(35 nodes) BMP signaling pathway, and TGF-beta signaling pathway network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6TS32_CIOIN	c-SKI_SMAD_bind domain-containing protein. (624 aa)
	LOC100176536	Uncharacterized protein. (219 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
	tgfbr-iia	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa)
	noggin	Noggin protein precursor. (219 aa)
	nodal	Transforming growth factor beta superfamily signaling ligand isoform X1. (415 aa)
	tgfbr-ia	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (423 aa)
	tgfbr-ic	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	F7BJ70_CIOIN	Uncharacterized protein. (200 aa)
	bmp5/7-like	Transforming growth factor beta superfamily signaling ligand isoform X1. (660 aa)
	F6QML6_CIOIN	Protein kinase domain-containing protein. (211 aa)
	F7B9G3_CIOIN	TGF_BETA_2 domain-containing protein. (387 aa)
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	tgfbr-ib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
	Smad1/5	MH2 domain-containing protein. (344 aa)
	F6T2W0_CIOIN	Uncharacterized protein. (388 aa)
	F6SGS4_CIOIN	Uncharacterized protein. (229 aa)
	LOC100178575	Mothers against decapentaplegic homolog. (426 aa)
	F6UCG6_CIOIN	FYVE-type domain-containing protein. (742 aa)
	F6W446_CIOIN	E3 ubiquitin-protein ligase. (752 aa)
	tgfbeta-na2	Transforming growth factor beta superfamily signaling ligand precursor. (443 aa)
	Lefty/antivin	TGF_BETA_2 domain-containing protein. (385 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	smad6/7	Mothers against decapentaplegic homolog. (361 aa)
	tgfbeta-na4	TGF_BETA_2 domain-containing protein. (442 aa)
	Tgfbeta-na1	TGF_BETA_2 domain-containing protein. (492 aa)
	LOC100186391	Uncharacterized protein LOC100186391. (466 aa)
	F6Y6R0_CIOIN	Uncharacterized protein. (393 aa)
	LOC778850	Zinc finger protein. (676 aa)
	dan	DAN protein. (266 aa)
	H2XKU2_CIOIN	MH1 domain-containing protein. (145 aa)
	Bmp2/4	TGFb_propeptide domain-containing protein. (376 aa)
	H2XX81_CIOIN	Ig-like domain-containing protein. (251 aa)
	H2Y0M3_CIOIN	CHRD domain-containing protein. (251 aa)
	smad2/3a	Mothers against decapentaplegic homolog. (446 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp2/4	F6SGS4_CIOIN	ENSCINP00000031019	ENSCINP00000012417	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.543
Bmp2/4	F6T2W0_CIOIN	ENSCINP00000031019	ENSCINP00000012407	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.780
Bmp2/4	F6UCG6_CIOIN	ENSCINP00000031019	ENSCINP00000012970	TGFb_propeptide domain-containing protein.	FYVE-type domain-containing protein.	0.652
Bmp2/4	F6W446_CIOIN	ENSCINP00000031019	ENSCINP00000016361	TGFb_propeptide domain-containing protein.	E3 ubiquitin-protein ligase.	0.640
Bmp2/4	F6Y6R0_CIOIN	ENSCINP00000031019	ENSCINP00000026794	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.418
Bmp2/4	F7BJ70_CIOIN	ENSCINP00000031019	ENSCINP00000005979	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.418
Bmp2/4	H2XKU2_CIOIN	ENSCINP00000031019	ENSCINP00000030274	TGFb_propeptide domain-containing protein.	MH1 domain-containing protein.	0.622
Bmp2/4	H2Y0M3_CIOIN	ENSCINP00000031019	ENSCINP00000035457	TGFb_propeptide domain-containing protein.	CHRD domain-containing protein.	0.543
Bmp2/4	LOC100176536	ENSCINP00000031019	ENSCINP00000000344	TGFb_propeptide domain-containing protein.	Uncharacterized protein.	0.542
Bmp2/4	LOC100178575	ENSCINP00000031019	ENSCINP00000012794	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.507
Bmp2/4	LOC778850	ENSCINP00000031019	ENSCINP00000027627	TGFb_propeptide domain-containing protein.	Zinc finger protein.	0.586
Bmp2/4	Smad1/5	ENSCINP00000031019	ENSCINP00000012287	TGFb_propeptide domain-containing protein.	MH2 domain-containing protein.	0.743
Bmp2/4	Tgfbeta-na1	ENSCINP00000031019	ENSCINP00000024911	TGFb_propeptide domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.579
Bmp2/4	Tgfbr-iib	ENSCINP00000031019	ENSCINP00000000345	TGFb_propeptide domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.448
Bmp2/4	bmp5/7-like	ENSCINP00000031019	ENSCINP00000007797	TGFb_propeptide domain-containing protein.	Transforming growth factor beta superfamily signaling ligand isoform X1.	0.799
Bmp2/4	noggin	ENSCINP00000031019	ENSCINP00000002170	TGFb_propeptide domain-containing protein.	Noggin protein precursor.	0.724
Bmp2/4	smad2/3a	ENSCINP00000031019	ENSCINP00000036287	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.507
Bmp2/4	smad4	ENSCINP00000031019	ENSCINP00000011529	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.906
Bmp2/4	smad6/7	ENSCINP00000031019	ENSCINP00000018319	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.827
Bmp2/4	tgfbr-ia	ENSCINP00000031019	ENSCINP00000003351	TGFb_propeptide domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.869