(15 nodes) Nonhomologous end joining complex, and APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway network (Ciona intestinalis)

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second shell of interactors

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Your Input:
	LOC100177452	Uncharacterized protein. (603 aa)
	zf(parp)-2	DNA ligase. (859 aa)
	LOC100185732	DRMBL domain-containing protein. (277 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	APTX	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...] (380 aa)
	F6UX10_CIOIN	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (655 aa)
	F6U857_CIOIN	Uncharacterized protein. (468 aa)
	F7A9P4_CIOIN	NUC194 domain-containing protein. (726 aa)
	F6RAS4_CIOIN	Uncharacterized protein. (405 aa)
	F6TYB0_CIOIN	BRCT domain-containing protein. (246 aa)
	H2XNN7_CIOIN	Uncharacterized protein. (112 aa)
	LOC100177850	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (326 aa)
	H2Y3C6_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (540 aa)
	H2Y3M4_CIOIN	Uncharacterized protein. (185 aa)
	LOC100183893	Uncharacterized protein. (480 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APTX	F6U857_CIOIN	ENSCINP00000017819	ENSCINP00000021753	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Uncharacterized protein.	0.642
APTX	F6UX10_CIOIN	ENSCINP00000017819	ENSCINP00000019410	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.677
APTX	LOC100177452	ENSCINP00000017819	ENSCINP00000001166	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Uncharacterized protein.	0.642
APTX	LOC100177850	ENSCINP00000017819	ENSCINP00000031514	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.517
APTX	LOC100183893	ENSCINP00000017819	ENSCINP00000036521	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Uncharacterized protein.	0.793
APTX	LOC100185732	ENSCINP00000017819	ENSCINP00000008060	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	DRMBL domain-containing protein.	0.506
APTX	zf(c2h2)-102	ENSCINP00000017819	ENSCINP00000009339	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.	0.610
APTX	zf(parp)-2	ENSCINP00000017819	ENSCINP00000005256	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	DNA ligase.	0.649
F6RAS4_CIOIN	F6TYB0_CIOIN	ENSCINP00000023998	ENSCINP00000027186	Uncharacterized protein.	BRCT domain-containing protein.	0.442
F6RAS4_CIOIN	F6UX10_CIOIN	ENSCINP00000023998	ENSCINP00000019410	Uncharacterized protein.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.883
F6RAS4_CIOIN	LOC100177452	ENSCINP00000023998	ENSCINP00000001166	Uncharacterized protein.	Uncharacterized protein.	0.825
F6RAS4_CIOIN	LOC100177850	ENSCINP00000023998	ENSCINP00000031514	Uncharacterized protein.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.442
F6RAS4_CIOIN	LOC100185732	ENSCINP00000023998	ENSCINP00000008060	Uncharacterized protein.	DRMBL domain-containing protein.	0.554
F6RAS4_CIOIN	zf(c2h2)-102	ENSCINP00000023998	ENSCINP00000009339	Uncharacterized protein.	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.	0.932
F6RAS4_CIOIN	zf(parp)-2	ENSCINP00000023998	ENSCINP00000005256	Uncharacterized protein.	DNA ligase.	0.634
F6TYB0_CIOIN	F6RAS4_CIOIN	ENSCINP00000027186	ENSCINP00000023998	BRCT domain-containing protein.	Uncharacterized protein.	0.442
F6TYB0_CIOIN	F6UX10_CIOIN	ENSCINP00000027186	ENSCINP00000019410	BRCT domain-containing protein.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.616
F6TYB0_CIOIN	F7A9P4_CIOIN	ENSCINP00000027186	ENSCINP00000023638	BRCT domain-containing protein.	NUC194 domain-containing protein.	0.656
F6TYB0_CIOIN	H2XNN7_CIOIN	ENSCINP00000027186	ENSCINP00000031270	BRCT domain-containing protein.	Uncharacterized protein.	0.487
F6TYB0_CIOIN	H2Y3M4_CIOIN	ENSCINP00000027186	ENSCINP00000036509	BRCT domain-containing protein.	Uncharacterized protein.	0.627