5	ENSCINP00000023607	ENSCINP00000019973	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.643
Dusp1.2.4.5	F6TI28_CIOIN	ENSCINP00000023607	ENSCINP00000002924	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.531
Dusp1.2.4.5	F6Y6H6_CIOIN	ENSCINP00000023607	ENSCINP00000007607	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	BZIP domain-containing protein.	0.478
Dusp1.2.4.5	Jnk	ENSCINP00000023607	ENSCINP00000018935	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.721
Dusp1.2.4.5	Mapkk7	ENSCINP00000023607	ENSCINP00000005970	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.685
Dusp1.2.4.5	erk1/2	ENSCINP00000023607	ENSCINP00000014552	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.643
Dusp1.2.4.5	erk3/4	ENSCINP00000023607	ENSCINP00000002522	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Protein kinase domain-containing protein.	0.499
Dusp1.2.4.5	ets	ENSCINP00000023607	ENSCINP00000015902	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Ets protein isoform X1.	0.405
Dusp1.2.4.5	ets/pointed1	ENSCINP00000023607	ENSCINP00000030013	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Ets transcription factor isoform X3.	0.471
Dusp1.2.4.5	jun	ENSCINP00000023607	ENSCINP00000018871	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor protein.	0.432
Dusp1.2.4.5	srf	ENSCINP00000023607	ENSCINP00000032435	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor protein.	0.517
Erk5	Dusp1.2.4.5	ENSCINP00000019973	ENSCINP00000023607	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.643
Erk5	F6RBA3_CIOIN	ENSCINP00000019973	ENSCINP00000023986	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.462
Erk5	F6U3T3_CIOIN	ENSCINP00000019973	ENSCINP00000011573	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Ribosomal protein S6 kinase.	0.711
Erk5	F6W7Y4_CIOIN	ENSCINP00000019973	ENSCINP00000021985	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.674
Erk5	F6WQ08_CIOIN	ENSCINP00000019973	ENSCINP00000011785	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein.	0.715
Erk5	F6Y6H6_CIOIN	ENSCINP00000019973	ENSCINP00000007607	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	BZIP domain-containing protein.	0.728
Erk5	H2XJU0_CIOIN	ENSCINP00000019973	ENSCINP00000029922	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Ribosomal protein S6 kinase.	0.658
Erk5	H2XYL8_CIOIN	ENSCINP00000019973	ENSCINP00000034752	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.462
Erk5	Jnk	ENSCINP00000019973	ENSCINP00000018935	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase.	0.407