(31 nodes) Mixed, incl. CREB1 phosphorylation through the activation of Adenylate Cyclase, and cGMP effects network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6SE21_CIOIN	Uncharacterized protein. (611 aa)
	LOC100176540	Uncharacterized protein LOC100176540. (333 aa)
	F6QI54_CIOIN	Uncharacterized protein. (1118 aa)
	LOC100179599	Uncharacterized protein. (381 aa)
	F6Y8P2_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (179 aa)
	LOC100184124	cGMP-dependent protein kinase. (662 aa)
	F7AQT2_CIOIN	Uncharacterized protein. (312 aa)
	F7A4Y2_CIOIN	Uncharacterized protein. (591 aa)
	LOC100176009	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (367 aa)
	F6U068_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (119 aa)
	LOC100179564	cAMP-dependent protein kinase type II regulatory subunit-like isoform X1. (394 aa)
	F7AP89_CIOIN	Phosphodiesterase. (630 aa)
	LOC100186854	THAP domain-containing protein 1-like. (260 aa)
	F6YN13_CIOIN	Phosphodiesterase. (807 aa)
	F6XG67_CIOIN	PDEase domain-containing protein. (156 aa)
	F6R5E2_CIOIN	Uncharacterized protein. (423 aa)
	LOC100180193	Uncharacterized protein LOC100180193 isoform X2. (585 aa)
	F7AX33_CIOIN	Tubby-like protein; Belongs to the TUB family. (446 aa)
	F6U5F8_CIOIN	Uncharacterized protein. (246 aa)
	F6V0V9_CIOIN	Tudor domain-containing protein. (223 aa)
	F6Q1C2_CIOIN	Uncharacterized protein. (297 aa)
	F7A8H3_CIOIN	cGMP-dependent protein kinase. (677 aa)
	H2XMX5_CIOIN	Cyclic nucleotide-binding domain-containing protein. (366 aa)
	H2XPT7_CIOIN	Uncharacterized protein. (105 aa)
	H2XQX1_CIOIN	Phosphodiesterase. (768 aa)
	H2XRM8_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (176 aa)
	H2XTZ7_CIOIN	Cyclic nucleotide-binding domain-containing protein. (193 aa)
	H2XVH9_CIOIN	Protein kinase domain-containing protein. (350 aa)
	H2XWX3_CIOIN	Guanylate cyclase domain-containing protein. (180 aa)
	H2XXD3_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. (314 aa)
	LOC100178228	ANF_receptor domain-containing protein. (426 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q1C2_CIOIN	F7AP89_CIOIN	ENSCINP00000025312	ENSCINP00000015277	Uncharacterized protein.	Phosphodiesterase.	0.479
F6R5E2_CIOIN	H2XXD3_CIOIN	ENSCINP00000020071	ENSCINP00000034317	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.521
F6R5E2_CIOIN	LOC100176009	ENSCINP00000020071	ENSCINP00000013406	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.521
F6R5E2_CIOIN	LOC100186854	ENSCINP00000020071	ENSCINP00000016478	Uncharacterized protein.	THAP domain-containing protein 1-like.	0.521
F6SE21_CIOIN	H2XXD3_CIOIN	ENSCINP00000000752	ENSCINP00000034317	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.543
F6SE21_CIOIN	LOC100176009	ENSCINP00000000752	ENSCINP00000013406	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.952
F6SE21_CIOIN	LOC100176540	ENSCINP00000000752	ENSCINP00000003614	Uncharacterized protein.	Uncharacterized protein LOC100176540.	0.900
F6SE21_CIOIN	LOC100186854	ENSCINP00000000752	ENSCINP00000016478	Uncharacterized protein.	THAP domain-containing protein 1-like.	0.524
F6U068_CIOIN	F6Y8P2_CIOIN	ENSCINP00000013646	ENSCINP00000007369	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.450
F6U068_CIOIN	F6YN13_CIOIN	ENSCINP00000013646	ENSCINP00000016568	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Phosphodiesterase.	0.529
F6U068_CIOIN	H2XQX1_CIOIN	ENSCINP00000013646	ENSCINP00000032055	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Phosphodiesterase.	0.429
F6U5F8_CIOIN	F7AX33_CIOIN	ENSCINP00000023290	ENSCINP00000021824	Uncharacterized protein.	Tubby-like protein; Belongs to the TUB family.	0.521
F6U5F8_CIOIN	H2XXD3_CIOIN	ENSCINP00000023290	ENSCINP00000034317	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.505
F6U5F8_CIOIN	LOC100176009	ENSCINP00000023290	ENSCINP00000013406	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.579
F6U5F8_CIOIN	LOC100179564	ENSCINP00000023290	ENSCINP00000014963	Uncharacterized protein.	cAMP-dependent protein kinase type II regulatory subunit-like isoform X1.	0.482
F6U5F8_CIOIN	LOC100179599	ENSCINP00000023290	ENSCINP00000005345	Uncharacterized protein.	Uncharacterized protein.	0.482
F6V0V9_CIOIN	F7AQT2_CIOIN	ENSCINP00000024931	ENSCINP00000010142	Tudor domain-containing protein.	Uncharacterized protein.	0.448
F6V0V9_CIOIN	H2XMX5_CIOIN	ENSCINP00000024931	ENSCINP00000031008	Tudor domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.448
F6V0V9_CIOIN	H2XPT7_CIOIN	ENSCINP00000024931	ENSCINP00000031671	Tudor domain-containing protein.	Uncharacterized protein.	0.448
F6V0V9_CIOIN	H2XTZ7_CIOIN	ENSCINP00000024931	ENSCINP00000033131	Tudor domain-containing protein.	Cyclic nucleotide-binding domain-containing protein.	0.448