STRINGSTRING
F6WHL2_CIOIN F6WHL2_CIOIN F6TSF1_CIOIN F6TSF1_CIOIN Zf(cchc/grf)-1 Zf(cchc/grf)-1 F6RJ65_CIOIN F6RJ65_CIOIN LOC108950147 LOC108950147 F6VD75_CIOIN F6VD75_CIOIN F6RZM2_CIOIN F6RZM2_CIOIN F6RZ99_CIOIN F6RZ99_CIOIN F6RYY5_CIOIN F6RYY5_CIOIN LOC100182084 LOC100182084 F6T6X1_CIOIN F6T6X1_CIOIN LOC100179894 LOC100179894 F6W2K0_CIOIN F6W2K0_CIOIN LOC100183184 LOC100183184 LOC100184693 LOC100184693 F6R4H7_CIOIN F6R4H7_CIOIN LOC100181411 LOC100181411 F6QHZ5_CIOIN F6QHZ5_CIOIN F6XMX2_CIOIN F6XMX2_CIOIN PIF1 PIF1 LOC100178968 LOC100178968 F6QXW9_CIOIN F6QXW9_CIOIN F6PPP3_CIOIN F6PPP3_CIOIN F6QIV0_CIOIN F6QIV0_CIOIN F6TBB0_CIOIN F6TBB0_CIOIN F7BA18_CIOIN F7BA18_CIOIN F6YH93_CIOIN F6YH93_CIOIN F6TV58_CIOIN F6TV58_CIOIN LOC100180409 LOC100180409 MCM7 MCM7 F7ATF3_CIOIN F7ATF3_CIOIN F6QND3_CIOIN F6QND3_CIOIN LOC100175771 LOC100175771 LOC100181422 LOC100181422 F6WMK2_CIOIN F6WMK2_CIOIN F6WMB2_CIOIN F6WMB2_CIOIN LOC100185652 LOC100185652 F6YH10_CIOIN F6YH10_CIOIN F6UIT3_CIOIN F6UIT3_CIOIN F7B4V9_CIOIN F7B4V9_CIOIN LOC100179869 LOC100179869 F7BF26_CIOIN F7BF26_CIOIN F6USX3_CIOIN F6USX3_CIOIN LOC100181635 LOC100181635 F6Y1Y0_CIOIN F6Y1Y0_CIOIN F6V4K8_CIOIN F6V4K8_CIOIN F6RKM9_CIOIN F6RKM9_CIOIN LOC100176054 LOC100176054 LOC100184859 LOC100184859 F6VN25_CIOIN F6VN25_CIOIN LOC100176493 LOC100176493 LOC100176589 LOC100176589 LOC100184902 LOC100184902 F6W6L5_CIOIN F6W6L5_CIOIN F6W685_CIOIN F6W685_CIOIN LOC100179759 LOC100179759 F6Z8G0_CIOIN F6Z8G0_CIOIN LOC100182716 LOC100182716 F6WCV2_CIOIN F6WCV2_CIOIN F6WC79_CIOIN F6WC79_CIOIN F6WBW9_CIOIN F6WBW9_CIOIN F6Q9T0_CIOIN F6Q9T0_CIOIN F6PLC9_CIOIN F6PLC9_CIOIN F6XHT6_CIOIN F6XHT6_CIOIN F6WUQ7_CIOIN F6WUQ7_CIOIN F6QH43_CIOIN F6QH43_CIOIN F7BPT5_CIOIN F7BPT5_CIOIN LOC100183401 LOC100183401 F7BEK1_CIOIN F7BEK1_CIOIN F7AWL5_CIOIN F7AWL5_CIOIN F6V6M0_CIOIN F6V6M0_CIOIN F6Q2W2_CIOIN F6Q2W2_CIOIN F6T368_CIOIN F6T368_CIOIN H2XJH5_CIOIN H2XJH5_CIOIN LOC113474468 LOC113474468 H2XJN2_CIOIN H2XJN2_CIOIN H2XKT2_CIOIN H2XKT2_CIOIN H2XL15_CIOIN H2XL15_CIOIN H2XL69_CIOIN H2XL69_CIOIN LOC100180075 LOC100180075 H2XN24_CIOIN H2XN24_CIOIN H2XN42_CIOIN H2XN42_CIOIN H2XNL8_CIOIN H2XNL8_CIOIN H2XNP0_CIOIN H2XNP0_CIOIN H2XNU2_CIOIN H2XNU2_CIOIN H2XNU4_CIOIN H2XNU4_CIOIN H2XPE3_CIOIN H2XPE3_CIOIN H2XR02_CIOIN H2XR02_CIOIN H2XRC3_CIOIN H2XRC3_CIOIN LOC104265697 LOC104265697 H2XRL5_CIOIN H2XRL5_CIOIN cdc45 cdc45 cbf-2 cbf-2 H2XT98_CIOIN H2XT98_CIOIN LOC100181925 LOC100181925 H2XUG9_CIOIN H2XUG9_CIOIN LOC100184078 LOC100184078 H2XV49_CIOIN H2XV49_CIOIN H2XWQ0_CIOIN H2XWQ0_CIOIN H2XWS4_CIOIN H2XWS4_CIOIN LOC100182514 LOC100182514 LOC100182896 LOC100182896 H2XZJ6_CIOIN H2XZJ6_CIOIN LOC100179616 LOC100179616 LOC100179093 LOC100179093 LOC100175682 LOC100175682 H2Y1I3_CIOIN H2Y1I3_CIOIN H2Y2T2_CIOIN H2Y2T2_CIOIN H2Y306_CIOIN H2Y306_CIOIN H2Y334_CIOIN H2Y334_CIOIN H2Y379_CIOIN H2Y379_CIOIN LOC100178294 LOC100178294
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F6WHL2_CIOINUmuC domain-containing protein. (288 aa)
F6TSF1_CIOINDNA_pol_B domain-containing protein. (217 aa)
Zf(cchc/grf)-1DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (456 aa)
F6RJ65_CIOINUncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
LOC108950147DNA helicase; Belongs to the MCM family. (798 aa)
F6VD75_CIOINUncharacterized protein. (553 aa)
F6RZM2_CIOINDNA polymerase. (382 aa)
F6RZ99_CIOINZinc-hook domain-containing protein. (477 aa)
F6RYY5_CIOINAAA_23 domain-containing protein. (400 aa)
LOC100182084Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (461 aa)
F6T6X1_CIOINTudor domain-containing protein. (431 aa)
LOC100179894Werner syndrome ATP-dependent helicase homolog isoform X1. (1194 aa)
F6W2K0_CIOINDUF1767 domain-containing protein. (486 aa)
LOC100183184Uncharacterized protein. (633 aa)
LOC100184693Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
F6R4H7_CIOINUncharacterized protein. (315 aa)
LOC100181411Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
F6QHZ5_CIOINFHA domain-containing protein. (234 aa)
F6XMX2_CIOINUncharacterized protein. (279 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (607 aa)
LOC100178968DNA polymerase. (1064 aa)
F6QXW9_CIOINHelicase ATP-binding domain-containing protein. (273 aa)
F6PPP3_CIOINAAA domain-containing protein. (738 aa)
F6QIV0_CIOINDNA_pol_E_B domain-containing protein. (328 aa)
F6TBB0_CIOINAAA_16 domain-containing protein. (432 aa)
F7BA18_CIOINDNA helicase; Belongs to the MCM family. (740 aa)
F6YH93_CIOINUncharacterized protein. (1111 aa)
F6TV58_CIOINUncharacterized protein. (147 aa)
LOC100180409Meiotic recombination protein SPO11. (385 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (726 aa)
F7ATF3_CIOINzf-4CXXC_R1 domain-containing protein. (286 aa)
F6QND3_CIOINMcm10 domain-containing protein. (755 aa)
LOC100175771Cell cycle checkpoint control protein; Belongs to the rad9 family. (424 aa)
LOC100181422Replication factor C subunit 2-like. (336 aa)
F6WMK2_CIOINMCM domain-containing protein; Belongs to the MCM family. (817 aa)
F6WMB2_CIOINUncharacterized protein. (524 aa)
LOC100185652Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (530 aa)
F6YH10_CIOINDNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (466 aa)
F6UIT3_CIOINUncharacterized protein. (162 aa)
F7B4V9_CIOINReplication factor C subunit 1. (866 aa)
LOC100179869Checkpoint protein; Belongs to the HUS1 family. (286 aa)
F7BF26_CIOINUncharacterized protein. (449 aa)
F6USX3_CIOINUncharacterized protein. (983 aa)
LOC100181635AAA domain-containing protein. (356 aa)
F6Y1Y0_CIOINUncharacterized protein. (217 aa)
F6V4K8_CIOINWD_REPEATS_REGION domain-containing protein. (965 aa)
F6RKM9_CIOINDNA helicase; Belongs to the MCM family. (820 aa)
LOC100176054DNA primase; Belongs to the eukaryotic-type primase small subunit family. (436 aa)
LOC100184859Replication factor C subunit 3-like. (355 aa)
F6VN25_CIOINUncharacterized protein. (889 aa)
LOC100176493AAA domain-containing protein. (844 aa)
LOC100176589DNA helicase; Belongs to the MCM family. (785 aa)
LOC100184902Geminin. (257 aa)
F6W6L5_CIOINMCM domain-containing protein; Belongs to the MCM family. (422 aa)
F6W685_CIOINUncharacterized protein. (428 aa)
LOC100179759DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (820 aa)
F6Z8G0_CIOINProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
LOC100182716Flap endonuclease GEN homolog 1. (709 aa)
F6WCV2_CIOINProtein kinase domain-containing protein. (510 aa)
F6WC79_CIOINUncharacterized protein. (347 aa)
F6WBW9_CIOINDNA_pol_E_B domain-containing protein. (165 aa)
F6Q9T0_CIOINUncharacterized protein. (231 aa)
F6PLC9_CIOINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (128 aa)
F6XHT6_CIOINUvrD-like helicase C-terminal domain-containing protein. (212 aa)
F6WUQ7_CIOINDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2157 aa)
F6QH43_CIOINRING-type domain-containing protein. (309 aa)
F7BPT5_CIOINCBFD_NFYB_HMF domain-containing protein. (75 aa)
LOC100183401Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (426 aa)
F7BEK1_CIOINDNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (219 aa)
F7AWL5_CIOINF-box domain-containing protein. (431 aa)
F6V6M0_CIOINUncharacterized protein. (701 aa)
F6Q2W2_CIOINANK_REP_REGION domain-containing protein. (223 aa)
F6T368_CIOINDNA_pol_B_exo1 domain-containing protein. (276 aa)
H2XJH5_CIOINANK_REP_REGION domain-containing protein. (95 aa)
LOC113474468Replication protein A 14 kDa subunit-like. (118 aa)
H2XJN2_CIOINRECA_2 domain-containing protein. (255 aa)
H2XKT2_CIOIN3'-5' exonuclease domain-containing protein. (128 aa)
H2XL15_CIOINSAE2 domain-containing protein. (153 aa)
H2XL69_CIOINUncharacterized protein. (458 aa)
LOC100180075DNA polymerase delta subunit 4-like isoform X1. (107 aa)
H2XN24_CIOINPI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (158 aa)
H2XN42_CIOINUncharacterized protein. (362 aa)
H2XNL8_CIOINOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (419 aa)
H2XNP0_CIOINUncharacterized protein. (243 aa)
H2XNU2_CIOINUncharacterized protein. (214 aa)
H2XNU4_CIOINUncharacterized protein. (530 aa)
H2XPE3_CIOINDNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
H2XR02_CIOINDUF1767 domain-containing protein. (229 aa)
H2XRC3_CIOINUncharacterized protein. (224 aa)
LOC104265697Chromosome transmission fidelity protein 8 homolog. (111 aa)
H2XRL5_CIOINzf-DNA_Pol domain-containing protein. (143 aa)
cdc45Uncharacterized protein. (249 aa)
cbf-2Transcription factor CBF/NF-Y/archaeal histone -2. (156 aa)
H2XT98_CIOINRECA_2 domain-containing protein. (265 aa)
LOC100181925DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
H2XUG9_CIOINHelicase ATP-binding domain-containing protein. (310 aa)
LOC100184078CDT1 domain-containing protein. (407 aa)
H2XV49_CIOINFAT domain-containing protein. (219 aa)
H2XWQ0_CIOINHELICc2 domain-containing protein. (349 aa)
H2XWS4_CIOINUncharacterized protein. (179 aa)
LOC100182514Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC100182896DNA replication complex GINS protein PSF1. (195 aa)
H2XZJ6_CIOINUncharacterized protein. (400 aa)
LOC100179616UmuC domain-containing protein. (440 aa)
LOC100179093AAA domain-containing protein. (329 aa)
LOC100175682DNA polymerase delta subunit 3. (469 aa)
H2Y1I3_CIOINUncharacterized protein. (231 aa)
H2Y2T2_CIOINFAT domain-containing protein. (235 aa)
H2Y306_CIOINSld5 domain-containing protein. (206 aa)
H2Y334_CIOINUncharacterized protein. (198 aa)
H2Y379_CIOINRPA_C domain-containing protein. (133 aa)
LOC100178294Uncharacterized protein. (765 aa)
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt
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