(14 nodes) Mixed, incl. Activation of the AP-1 family of transcription factors, and MAP kinase activity network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177240	Alpha-crystallin A chain-like; Belongs to the small heat shock protein (HSP20) family. (190 aa)
	erk3/4	Protein kinase domain-containing protein. (906 aa)
	F6TI28_CIOIN	Mitogen-activated protein kinase. (364 aa)
	mapkk3/6	Protein kinase domain-containing protein. (348 aa)
	atf3	Transcription factor protein isoform X1. (273 aa)
	F6Y6H6_CIOIN	BZIP domain-containing protein. (449 aa)
	F6WQ08_CIOIN	Protein kinase domain-containing protein. (473 aa)
	atf2/7	Transcription factor protein. (631 aa)
	LOC100178703	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	jun	Transcription factor protein. (381 aa)
	Jnk	Mitogen-activated protein kinase. (437 aa)
	Erk5	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (820 aa)
	F6W7Y4_CIOIN	Uncharacterized protein. (229 aa)
	fos	Transcription factor protein. (501 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Erk5	F6W7Y4_CIOIN	ENSCINP00000019973	ENSCINP00000021985	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.674
Erk5	F6WQ08_CIOIN	ENSCINP00000019973	ENSCINP00000011785	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein.	0.715
Erk5	F6Y6H6_CIOIN	ENSCINP00000019973	ENSCINP00000007607	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	BZIP domain-containing protein.	0.728
Erk5	Jnk	ENSCINP00000019973	ENSCINP00000018935	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase.	0.407
Erk5	LOC100177240	ENSCINP00000019973	ENSCINP00000001149	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Alpha-crystallin A chain-like; Belongs to the small heat shock protein (HSP20) family.	0.433
Erk5	LOC100178703	ENSCINP00000019973	ENSCINP00000016755	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.894
Erk5	atf2/7	ENSCINP00000019973	ENSCINP00000013632	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Transcription factor protein.	0.869
Erk5	atf3	ENSCINP00000019973	ENSCINP00000005786	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Transcription factor protein isoform X1.	0.638
Erk5	fos	ENSCINP00000019973	ENSCINP00000034304	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Transcription factor protein.	0.638
Erk5	jun	ENSCINP00000019973	ENSCINP00000018871	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Transcription factor protein.	0.680
Erk5	mapkk3/6	ENSCINP00000019973	ENSCINP00000005492	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Protein kinase domain-containing protein.	0.888
F6TI28_CIOIN	F6W7Y4_CIOIN	ENSCINP00000002924	ENSCINP00000021985	Mitogen-activated protein kinase.	Uncharacterized protein.	0.531
F6TI28_CIOIN	F6WQ08_CIOIN	ENSCINP00000002924	ENSCINP00000011785	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.693
F6TI28_CIOIN	F6Y6H6_CIOIN	ENSCINP00000002924	ENSCINP00000007607	Mitogen-activated protein kinase.	BZIP domain-containing protein.	0.680
F6TI28_CIOIN	LOC100178703	ENSCINP00000002924	ENSCINP00000016755	Mitogen-activated protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838
F6TI28_CIOIN	atf2/7	ENSCINP00000002924	ENSCINP00000013632	Mitogen-activated protein kinase.	Transcription factor protein.	0.869
F6TI28_CIOIN	atf3	ENSCINP00000002924	ENSCINP00000005786	Mitogen-activated protein kinase.	Transcription factor protein isoform X1.	0.638
F6TI28_CIOIN	fos	ENSCINP00000002924	ENSCINP00000034304	Mitogen-activated protein kinase.	Transcription factor protein.	0.638
F6TI28_CIOIN	jun	ENSCINP00000002924	ENSCINP00000018871	Mitogen-activated protein kinase.	Transcription factor protein.	0.608
F6TI28_CIOIN	mapkk3/6	ENSCINP00000002924	ENSCINP00000005492	Mitogen-activated protein kinase.	Protein kinase domain-containing protein.	0.818